Cell tagging with light

Unbiased matchmaking

Integration of omic approaches for testing thousands of interactions in an unbiased way reveals important interactions that drive cellular uptake of nanoparticles.

  • Cecilia Ka Wing Chan
  • Sze Ho Gwyneth Lau
  • Chung Hang Jonathan Choi
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  • Abstract representation of a public transit system, symbolizing the pathways of cellular metabolism

    This themed issue presents a collection of Reviews, Perspectives and Articles that aims to showcase how chemical tools have strengthened the existing interplay between physiology, chemical biology and biochemistry – to reveal new insights into cellular regulation.

  • Microbe interacting with host cell

    Interspecies communication in complex microbiome environments occurs through the small molecules, peptides, and proteins produced by both the host and the microbial residents, as highlighted in a special issue.

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    • Elucidating the interactions between serum protein-bound nanoparticles and cell-surface receptors typically operates on a per protein–receptor interaction basis. Integration of omic approaches for testing thousands of interactions unbiasedly reveals important interactions that drive cellular uptake of nanoparticles.

      • Cecilia Ka Wing Chan
      • Sze Ho Gwyneth Lau
      • Chung Hang Jonathan Choi
      News & Views
    • Transposon-associated transposase B (TnpB) is the putative ancestor of Cas nucleases. A TnpB-based adenine base editor has now been developed that is small enough to be loaded into a single AAV vector without compromising editing activity.

      • Beomjong Song
      • Sangsu Bae
      News & Views
    • Emerging evidence shows that ubiquitination can occur on nonlysine residues and nonproteinaceous substrates. This perspective summarizes the recent discoveries in noncanonical ubiquitination and advocates the development of chemical biology tools for new substrate identification and mechanistic dissection.

      • Daniel R. Squair
      • Satpal Virdee
      Perspective
    • In the post-genomic era, many genes and regulatory elements remain uncharacterized, including riboswitches — RNA structures that control gene expression by directly binding metabolites. Here, a new type of metal-responsive riboswitch that senses sodium cations expands the bacterial Na+ metabolic repertoire.

      • Lauren Waters
      News & Views
    • Biomolecular condensates form and dissolve in response to a wide range of signals. A new study reports a solubility-based phosphoproteome-profiling approach, which uncovers the extensive role of phosphorylation in regulating protein partitioning into condensates across the human proteome.

      • Kamran Rizzolo
      • Diana M. Mitrea
      News & Views

Chemical Biology of Microbiomes

Interspecies communication in complex microbiome environments occurs through the small molecules, peptides, and proteins produced by both the host and the microbial residents, as highlighted in this collection of recent articles from Nature Portfolio.
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