The case of the missing allosteric ribozymes

Curiously, allosteric ribozymes formed by the merger of RNA enzyme and RNA switch components are largely absent in today’s biological systems.

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  • This Perspective summarizes the known types of ligand-controlled ribozymes and riboswitches and discusses the reasons why allosteric ribozymes formed by fusion of RNA enzymes and RNA aptamers are rare in today’s biological systems.

    • Shanker S. S. Panchapakesan
    • Ronald R. Breaker
  • The cryo-EM structures of Cas12g in complex with sgRNA in the absence and presence of target RNA reveal that the duplex formed by target RNA and crRNA binds to a central channel of Cas12g, inducing its conformational change and activation.

    • Zhuang Li
    • Heng Zhang
    • Leifu Chang
  • Crystal structures of a cobalamin-dependent radical S-adenosylmethionine (SAM) methylase reveal an unexpected mechanism that involves substrate-assisted catalysis whereby the carboxylate group of the co-substrate SAM serves as a general base.

    • Hayley L. Knox
    • Percival Yang-Ting Chen
    • Squire J. Booker
  • The cumbersome encoding of digital data to cellular DNA hinders the use of cells as living hard drives. A new approach transfers digital information directly into cellular DNA by converting electrical signals into stable and interpretable changes in the genomes of bacterial populations.

    • Santi Bhattarai-Kline
    • Sierra K. Lear
    • Seth L. Shipman
    News & Views
  • Yin Yang 1 (YY1) is a transcription factor involved in gene regulation. A recent study has revealed G-quadruplex structures as novel binding targets of YY1, and their interactions regulate DNA looping and gene expression.

    • Haizhou Zhao
    • Chun Kit Kwok
    News & Views
  • The plant cuticle has long been considered a barrier to volatile organic compound emission. New research reveals the paradoxical role of the cuticle as a barrier and facilitator of volatile emissions in hybrid petunia.

    • Samuel J. Livingston
    • A. Lacey Samuels
    News & Views
Focus on Lipids and Membranes

Focus on Lipids and Membranes

This themed issue combines Reviews and Perspectives as well as original research that highlight the evolution of the approaches and conceptual advances in the study of cellular membranes and their component parts, lipids and proteins.

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