A wrench in the motor

  • Patrick M. M. Shelton
  • Tarun M. Kapoor
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  • Microbe interacting with host cell

    Interspecies communication in complex microbiome environments occurs through the small molecules, peptides, and proteins produced by both the host and the microbial residents, as highlighted in special issue.

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    The 2021 Nobel Prize in Physiology or Medicine was awarded to David Julius and Ardem Patapoutian "for their discoveries of receptors for temperature and touch." Their research identified transient receptor potential (TRP) and PIEZO ion channels as the proteins that sense these ubiquitous stimuli. To celebrate the award Nature Portfolio presents a Collection including publications from the winners,

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    • Structural biology and resistance analyses reveal the binding mode and the basis for selective inhibition of the ATP synthase rotary motor protein by glycosylated macrolides.

      • Patrick M. M. Shelton
      • Tarun M. Kapoor
      News & Views
    • An autocatalytic peptide cyclase defines a new subclass of plant ribosomally synthesized and post-translationally modified peptides (RiPPs). This discovery explains the origins of a large family of cyclic peptides and inspires new tools for mining these RiPPs across the plant kingdom.

      • Yit-Heng Chooi
      News & Views
    • Chemoproteomics-enabled identification of the targets of a hydroxylated cholesterol metabolite, 20(S)-hydroxycholesterol, reveals it to be the first reported endogenous ligand of the sigma-2 receptor, a drug target for neurodegeneration and neuropathic pain.

      • Weizhi Yu
      • Jeremy M. Baskin
      News & Views
    • This Review surveys how resistance mutations to small molecules and recent mutagenesis technologies have driven biological discovery across diverse fields of inquiry.

      • Allyson M. Freedy
      • Brian B. Liau
      Review Article
    • Genetic code expansion is emerging as a promising strategy to precisely regulate protein expression. A new study engineered cells that enabled noncanonical-amino-acid-triggered insulin expression to rapidly regulate blood glucose levels in a diabetic mouse model.

      • Jicheng Yu
      • Yuqi Zhang
      • Zhen Gu
      News & Views
Chemical Biology of Microbiomes

Chemical Biology of Microbiomes

Interspecies communication in complex microbiome environments occurs through the small molecules, peptides, and proteins produced by both the host and the microbial residents, as highlighted in this collection of recent articles from Nature Portfolio.
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