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Latest Research

  • Article |

    Phenotypic screening identifies a small-molecule inhibitor of the C. elegans serine hydrolase FAAH-4 that promotes longevity and identifies the enzyme as the functional homolog of mammalian monoacylglycerol lipase (MAGL).

    • Alice L. Chen
    • , Kenneth M. Lum
    • , Pablo Lara-Gonzalez
    • , Daisuke Ogasawara
    • , Armand B Cognetta III
    • , Alan To
    • , William H. Parsons
    • , Gabriel M. Simon
    • , Arshad Desai
    • , Michael Petrascheck
    • , Liron Bar-Peled
    •  & Benjamin F. Cravatt
  • Article |

    An engineered biosensor, which optimizes metal-sensing and couples it to transcriptional amplification cascades that produce a fluorescent protein, was applied to build a sensitive and easy-to-use sensor for the toxic metals As3+ and Hg2+.

    • Xinyi Wan
    • , Francesca Volpetti
    • , Ekaterina Petrova
    • , Chris French
    • , Sebastian J. Maerkl
    •  & Baojun Wang
  • Article |

    Enzymes from two discrete biosynthetic gene clusters in the entomopathogenic bacterium Xenorhabdus szentirmaii cooperate to produce a diverse array of phenazine natural products, including phenazine–peptide and phenazine–polyketide derivatives.

    • Yi-Ming Shi
    • , Alexander O. Brachmann
    • , Margaretha A. Westphalen
    • , Nick Neubacher
    • , Nicholas J. Tobias
    •  & Helge B. Bode
  • Article |

    Neopinone isomerase catalyzes the isomerization of the opiate alkaloid neopinone to codeinone, driving the biosynthesis of codeine and morphine and preventing accumulation of their isomers neopine and neomorphine.

    • Mehran Dastmalchi
    • , Xue Chen
    • , Jillian M. Hagel
    • , Limei Chang
    • , Rongji Chen
    • , Sukanya Ramasamy
    • , Sam Yeaman
    •  & Peter J. Facchini
  • Article |

    Affinity-based selection in solution enables the identification of high-affinity ligands for disrupting the MDM2–p53 interaction and binding to the HIV capsid protein from libraries of both linear and cyclic peptides containing non-canonical amino acids.

    • Fayçal Touti
    • , Zachary P. Gates
    • , Anupam Bandyopdhyay
    • , Guillaume Lautrette
    •  & Bradley L. Pentelute

News & Comment

  • News & Views |

    The molybdenum cofactor (Moco) is a fragile prosthetic group essential for most organisms. Nematodes are now capable of extracting Moco from their bacterial diet to mediate detoxification of sulfite.

    • Ralf R. Mendel
    •  & Thomas W. Hercher
  • News & Views |

    The N6-methyladenosine modification next to the 5′ RNA cap has dynamic regulatory functions. Recent findings show that this modification regulates the splicing and translational activity of different classes of RNAs.

    • Richard A. Padgett
  • News & Views |

    Powerful combinatorial peptide library methods allow the discovery of peptide leads from diverse libraries. A new platform based on tandem mass spectrometry peptide sequencing coupled with high-performance size-exclusion chromatography enables identification of high-affinity peptidic ligands from focused libraries.

    • Kit S. Lam

Collection

Nobel Prize in Chemistry 2018

Springer Nature/The Nobel Foundation/Imagesource

Nature events Directory