Drops of dew condensing on the leaves symbolizing condensates formed via phase separation in cells

Synthetic protein condensates for cellular and metabolic engineering

  • Zhi-Gang Qian
  • Sheng-Chen Huang
  • Xiao-Xia Xia
Review Article

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    • This perspective proposes general strategies for phase-separation-related biological studies, including proper experimental designs to validate and characterize phase-separation phenomena, connections to biological functions and some caveats to avoid common misunderstandings.

      • Yifei Gao
      • Xi Li
      • Yi Lin
      Perspective
    • Protein condensates are subcellular structures that enrich and confine molecules in cells. This Review details how condensates can be engineered with responsiveness and on-demand functions, thus pushing cellular and metabolic engineering to a new level.

      • Zhi-Gang Qian
      • Sheng-Chen Huang
      • Xiao-Xia Xia
      Review Article
    • This Review introduces molecular features of the phase-separating biomolecules and how they affect phase-separation behavior in a complex intracellular environment, highlighting a complex interplay between structure, sequence and environment in the phase-separation process.

      • José A. Villegas
      • Meta Heidenreich
      • Emmanuel D. Levy
      Review Article
    • Clustering and multimerization of cell surface proteins (CSPs) are essential for triggering downstream intracellular signaling events. Membrane-anchored liquid–liquid phase-separation systems have now been developed to manipulate the spatiotemporal distribution and activation of CSPs.

      • Zheng Wang
      • Hong Zhang
      News & Views
    • YcaO enzymes are able to catalyze a diverse set of reactions and have found industrial applications. New biochemical data provide the first direct evidence for the unified reaction mechanism proposed a decade ago and will inform future enzyme engineering efforts.

      • Jesko Koehnke
      News & Views

Chemical Biology of Microbiomes

Interspecies communication in complex microbiome environments occurs through the small molecules, peptides, and proteins produced by both the host and the microbial residents, as highlighted in this collection of recent articles from Nature Portfolio.
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