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Latest Research

  • Article |

    Rather than their expected role in self-immunity, kinases encoded in the biosynthetic gene clusters of nucleoside natural products catalyze the phosphorylation of an early intermediate, a modification that is later removed in a downstream step.

    • Matthew M. Draelos
    • , Anyarat Thanapipatsiri
    • , Hilda Sucipto
    •  & Kenichi Yokoyama
  • Perspective |

    The conformational cycle of a bacterial voltage-gated sodium channel as it transitions from resting to activated open to inactivated closed states can be constructed from various crystal structure snapshots.

    • William A. Catterall
    • , Goragot Wisedchaisri
    •  & Ning Zheng
  • Perspective |

    The difficulty of antibiotic discovery posed by the double-membrane cell envelope of Gram-negative bacteria and active drug efflux requires better understanding of bacterial permeability and compound accumulation, and more diverse chemical libraries.

    • Shibin Zhao
    • , Justyna W. Adamiak
    • , Vincent Bonifay
    • , Jitender Mehla
    • , Helen I. Zgurskaya
    •  & Derek S. Tan
  • Review Article |

    Ion channel structures reveal mechanisms of lipid action, including how channel gating is altered by direct binding of signaling lipids and those within the membrane itself, as well as mechanical and architectural effects of membrane lipids.

    • Mackenzie J. Thompson
    •  & John E. Baenziger
  • Perspective |

    The Hedgehog (Hh) receptor PTCH1 uses its transporter-like function to inhibit the GPCR SMO by limiting the pool of accessible membrane cholesterol. Cholesterol acts as a ligand for SMO to activate downstream signaling.

    • Arun Radhakrishnan
    • , Rajat Rohatgi
    •  & Christian Siebold

News & Comment

  • Editorial |

    This themed issue features a collection of articles that explore long-standing questions in the study of lipids and membranes.

  • News & Views |

    Insects have many ways of disabling plant chemical defenses during feeding. Plant phloem feeders use surplus ingested sugar to block the activation of glucosinolate toxins, providing a target for precise resistance breeding.

    • Niels Agerbirk
  • News & Views |

    Metabolic engineering offers the flexibility to meet market demand for bioactive natural products but can be hampered when a necessary protein or intermediate is toxic. In yeast, modifying the subcellular localization of biosynthetic enzymes can alleviate toxicity and increase production titer.

    • Yang Gu
    •  & Peng Xu


Nobel Prize in Chemistry 2020

Springer Nature/The Nobel Foundation/Imagesource

Nobel Prize in Chemistry 2020

The 2020 Nobel Prize in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer Doudna for their pioneering work in gene-editing.

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