Artistic representation of an enzyme adopting a misfolded structure during the folding process.

Read our March issue

This month we have a Meeting Report from the LGBTQ+ STEM Day held last year, a Q+A with Matthew Horwitz of the Synthesis Workshop podcast, and an In Your Element article focussing on cucurbiturils.


  • A Nobel medal in the foreground with some beakers and flasks in the background.

    The 2022 Nobel Prize in Chemistry has been awarded to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless for the development of click chemistry and bioorthogonal chemistry. In recognition of this award, Nature Portfolio presents a collection of research, review and opinion articles that focus on the origins, the development and the future directions inspired by the topic.

  • Nature Synthesis is open for submissions of original research articles. The journal will publish research, reviews and opinion articles on chemical and materials synthesis as well as enabling technological innovations.

  • COVID-19 and impact on peer review

    The COVID-19 pandemic is causing significant disruption and we are very aware that many researchers will have difficulty in meeting the standard timelines for our peer-review process. Please let us know if you need additional time. Our systems will continue to remind you of the original deadlines but we will be highly flexible as required.

Nature Chemistry is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

Our Open Access option complies with funder and institutional requirements.


  • In contrast to phosphine and arsine oxides, stibine oxides have been challenging to isolate in monomeric forms as they tend to polymerize. Now, such a SbO moiety has been kinetically stabilized using sterically bulky protecting groups, and its reactivity found to be substantially different to that of its lighter pnictogen counterparts.

    • John S. Wenger
    • Monica Weng
    • Timothy C. Johnstone
    Article Open Access
  • Quasicrystals are intriguing structures that exhibit long-range positional correlations but no periodicity in real space. Now, T-shaped amphiphilic molecules featuring rigid cores have been found to self-assemble into a columnar liquid quasicrystal with dodecagonal symmetry. The honeycomb structure observed arises from a strictly quasiperiodic tessellation of square, triangular and trapezoidal tiles, rather than from random tiling.

    • Xiangbing Zeng
    • Benjamin Glettner
    • Carsten Tschierske
  • The structural analysis of small crystals has remained challenging. Now, the structure of a small organic molecule, rhodamine-6G, has been resolved from microcrystals using an X-ray free-electron laser and electron diffraction. The former showed better reliability for atomic coordinates, whereas the latter was more sensitive to charges; both techniques accurately determined the position of hydrogen atoms.

    • Kiyofumi Takaba
    • Saori Maki-Yonekura
    • Koji Yonekura
  • Crystals of hexachlorobenzene have now been shown to support the autonomous motion of water and particulate matter over their surface. Parallel microchannels present at the surface of the crystal gradually widen by sublimation, propelling droplets of condensed ambient water that can also transport microscopic amounts of material such as silver microparticles.

    • Patrick Commins
    • Marieh B. Al-Handawi
    • Panče Naumov
  • Stereogenic sp3-hybridized carbon centres are the principal building blocks of chiral organic molecules. Usually, these centres are configurationally fixed. Now, low-energy pericyclic rearrangements have been used to create rigid cage molecules with fluxional sp3-stereochemistry, influencing chiral information transfer. The sp3-carbon stereochemistry of the cages is inverted through strain-assisted Cope rearrangements.

    • Aisha N. Bismillah
    • Toby G. Johnson
    • Paul R. McGonigal
    Article Open Access
    • Charge-transfer emission of any type is extremely rare for coordination complexes of iron. Now, an Fe(iii) complex has been devised that shows two-colour luminescence arising from dual metal-to-ligand and ligand-to-metal charge-transfer emission.

      • Robert J. Ortiz
      • David E. Herbert
      News & Views
    • Serial rotation electron diffraction (SerialRED) enables rapid and reliable phase analysis and structure determination of complex polycrystalline materials that cannot be routinely characterized using X-ray diffraction. Five zeolite phases were identified in a single synthesis product by automated screening of hundreds of crystals, demonstrating the power of SerialRED for materials development.

      Research Briefing
    • Nanomachines are central to life and are becoming an important part of self-regulated nanotechnologies. Inspired by natural self-assembled nanosystems, it has been shown that artificial nanosystems can evolve and adopt regulatory functions upon fragmentation of their structures into multiple components that reassemble to form the same nanostructure.

      Research Briefing
    • The adiabatic approximation is often applied to describe the scattering of molecules or atoms from solid surfaces. Now, unusual energy loss has been observed during the scattering of hyperthermal hydrogen atoms from a single crystalline Ge(111) surface — suggesting the existence of a non-adiabatic mechanism involving electronic interband transitions in the Ge that are induced by the hydrogen atoms.

      • Hermann Nienhaus
      News & Views
    • Kemi Oloyede reflects on the importance of having LGBTQ+ STEM events, and their role in combatting inertia in the scientific community.

      • Kemi Oloyede
      Meeting Report
  • The time between accepting a position as an assistant professor and taking the role is exciting and unique. But how much work is required before you even start? Shira Joudan ponders which tasks are necessary and how many times one should interrupt a very well-deserved break.

    • Shira Joudan
  • Rahul Dev Mukhopadhyay and Kimoon Kim consider how cucurbiturils — pumpkin-shaped macrocycles — went from curiosities to compelling cavitands for a host of applications.

    • Rahul Dev Mukhopadhyay
    • Kimoon Kim
    In Your Element
  • Matthew Horwitz, creator of the Synthesis Workshop video podcast, talks to Nature Chemistry about using podcasting as a driver of professional-level education in the chemistry community.

    • Katherine Geogheghan
  • Winter brings a spike in mortality rates, but rather than simply having more parties to divert our attention, Bruce Gibb suggests that perhaps we should be looking to the misunderstood mushroom to give us a boost.

    • Bruce C. Gibb
  • Methane hydrate clogs pipelines, is difficult to extract profitably, and exists in quantities sufficient to screw up Earth’s climate. Brett Thornton and Christian Stranne consider this confounding cage compound.

    • Brett F. Thornton
    • Christian Stranne
    In Your Element
  • Amilra Prasanna (AP) de Silva talks to Nature Chemistry about his path in chemistry, from photochemistry to sodium sensors to logic gates, through connections between people and between two places that share more than it may seem, Sri Lanka and Northern Ireland.

    • Anne Pichon

Nature Careers