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Latest Research

  • Brief Communication |

    Engineering of toehold-gated guide RNA (thgRNA) by tethering toehold riboswitches to sgRNAs enables the activation of CRISPR–Cas9 genome editing or transcriptional regulation in response to complementary synthetic or endogenous cellular RNAs.

    • Ka-Hei Siu
    •  & Wilfred Chen
  • Article |

    Protease-cleavable orthogonal-coiled-coil-based (SPOC) systems, in which split viral proteases are activated by small molecules and cleave coiled-coil protease substrates, reprogram signaling with rapid kinetics in mammalian cells.

    • Tina Fink
    • , Jan Lonzarić
    • , Arne Praznik
    • , Tjaša Plaper
    • , Estera Merljak
    • , Katja Leben
    • , Nina Jerala
    • , Tina Lebar
    • , Žiga Strmšek
    • , Fabio Lapenta
    • , Mojca Benčina
    •  & Roman Jerala
  • Article |

    Structural and biochemical analysis of a UBE2A mutation linked to intellectual disability reveals that the Q93E mutant perturbs the E2 catalytic microenvironment essential for lysine deprotonation during the ubiquitin-transfer process.

    • Juliana Ferreira de Oliveira
    • , Paula Favoretti Vital do Prado
    • , Silvia Souza da Costa
    • , Mauricio Luis Sforça
    • , Camila Canateli
    • , Americo Tavares Ranzani
    • , Mariana Maschietto
    • , Paulo Sergio Lopes de Oliveira
    • , Paulo A. Otto
    • , Rachel E. Klevit
    • , Ana Cristina Victorino Krepischi
    • , Carla Rosenberg
    •  & Kleber Gomes Franchini
  • Article |

    ZCCHC4 was identified as a mammalian ribosome RNA (rRNA) N6-methyladenosine (m6A) writer protein that installs m6A 4220 in 28S rRNA. 28S rRNA methylation affects global translation and cell growth and contributes to tumorigenesis in cancer cells.

    • Honghui Ma
    • , Xiaoyun Wang
    • , Jiabin Cai
    • , Qing Dai
    • , S. Kundhavai Natchiar
    • , Ruitu Lv
    • , Kai Chen
    • , Zhike Lu
    • , Hao Chen
    • , Yujiang Geno Shi
    • , Fei Lan
    • , Jia Fan
    • , Bruno P. Klaholz
    • , Tao Pan
    • , Yang Shi
    •  & Chuan He
  • Article |

    A class of nepetalactol-related short-chain dehydrogenase/reductases (NEPS) captures a reactive enol intermediate produced by iridoid synthase for cyclization and subsequent oxidation into nepetalactones, the active ingredients in catnip.

    • Benjamin R. Lichman
    • , Mohamed O. Kamileen
    • , Gabriel R. Titchiner
    • , Gerhard Saalbach
    • , Clare E. M. Stevenson
    • , David M. Lawson
    •  & Sarah E. O’Connor
  • Article |

    HDAC6 modulates acetylation at multiple lysine residues in the N-terminal intrinsically disordered region of RNA helicase DDX3X to regulate liquid–liquid phase separation and stress granule maturation.

    • Makoto Saito
    • , Daniel Hess
    • , Jan Eglinger
    • , Anatol W. Fritsch
    • , Moritz Kreysing
    • , Brian T. Weinert
    • , Chunaram Choudhary
    •  & Patrick Matthias

News & Comment

  • News & Views |

    Characterization of a novel mutation in the E2 ubiquitin-conjugating enzyme UBE2A accounts for the decreased activity of the mutant enzyme that underlies disease and provides important insight into the catalytic mechanism of E2s.

    • Martina Foglizzo
    •  & Catherine L. Day
  • Editorial |

    Structural studies of GPCRs defining conformational states en route to activation and clarifying the mechanisms of activation, ligand bias, and signaling will be critical for discovering new drugs that target a range of diseases.

Collection

Nobel Prize in Chemistry 2018

Springer Nature/The Nobel Foundation/Imagesource

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