Latest Research

  • Article |

    Patterns formed by artificial out-of-equilibrium chemical oscillating networks (such as the Belousov–Zhabotinsky reaction) are difficult to control with any precision. Now, it has been shown that low-intensity audible sound can be used to generate spatiotemporal patterns with a programmable distribution of redox- and pH-responsive chemical systems and supramolecular assemblies in solution.

    • Ilha Hwang
    • , Rahul Dev Mukhopadhyay
    • , Prabhu Dhasaiyan
    • , Seoyeon Choi
    • , Soo-Young Kim
    • , Young Ho Ko
    • , Kangkyun Baek
    •  & Kimoon Kim
  • Article |

    Class II terpene cyclases convert simple linear substrates into complex polycyclic compounds, which typically requires multiple protein domains. Now, a single-domain class II cyclase, a cyanobacterial merosterolic acid synthase, has been identified and characterized. High-resolution X-ray crystal structures provide detailed insights into how a minimalistic enzyme accomplishes this complex cyclization process.

    • Philipp Moosmann
    • , Felix Ecker
    • , Stefan Leopold-Messer
    • , Jackson K. B. Cahn
    • , Cora L. Dieterich
    • , Michael Groll
    •  & Jörn Piel
  • Article |

    Artificial intrinsically disordered proteins (A-IDPs) have now been shown to form exclusionary, intracellular droplets that can be designed using simple principles that are based on the aromatic/aliphatic ratio and molecular weight. Droplets that sequester an enzyme and modulate enzyme efficiency on the basis of the molecular weight of the A-IDPs were also engineered using A-IDPs as a minimal condensate scaffold.

    • Michael Dzuricky
    • , Bradley A. Rogers
    • , Abdulla Shahid
    • , Paul S. Cremer
    •  & Ashutosh Chilkoti
  • Article |

    Reversible nanoscale knotting and unknotting of a molecular strand can be used to control the handedness of helical organizations at macroscopic length scales. Dopant knotted and unknotted strands induce supramolecular helical structures of opposite handedness in achiral liquid crystals, and the left- and right-handed forms can be switched in situ.

    • Nathalie Katsonis
    • , Federico Lancia
    • , David A. Leigh
    • , Lucian Pirvu
    • , Alexander Ryabchun
    •  & Fredrik Schaufelberger
  • Article |

    Three crystalline complexes comprising a linear [UN2] moiety that is isoelectronic to the ubiquitous uranyl cation [UO2]2+ have been prepared by reaction of UCl5 or UBr5 with liquid ammonia. Quantum chemical calculations showed that the bonding in the [UN2] moieties is best described with two U≡N triple bonds.

    • Stefan S. Rudel
    • , H. Lars Deubner
    • , Matthias Müller
    • , Antti J. Karttunen
    •  & Florian Kraus
  • Article |

    CD44 is a cell-surface adhesion receptor associated with many biological processes that rely on cellular plasticity. Now, CD44 has been shown to mediate endocytosis of iron-bound hyaluronates. Furthermore, iron catalyses the demethylation of repressive histone marks, thereby unlocking the expression of genes regulating cellular plasticity.

    • Sebastian Müller
    • , Fabien Sindikubwabo
    • , Tatiana Cañeque
    • , Anne Lafon
    • , Antoine Versini
    • , Bérangère Lombard
    • , Damarys Loew
    • , Ting-Di Wu
    • , Christophe Ginestier
    • , Emmanuelle Charafe-Jauffret
    • , Adeline Durand
    • , Céline Vallot
    • , Sylvain Baulande
    • , Nicolas Servant
    •  & Raphaël Rodriguez
  • Article |

    The biosynthesis of goadvionins—hybrid lipopeptide antibiotics—is not fully understood. An unusual acyltransferase, GdvG, has now been identified and shown to catalyse a condensation reaction between an acyl-carrier-protein-tethered very-long-chain fatty acid and an eight-residue ribosomally synthesized and post-translationally modified peptide. The position of functional groups in the very-long acyl chain have been determined by tandem mass spectrometry.

    • Ryosuke Kozakai
    • , Takuto Ono
    • , Shotaro Hoshino
    • , Hidenori Takahashi
    • , Yohei Katsuyama
    • , Yoshinori Sugai
    • , Taro Ozaki
    • , Kazuya Teramoto
    • , Kanae Teramoto
    • , Koichi Tanaka
    • , Ikuro Abe
    • , Shumpei Asamizu
    •  & Hiroyasu Onaka
  • Article |

    Using readily accessible tropones and γ-methylidene-δ-valerolactones, the divergent synthesis of three classes of challenging [5.5.0] or [4.4.1] bicyclic systems has been achieved—with high efficiency and stereoselectivity—through Pd-catalysed higher-order cycloaddition. Mechanistic studies and density functional theory calculations indicate that the divergent reactions arise from the different reactivity of two diastereomeric intermediates.

    • Li-Cheng Yang
    • , Ya-Nong Wang
    • , Ruoyang Liu
    • , Yixin Luo
    • , Xiao Qian Ng
    • , Binmiao Yang
    • , Zi-Qiang Rong
    • , Yu Lan
    • , Zhihui Shao
    •  & Yu Zhao
  • Article |

    Chemical reactions usually proceed through either a radical, concerted or ionic mechanism; transformations in which all three mechanisms occur are rare. Now, the mechanical dissociation of an N-heterocyclic carbene precursor has been shown to proceed with the rupture of a C–C bond through concomitant heterolytic, concerted and homolytic pathways.

    • Robert Nixon
    •  & Guillaume De Bo
  • Article |

    Photoinduced isomerization reactions, including ring-opening reactions, lie at the heart of many chemical processes in nature. The pathway and dynamics of the ring opening of a model heterocycle have now been investigated by femtosecond photoelectron spectroscopy combined with ab initio theory, enabling the visualization of rich dynamics in both the ground and excited electronic states.

    • Shashank Pathak
    • , Lea M. Ibele
    • , Rebecca Boll
    • , Carlo Callegari
    • , Alexander Demidovich
    • , Benjamin Erk
    • , Raimund Feifel
    • , Ruaridh Forbes
    • , Michele Di Fraia
    • , Luca Giannessi
    • , Christopher S. Hansen
    • , David M. P. Holland
    • , Rebecca A. Ingle
    • , Robert Mason
    • , Oksana Plekan
    • , Kevin C. Prince
    • , Arnaud Rouzée
    • , Richard J. Squibb
    • , Jan Tross
    • , Michael N. R. Ashfold
    • , Basile F. E. Curchod
    •  & Daniel Rolles
  • Article |

    Engineering reverse transcriptases for modified or unnatural nucleic acids is challenging, but now a versatile method has been developed that enables the discovery of efficient reverse transcriptases. The method works with a wide range of template structures, including xeno-nucleic acids and can also be used to produce high-fidelity reverse transcriptases for RNA.

    • Gillian Houlihan
    • , Sebastian Arangundy-Franklin
    • , Benjamin T. Porebski
    • , Nithya Subramanian
    • , Alexander I. Taylor
    •  & Philipp Holliger
  • Article |

    Visualization of endogenous G-quadruplexes (G4s) in living cells by fluorescence microscopy has been hampered by the high concentrations of G4-binding probes required, which can artificially induce additional G4 formation. Now, a G4-specific fluorescent probe (SiR-PyPDS) has been developed that enables single-molecule and real-time detection of individual G4 structures in living cells without perturbing G4 formation and dynamics.

    • Marco Di Antonio
    • , Aleks Ponjavic
    • , Antanas Radzevičius
    • , Rohan T. Ranasinghe
    • , Marco Catalano
    • , Xiaoyun Zhang
    • , Jiazhen Shen
    • , Lisa-Maria Needham
    • , Steven F. Lee
    • , David Klenerman
    •  & Shankar Balasubramanian
  • Article |

    Multivalent binding is a common strategy to enhance the interactions between weak binding partners. Now, following this principle, DNA origami scaffolds have been used to arrange DNA aptamers into specific geometries and to optimize linker spacings and flexibilities, which results in artificial binding sites with very high affinities for their corresponding ligands.

    • Ali Aghebat Rafat
    • , Sandra Sagredo
    • , Melissa Thalhammer
    •  & Friedrich C. Simmel
  • Article |

    Many bacterial pathogens release effector enzymes belonging to the large Fic family, which modify host targets with nucleotide monophosphates. Now, recombinantly produced Fic enzymes have been equipped with synthetic thiol-reactive nucleotide derivatives to make covalent binary probes. The reaction of modified Fic enzymes with their targets permits covalent substrate capture and the structural determination of low-affinity ternary enzyme–nucleotide–substrate complexes.

    • Burak Gulen
    • , Marie Rosselin
    • , Joel Fauser
    • , Michael F. Albers
    • , Christian Pett
    • , Christoph Krisp
    • , Vivian Pogenberg
    • , Hartmut Schlüter
    • , Christian Hedberg
    •  & Aymelt Itzen
  • Article |

    The invariable core of a type II polyketide synthase has been characterized using X-ray crystallography, simulations, mutagenesis experiments and functional assays. The characterization of the ternary acyl carrier protein complexes provides a mechanistic understanding of the reactivity and could inform future engineering of this complex biosynthetic machinery.

    • Alois Bräuer
    • , Qiuqin Zhou
    • , Gina L. C. Grammbitter
    • , Maximilian Schmalhofer
    • , Michael Rühl
    • , Ville R. I. Kaila
    • , Helge B. Bode
    •  & Michael Groll
  • Article |

    The strength of electrostatic interactions in semiconductors strongly affects their performance in optoelectronic devices. Now, doping two-dimensional naphthalene-based lead halide perovskites with tetrachloro-1,2-benzoquinone has been shown to introduce donor–acceptor interactions within the organic network, without disrupting the inorganic sublattice. This in turn altered the energy of the materials’ electron–hole electrostatic Coulomb interactions.

    • James V. Passarelli
    • , Catherine M. Mauck
    • , Samuel W. Winslow
    • , Collin F. Perkinson
    • , Jacob C. Bard
    • , Hiroaki Sai
    • , Kristopher W. Williams
    • , Ashwin Narayanan
    • , Daniel J. Fairfield
    • , Mark P. Hendricks
    • , William A. Tisdale
    •  & Samuel I. Stupp
  • Article |

    Molecular rotors have been engineered within the bicyclopentane–dicarboxylate struts of a metal–organic framework—the bicyclic unit is the rotator and the carboxylate groups serve as the stator. In a zinc-based metal–organic framework, the crossed conformation of the strut–metal nodes enables fast rotation of the bicyclic moiety, but in the corresponding zirconium metal–organic framework a change in the conformation results in much slower rotation.

    • Jacopo Perego
    • , Silvia Bracco
    • , Mattia Negroni
    • , Charl X. Bezuidenhout
    • , Giacomo Prando
    • , Pietro Carretta
    • , Angiolina Comotti
    •  & Piero Sozzani
  • Article |

    Access to both enantiomers of a chiral target compound typically relies on reversing the absolute configuration of the chiral component in the reaction system that is used to make them. A time-dependent enantiodivergent synthesis is reported in which the same enantiomer of a chiral catalyst can give both enantiomers of the product, depending on the reaction time.

    • Hang-Fei Tu
    • , Pusu Yang
    • , Zi-Hua Lin
    • , Chao Zheng
    •  & Shu-Li You
  • Article |

    A general method for the enantioselective hydrocyanation of alkenes has been a long-standing synthetic challenge. Now, using a dual electrocatalytic approach that combines two synergistic redox catalytic cycles, a wide variety of chiral nitriles can be synthesized from conjugated alkenes in high enantioselectivity.

    • Lu Song
    • , Niankai Fu
    • , Brian G. Ernst
    • , Wai Hang Lee
    • , Michael O. Frederick
    • , Robert A. DiStasio Jr.
    •  & Song Lin
  • Article |

    The reduction of N2 to NH3 is mediated in living systems by the enzyme nitrogenase and in the chemical industry by the Haber–Bosch process; both systems rely on iron-based catalysis. Now, a molecular tri(iron)bis(nitrido) complex, prepared by reduction of a bis(iron)bis(iodo) precursor under an N2 atmosphere, has been isolated and shown to promote the formation of NH3 from H2.

    • Matthias Reiners
    • , Dirk Baabe
    • , Katharina Münster
    • , Marc-Kevin Zaretzke
    • , Matthias Freytag
    • , Peter G. Jones
    • , Yannick Coppel
    • , Sébastien Bontemps
    • , Iker del Rosal
    • , Laurent Maron
    •  & Marc D. Walter
  • Article |

    The highly frustrated spin-1/2 kagome lattice antiferromagnet, predicted to exhibit unconventional magnetic behaviours, has remained difficult to synthesize without structural imperfections. Now, a d1-titanium fluoride kagome lattice antiferromagnet has been prepared in which there is only one crystallographically distinct Ti3+ site and one type of bridging fluoride, and it is shown to be a frustrated magnet with unusual magnetic properties.

    • Ningxin Jiang
    • , Arun Ramanathan
    • , John Bacsa
    •  & Henry S. La Pierre
  • Article |

    Despite numerous potential applications, the development of light-responsive solid materials based on molecular photoswitches is impeded by the low efficiency of photoisomerization in the solid environment. Now a robust, solid porous material made from tetraphenylmethane and a photoswitchable overcrowded alkene exhibits nearly quantitative photoisomerization in the bulk and in photomodulation of gas uptake.

    • Fabio Castiglioni
    • , Wojciech Danowski
    • , Jacopo Perego
    • , Franco King-Chi Leung
    • , Piero Sozzani
    • , Silvia Bracco
    • , Sander J. Wezenberg
    • , Angiolina Comotti
    •  & Ben L. Feringa
  • Article |

    In contrast to the variety of stable carbonyl complexes of group 7–12 metals, few are known for group 3–5 metals; among those, cations have only been identified in the gas phase or by matrix isolation. Now, several unusual niobium and tantalum carbonyl compounds have been prepared as bulk crystalline compounds, including heptacarbonyl salts and the neutral ditantalum dodecacarbonyl.

    • W. Unkrig
    • , M. Schmitt
    • , D. Kratzert
    • , D. Himmel
    •  & I. Krossing
  • Article |

    The synthesis of chiral amino alcohols from simple alcohol starting materials can be achieved through a catalytic, asymmetric radical relay. Multiple catalysts work in concert to harness a H-atom transfer mechanism to enable enantio- and regioselective C–H amination by transient N-centred radicals.

    • Kohki M. Nakafuku
    • , Zuxiao Zhang
    • , Ethan A. Wappes
    • , Leah M. Stateman
    • , Andrew D. Chen
    •  & David A. Nagib
  • Article |

    Conventionally, urea is synthesized via two consecutive processes, N2 + H2 → NH3 followed by NH3 + CO2. Now, an electrocatalyst consisting of PdCu alloy nanoparticles on TiO2 nanosheets has been shown to directly couple N2 and CO2 in H2O to produce urea under ambient conditions.

    • Chen Chen
    • , Xiaorong Zhu
    • , Xiaojian Wen
    • , Yangyang Zhou
    • , Ling Zhou
    • , Hao Li
    • , Li Tao
    • , Qiling Li
    • , Shiqian Du
    • , Tingting Liu
    • , Dafeng Yan
    • , Chao Xie
    • , Yuqin Zou
    • , Yanyong Wang
    • , Ru Chen
    • , Jia Huo
    • , Yafei Li
    • , Jun Cheng
    • , Hui Su
    • , Xu Zhao
    • , Weiren Cheng
    • , Qinghua Liu
    • , Hongzhen Lin
    • , Jun Luo
    • , Jun Chen
    • , Mingdong Dong
    • , Kai Cheng
    • , Conggang Li
    •  & Shuangyin Wang
  • Article |

    Single-atom catalysts maximize metal atom efficiency and exhibit properties that can be considerably different to their nanoparticle equivalent. Now a general host–guest strategy to make various single-atom catalysts on nitrogen-doped carbon has been developed; the iridium variant electrocatalyses the formic acid oxidation reaction with high mass activity and displays high tolerance to CO poisoning.

    • Zhi Li
    • , Yuanjun Chen
    • , Shufang Ji
    • , Yan Tang
    • , Wenxing Chen
    • , Ang Li
    • , Jie Zhao
    • , Yu Xiong
    • , Yuen Wu
    • , Yue Gong
    • , Tao Yao
    • , Wei Liu
    • , Lirong Zheng
    • , Juncai Dong
    • , Yu Wang
    • , Zhongbin Zhuang
    • , Wei Xing
    • , Chun-Ting He
    • , Chao Peng
    • , Weng-Chon Cheong
    • , Qiheng Li
    • , Maolin Zhang
    • , Zheng Chen
    • , Ninghua Fu
    • , Xin Gao
    • , Wei Zhu
    • , Jiawei Wan
    • , Jian Zhang
    • , Lin Gu
    • , Shiqiang Wei
    • , Peijun Hu
    • , Jun Luo
    • , Jun Li
    • , Chen Chen
    • , Qing Peng
    • , Xiangfeng Duan
    • , Yu Huang
    • , Xiao-Ming Chen
    • , Dingsheng Wang
    •  & Yadong Li
  • Article |

    Site-selective functionalization of nearly identical C–H bonds has been a long-standing challenge. Now, a regioselective C–H amination has been achieved by [CpxIr(iii)] catalysis, which senses subtle electronic differences of allylic C–H bonds induced by remote electron-withdrawing groups. A linear correlation between Δ1JCH and ΔΔG is found, leading to predictable regioselectivities.

    • Honghui Lei
    •  & Tomislav Rovis
  • Article |

    The mechanism of nucleation for α-synuclein (α-Syn) aggregation and amyloid formation in Parkinson’s disease is unclear. Now, α-Syn has been shown to undergo liquid–liquid phase separation and a liquid-to-solid-like transition leading to amyloid fibril formation. This raises the possibility that liquid–liquid phase separation is a key pathogenic mechanism behind α-Syn aggregation in Parkinson’s disease.

    • Soumik Ray
    • , Nitu Singh
    • , Rakesh Kumar
    • , Komal Patel
    • , Satyaprakash Pandey
    • , Debalina Datta
    • , Jaladhar Mahato
    • , Rajlaxmi Panigrahi
    • , Ambuja Navalkar
    • , Surabhi Mehra
    • , Laxmikant Gadhe
    • , Debdeep Chatterjee
    • , Ajay Singh Sawner
    • , Siddhartha Maiti
    • , Sandhya Bhatia
    • , Juan Atilio Gerez
    • , Arindam Chowdhury
    • , Ashutosh Kumar
    • , Ranjith Padinhateeri
    • , Roland Riek
    • , G. Krishnamoorthy
    •  & Samir K. Maji
  • Article |

    A ruthenium-catalysed multicomponent reaction provides rapid and tunable access to 1,3-dienyl-6-oxy polyketide motifs. An initial alkene–alkyne coupling produces unsymmetrical 3-boryl-1,4-dienes. Allylation of aldehydes and ketones with these products is highly diastereoselective and results in the formation of two carbon–carbon bonds, two stereodefined olefins and up to three contiguous sp3 stereocentres.

    • Barry M. Trost
    • , James J. Cregg
    • , Christoph Hohn
    • , Wen-Ju Bai
    • , Guoting Zhang
    •  & Jacob S. Tracy
  • Article |

    Despite the importance of C–H methylation in medicinal chemistry, the application to densely functionalized complex molecules remains a challenge. Now, a novel cobalt-catalysed method takes advantage of inherently present functional groups to guide the C–H activation and a boron-based methyl source enables the late stage C–H methylation of pharmaceutically relevant substrates.

    • Stig D. Friis
    • , Magnus J. Johansson
    •  & Lutz Ackermann
  • Article |

    Non-canonical amino acids (ncAAs) can be incorporated into proteins in cells using orthogonal aminaocyl–tRNA synthetase/tRNA pairs; the most widely adopted system is based on a pyrrolysyl–tRNA synthetase (PylRS)/tRNA pair. Now, three new PylRS/tRNA pairs have been developed that are mutually orthogonal and can be used together to site-specifically incorporate three distinct ncAAs into a single protein.

    • Daniel L. Dunkelmann
    • , Julian C. W. Willis
    • , Adam T. Beattie
    •  & Jason W. Chin
  • Article |

    Proteins that interact with histone post-translational modifications have now been identified using an approach based on split-intein mediated histone semisynthesis. Histone modifications and disease-relevant mutations were installed into native chromatin with an adjacent photocross-linker to enable in situ cross-linking. This strategy enabled the determination of chromatin-relevant interactomes and represents a powerful tool for exploring epigenetic regulation and dysregulation at the molecular level.

    • Antony J. Burton
    • , Michael Haugbro
    • , Leah A. Gates
    • , John D. Bagert
    • , C. David Allis
    •  & Tom W. Muir
  • Article |

    A naturally occurring stand-alone and intermolecular Diels–Alderase, MaDA, has been identified from Morus alba cell cultures. MaDA is a FAD-dependent enzyme, which catalyses the intermolecular [4+2] cycloaddition via a concerted but asynchronous pericyclic pathway between morachalcone A and a diene generated from moracin C. Characterization revealed that MaDA possesses good substrate promiscuity towards both dienes and dienophiles.

    • Lei Gao
    • , Cong Su
    • , Xiaoxia Du
    • , Ruishan Wang
    • , Shuming Chen
    • , Yu Zhou
    • , Chengwei Liu
    • , Xiaojing Liu
    • , Runze Tian
    • , Liyun Zhang
    • , Kebo Xie
    • , She Chen
    • , Qianqian Guo
    • , Lanping Guo
    • , Yoshio Hano
    • , Manabu Shimazaki
    • , Atsushi Minami
    • , Hideaki Oikawa
    • , Niu Huang
    • , K. N. Houk
    • , Luqi Huang
    • , Jungui Dai
    •  & Xiaoguang Lei
  • Article |

    Water plays an active role in modulating guest recognition by both artificial and biological hosts, but how this role can be controlled is unclear. Now, the de-wetting of the non-polar pockets of cavitands is shown to be affected by the orientation of methyl groups encircling the portal, which moderate the enthalpic and entropic contributions driving recognition.

    • J. Wesley Barnett
    • , Matthew R. Sullivan
    • , Joshua A. Long
    • , Du Tang
    • , Thong Nguyen
    • , Dor Ben-Amotz
    • , Bruce C. Gibb
    •  & Henry S. Ashbaugh
  • Article |

    Oxygen is a potent inhibitor of radical polymerization reactions, but the facultative bacterium Shewanella oneidensis has now been shown to facilitate aerobic radical polymerizations by first consuming dissolved oxygen and then directing extracellular electron flux to a metal catalyst. Aerobic polymerization activity is dependent on the S. oneidensis genotype and can be initiated using lyophilized or spent cells.

    • Gang Fan
    • , Austin J. Graham
    • , Jayaker Kolli
    • , Nathaniel A. Lynd
    •  & Benjamin K. Keitz
  • Article |

    Scattering experiments in which two beams nearly co-propagate allow broadly tunable collision energies and can enable cold collisions. Now, such experiments have been combined with the preparation of NO molecules using stimulated emission to generate highly vibrationally excited states for state-to-state scattering studies, testing the theoretical gold standard in a regime not found in nature.

    • Chandika Amarasinghe
    • , Hongwei Li
    • , Chatura A. Perera
    • , Matthieu Besemer
    • , Junxiang Zuo
    • , Changjian Xie
    • , Ad van der Avoird
    • , Gerrit C. Groenenboom
    • , Hua Guo
    • , Jacek Kłos
    •  & Arthur G. Suits
  • Article |

    Metallacycles formed from two large, under-coordinated actinide MIV cations and two rigid arene-bridged aryloxide ligands are capable of binding dinitrogen inside their cavity. These f-block complexes can catalyse the reduction and functionalization of dinitrogen as well as the catalytic conversion of molecular dinitrogen to a secondary silylamine.

    • Polly L. Arnold
    • , Tatsumi Ochiai
    • , Francis Y. T. Lam
    • , Rory P. Kelly
    • , Megan L. Seymour
    •  & Laurent Maron
  • Article |

    The distortion of an amide group away from a planar conformation typically enhances its reactivity and such activation is usually achieved through the chemical synthesis of twisted amides. Now, it has been shown that a non-covalent activation strategy leading to accelerated hydrolysis can be achieved by binding a reactive twisted amide conformer inside a molecular cage.

    • Hiroki Takezawa
    • , Kosuke Shitozawa
    •  & Makoto Fujita
  • Article |

    The photoinduced dimerization of a prochiral anthracenecarboxylic acid occurs in an enantioselective fashion when the molecules are adsorbed on helical metal nanostructures. This enantiopreference arises mostly from the helicity of the silver and copper substrates—prepared using shear forces during the deposition process—and may also be influenced by chiroplasmonic effects.

    • Xueqin Wei
    • , Junjun Liu
    • , Guang-Jie Xia
    • , Junhong Deng
    • , Peng Sun
    • , Jason J. Chruma
    • , Wanhua Wu
    • , Cheng Yang
    • , Yang-Gang Wang
    •  & Zhifeng Huang
  • Article |

    Compounds of main-group elements rarely undergo direct carbonylation reactions. Now, an electron-rich silylene intermediate has been shown to readily react with CO to form a silylene carbonyl complex that is stable at room temperature. This complex engages in CO substitution as well as oxidative addition reactions.

    • Chelladurai Ganesamoorthy
    • , Juliane Schoening
    • , Christoph Wölper
    • , Lijuan Song
    • , Peter R. Schreiner
    •  & Stephan Schulz
  • Article |

    Despite five decades of research, the alkaloid (+)-brevianamide A has remained an elusive target for chemical synthesis. Now, it has been shown that the total synthesis of (+)-brevianamide A can be achieved in seven steps and 7.2% overall yield to give 750 mg of the target compound.

    • Robert C. Godfrey
    • , Nicholas J. Green
    • , Gary S. Nichol
    •  & Andrew L. Lawrence
  • Article |

    Aβ42 oligomers are key toxic species associated with protein aggregation; however, the molecular pathways determining the dynamics of oligomer populations have remained unknown. Now, direct measurements of oligomer populations, coupled to theory and computer simulations, define and quantify the dynamics of Aβ42 oligomers formed during amyloid aggregation.

    • Thomas C. T. Michaels
    • , Andela Šarić
    • , Samo Curk
    • , Katja Bernfur
    • , Paolo Arosio
    • , Georg Meisl
    • , Alexander J. Dear
    • , Samuel I. A. Cohen
    • , Christopher M. Dobson
    • , Michele Vendruscolo
    • , Sara Linse
    •  & Tuomas P. J. Knowles
  • Article |

    Au/C single-site catalysts have been validated commercially for acetylene hydrochlorination, but they have previously been prepared using highly oxidizing acidic solvents or additional ligands. It has now been shown that they can be made by impregnation of a metal salt from an acetone solution—generating catalysts with comparable activity to those synthesized by the other methods.

    • Xi Sun
    • , Simon R. Dawson
    • , Tanja E. Parmentier
    • , Grazia Malta
    • , Thomas E. Davies
    • , Qian He
    • , Li Lu
    • , David J. Morgan
    • , Nicholas Carthey
    • , Peter Johnston
    • , Simon A. Kondrat
    • , Simon J. Freakley
    • , Christopher J. Kiely
    •  & Graham J. Hutchings