Recognizing that an analogy can be drawn between steric effects in drug discovery and asymmetric catalysis has led to a powerful technique that can explain and potentially predict the outcome of asymmetric reactions.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Achinstein, P. (ed.) Science Rules: A Historical Introduction to Scientific Methods (Johns Hopkins Univ. Press, 2004).
Harper, K. C., Bess, E. N. & Sigman, M. S. Nature Chem. 4, 366–374 (2012).
Hammett, L. P. Chem. Rev. 17, 125–136 (1935).
Winstein, S. & Holness, N. J. J. Am. Chem. Soc. 77, 5562–5578 (1955).
Bott, G., Field, L. D. & Sternhell, S. J. Am. Chem. Soc. 102, 5618–5626 (1980).
Taft, R. W. Jr J. Am. Chem. Soc. 74, 3120–3128 (1952).
Charton, M. J. Am. Chem. Soc. 97, 1552–1556 (1975).
Miller, J. J. & Sigman, M. S. Angew. Chem. Int. Ed. 47, 771–774 (2008).
Harper, K. C. & Sigman, M. S. Science 333, 1875–1878 (2011).
Hansch, C. & Leo, A. Exploring QSAR: Fundamentals and Applications in Chemistry and Biology (American Chemical Society, 1995).
Verloop, A. & Tipker, J. in QSAR in Drug Design and Toxicology (eds Hadzi. B. & Jerman-Blazic, B.) 97 (Elsevier, 1987).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Miller, S. Correlating sterics in catalysis. Nature Chem 4, 344–345 (2012). https://doi.org/10.1038/nchem.1339
Published:
Issue Date:
DOI: https://doi.org/10.1038/nchem.1339
