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Site-selective reactions

Remodelling by diversity and design

Bioactive molecules frequently contain several very similarly reactive functional groups and it can thus be difficult to cause one to react selectively. Now, two separate studies present complementary approaches to this desirable goal.

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Figure 1: Two complementary approaches to the design of site-selective reactions.

References

  1. Wilcock, B. C. et al. Nature Chem. 4, 996–1003 10.1038/nchem.1495(2012).

    Article  CAS  Google Scholar 

  2. Lichtor, P. A. & Miller, S. J. Nature Chem. 4, 990–995 10.1038/nchem.1469(2012).

    Article  CAS  Google Scholar 

  3. Liu, C. C. & Schultz, P. G. Annu. Rev. Biochem. 79, 413–444 (2010).

    Article  CAS  Google Scholar 

  4. Masamune, S., Choy, W., Petersen, J. S. & Sita, L. R. Angew. Chem. Int. Ed. Engl. 24, 1–30 (1985).

    Article  Google Scholar 

  5. Bastian, A. A., Marcozzi, A. & Herrmann, A. Nature Chem. 4, 789–793 (2012).

    Article  CAS  Google Scholar 

  6. Chen, M. S. & White, M. C. Science 327, 566–571 (2010).

    Article  CAS  Google Scholar 

  7. Van Tamelen, E. E. & Heys, J. R. J. Am. Chem. Soc. 97, 1252–1253 (1974).

    Article  Google Scholar 

  8. Park, H. G., Do, J. H. & Chang, H. N. Biotechnol. Bioprocess Eng. 8, 1–8 (2003).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Eric N. Jacobsen.

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Tadross, P., Jacobsen, E. Remodelling by diversity and design. Nature Chem 4, 963–965 (2012). https://doi.org/10.1038/nchem.1509

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