A checkpoint for insulin secretion

Checkpoint kinase 2 controls insulin secretion and glucose homeostasis

  • Angie Chi Nok Chong
  • J. Jeya Vandana
  • Shuibing Chen


  • Drops of dew condensing on leaves

    This themed issue presents a collection of Reviews, Perspectives and Articles that aim to reveal the molecular and chemical principles underlying phase-separated condensate formation and promote the development and use of new tools for the study of phase separation biology.

Nature Chemical Biology is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

Our Open Access option complies with funder and institutional requirements.


  • Engineered living materials harness the computational power of biology to control interesting material properties. Here the authors leverage complex transcriptional regulation of bacterial extracellular electron transfer to control hydrogel cross-linking with Boolean logic.

    • Austin J. Graham
    • Gina Partipilo
    • Benjamin K. Keitz
  • Owens et al. reported PFI-7, a selective and potent antagonist of GID4 of the CTLH E3 ligase complex, which enables identification of human GID4 targets. This study provides valuable insights into GID4 functions and a powerful tool for advancing new targeted protein degradation strategies.

    • Dominic D. G. Owens
    • Matthew E. R. Maitland
    • Cheryl H. Arrowsmith
  • A newly developed maternally selective nanobody antagonist against the angiotensin II type I receptor stabilizes the receptor in a hybrid conformation and simultaneously binds with specific small-molecule antagonists.

    • Meredith A. Skiba
    • Sarah M. Sterling
    • Andrew C. Kruse
  • Biochemical pathways for aromatic amino acid synthesis are ancient and highly conserved. Directed evolution of the β-subunit of tryptophan synthase (TrpB)—a proficient biocatalyst that converts indole to l-tryptophan—enabled this enzyme to make l-tyrosines from phenols, a pathway not (yet) known in nature.

    • Patrick J. Almhjell
    • Kadina E. Johnston
    • Frances H. Arnold
    • Targeted protein degradation has emerged as a promising approach in drug discovery, harnessing a cell’s intrinsic machinery to eliminate disease-related proteins. Now, a study paves the way to translating this technology into potential anti-mycobacterial therapies, by exploiting the bacterial protein-degradation complex.

      • Delia Preti
      • Valentina Albanese
      • Peggy Carla Raffaella Marconi
      News & Views
    • Reliably identifying ubiquitin ligase interactors and substrates has been a persistent challenge in cellular biology. A breakthrough comes in the form of a potent, selective and cell-active chemical probe, shedding light on the intricate functions of a key regulatory enzyme.

      • Shaoshuai Xie
      • Gang Li
      News & Views
    • Natural ribozymes can cleave RNA and single-stranded DNA (ssDNA) by transesterification or a blend of hydrolytic and transesterification reactions. Now, ribozymes have been discovered that catalyze the hydrolytic cleavage of ssDNA. Similar ribozymes could potentially replace large, immunogenic, protein-based nucleases in gene therapies.

      • Madeleine B. King
      • Audrone Lapinaite
      News & Views
    • Ferroptosis, a cell death mechanism induced by lipid peroxidation, is pivotal in tumor suppression. A recent study shows that tumor repopulating cells evade ferroptosis and develop resistance to therapy via subverting a lipid metabolism enzyme.

      • Yuelong Yan
      • Boyi Gan
      News & Views
    • We present a discovery pipeline integrating chemical fragment screening and time-resolved, high-throughput small-angle X-ray scattering (TR-HT-SAXS). This approach identifies allosteric chemical leads targeting distinct allosteric states of the mitochondrial oxidoreductase apoptosis-inducing factor (AIF). By monitoring kinetic rates of allosteric transition with TR-HT-SAXS, we link fragment structure–activity relationships (SARs) to biomolecular conformation.

      Research Briefing

Chemical Biology of Microbiomes

Interspecies communication in complex microbiome environments occurs through the small molecules, peptides, and proteins produced by both the host and the microbial residents, as highlighted in this collection of recent articles from Nature Portfolio.


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