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Latest Research

  • Article |

    The authors identified a pH-dependent protonated status in the miR-21 precursor, which leads to additional base pairing in its secondary structure, thus affecting Dicer processing and miR-21 maturation.

    • Jared T. Baisden
    • , Joshua A. Boyer
    • , Bo Zhao
    • , Scott M. Hammond
    •  & Qi Zhang
  • Article |

    The helical bundle structure of the CC1 domain of STIM1 of the store-activated calcium channel CRAC is crucial to maintaining the channel resting state, and helix–helix interactions can be manipulated to normalize a disease-linked STIM1 mutant.

    • Petr Rathner
    • , Marc Fahrner
    • , Linda Cerofolini
    • , Herwig Grabmayr
    • , Ferdinand Horvath
    • , Heinrich Krobath
    • , Agrim Gupta
    • , Enrico Ravera
    • , Marco Fragai
    • , Matthias Bechmann
    • , Thomas Renger
    • , Claudio Luchinat
    • , Christoph Romanin
    •  & Norbert Müller
  • Article |

    Structural and kinetic analyses of the transcriptional repressor SqrR in multiple states indicate that its persulfide selectivity is determined by structural frustration in the disulfide form, favoring formation of the tetrasulfide-bridged product.

    • Daiana A. Capdevila
    • , Brenna J. C. Walsh
    • , Yifan Zhang
    • , Christopher Dietrich
    • , Giovanni Gonzalez-Gutierrez
    •  & David P. Giedroc
  • Article |

    Screening for substrate preference of the SARS-CoV and SARS-CoV-2 main protease Mpro leads to the development of activity-based probes useful for structural analysis and for visualization of active Mpro in infected patient epithelial cells.

    • Wioletta Rut
    • , Katarzyna Groborz
    • , Linlin Zhang
    • , Xinyuanyuan Sun
    • , Mikolaj Zmudzinski
    • , Bartlomiej Pawlik
    • , Xinyu Wang
    • , Dirk Jochmans
    • , Johan Neyts
    • , Wojciech Młynarski
    • , Rolf Hilgenfeld
    •  & Marcin Drag
  • Article |

    A screening approach finds VH-domain antibodies that bind the SARS-CoV-2 Spike protein receptor-binding domain at its interface with host ACE2. Bi-paratopic and multivalent binders have high affinity and potency.

    • Colton J. Bracken
    • , Shion A. Lim
    • , Paige Solomon
    • , Nicholas J. Rettko
    • , Duy P. Nguyen
    • , Beth Shoshana Zha
    • , Kaitlin Schaefer
    • , James R. Byrnes
    • , Jie Zhou
    • , Irene Lui
    • , Jia Liu
    • , Katarina Pance
    • , Caleigh M. Azumaya
    • , Julian R. Braxton
    • , Axel F. Brilot
    • , Meghna Gupta
    • , Fei Li
    • , Kyle E. Lopez
    • , Arthur Melo
    • , Gregory E. Merz
    • , Frank Moss
    • , Joana Paulino
    • , Thomas H. Pospiech Jr.
    • , Sergei Pourmal
    • , Cristina Puchades
    • , Alexandrea N. Rizo
    • , Amber M. Smith
    • , Ming Sun
    • , Paul V. Thomas
    • , Feng Wang
    • , Zanlin Yu
    • , Daniel Asarnow
    • , Julian R. Braxton
    • , Melody G. Campbell
    • , Cynthia M. Chio
    • , Un Seng Chio
    • , Miles Sasha Dickinson
    • , Devan Diwanji
    • , Bryan Faust
    • , Meghna Gupta
    • , Nick Hoppe
    • , Mingliang Jin
    • , Fei Li
    • , Junrui Li
    • , Yanxin Liu
    • , Gregory E. Merz
    • , Henry C. Nguyen
    • , Joana Paulino
    • , Thomas H. Pospiech Jr.
    • , Sergei Pourmal
    • , Smriti Sangwan
    • , Raphael Trenker
    • , Donovan Trinidad
    • , Eric Tse
    • , Kaihua Zhang
    • , Fengbo Zhou
    • , Caleigh M. Azumaya
    • , Christian Billesboelle
    • , Alisa Bowen
    • , Melody G. Campbell
    • , Devan Diwanji
    • , Nick Hoppe
    • , Yen-Li Li
    • , Phuong Nguyen
    • , Carlos Nowotny
    • , Cristina Puchades
    • , Mali Safari
    • , Smriti Sangwan
    • , Kaitlin Schaefer
    • , Amber M. Smith
    • , Raphael Trenker
    • , Tsz Kin Martin Tsui
    • , Natalie Whitis
    • , Jianhua Zhao
    • , Daniel Asarnow
    • , Caleigh M. Azumaya
    • , Cynthia M. Chio
    • , Bryan Faust
    • , Meghna Gupta
    • , Kate Kim
    • , Michelle Moritz
    • , Tristan W. Owens
    • , Joana Paulino
    • , Jessica K. Peters
    • , Sergei Pourmal
    • , Kaitlin Schaefer
    • , Tsz Kin Martin Tsui
    • , Justin Biel
    • , Ishan Deshpande
    • , Nadia Herrera
    • , Huong T. Kratochvil
    • , Xi Liu
    • , Ursula Schulze-Gahmen
    • , Iris D. Young
    • , Jen Chen
    • , Amy Diallo
    • , Loan Doan
    • , Sebastian Flores
    • , Meghna Gupta
    • , Mingliang Jin
    • , Huong T. Kratochvil
    • , Victor L. Lam
    • , Yang Li
    • , Megan Lo
    • , Gregory E. Merz
    • , Joana Paulino
    • , Aye C. Thwin
    • , Erron W. Titus
    • , Zanlin Yu
    • , Fengbo Zhou
    • , Yang Zhang
    • , David Bulkley
    • , Arceli Joves
    • , Almarie Joves
    • , Liam McKay
    • , Mariano Tabios
    • , Eric Tse
    • , David A. Agard
    • , Yifan Cheng
    • , James S. Fraser
    • , Adam Frost
    • , Natalia Jura
    • , Tanja Kortemme
    • , Nevan J. Krogan
    • , Aashish Manglik
    • , Oren S. Rosenberg
    • , Daniel R. Southworth
    • , Robert M. Stroud
    • , Kliment A. Verba
    • , Xin X. Zhou
    • , Kevin K. Leung
    •  & James A. Wells

News & Comment

  • News & Views |

    Metabolic engineering offers the flexibility to meet market demand for bioactive natural products but can be hampered when a necessary protein or intermediate is toxic. In yeast, modifying the subcellular localization of biosynthetic enzymes can alleviate toxicity and increase production titer.

    • Yang Gu
    •  & Peng Xu
  • Editorial |

    Targeted protein degradation provides a powerful complement to small-molecule inhibition in modulating protein activity and allows access to otherwise intractable drug targets.

Focus

<i>Nature Chemical Biology</i> 15th anniversary

John Tolliday / Alamy Stock Photo; Cover Design: Erin Dewalt

Nature Chemical Biology 15th anniversary

The June 2020 issue of Nature Chemical Biology marks 15 years of publication for the chemical biology community.

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