The case of the missing allosteric ribozymes

Curiously, allosteric ribozymes formed by the merger of RNA enzyme and RNA switch components are largely absent in today’s biological systems.

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  • This Perspective summarizes the known types of ligand-controlled ribozymes and riboswitches and discusses the reasons why allosteric ribozymes formed by fusion of RNA enzymes and RNA aptamers are rare in today’s biological systems.

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    • Ronald R. Breaker
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