Artist’s impression of a conical intersection emerging from a single, laser-driven trapped io

Read our November issue

This month, a Thesis that wonders what personal qualities help chemists achieve success in the lab, the usual mix of Articles and News and Views, and an In Your Element Article on ferrocene.


  • A Nobel medal in the foreground with some beakers and flasks in the background.

    The 2023 Nobel Prize in Chemistry has been awarded to Moungi G. Bawendi, Louis E. Brus and Alexei I. Ekimov for the discovery and synthesis of quantum dots. In recognition of this award, Nature Portfolio presents a collection of research, review and opinion articles that highlight the development of quantum dots over the past three decades.

  • A lab with robotic arms carrying out experiments

    The combination of techniques such as machine learning, artificial intelligence, robotics and automation can be used to accelerate chemical and materials synthesis. This Focus issue showcases developments in the automation and digitalization of synthesis, as well as highlights the challenges to be overcome in this area.

  • A petrochemical refinery located at the edge of a body of water illuminates the surroundings with its many bright lights at night

    Nature Chemical Engineering is open for submissions. The journal will cover a broad range of systems and scales that significantly advance fundamental research, aid product and process development and explore new technological solutions, all in the context of core chemical engineering approaches. It will publish research, reviews and opinion articles.

Nature Chemistry is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

Our Open Access option complies with funder and institutional requirements.


  • Polymethine dyes are bright and red-shifted fluorophores that lack an intrinsic turn-on mechanism, which leads to non-specific staining when applied to biological samples. Now the fluorescence of polymethine dyes was masked through an intracellular cyclization strategy that gets reversed upon binding an intended macromolecular target, providing specificity for live-cell imaging.

    • Annabell Martin
    • Pablo Rivera-Fuentes
    ArticleOpen Access
  • Late-stage functionalization of complex drug molecules is challenging. To address this problem, a discovery platform based on geometric deep learning and high-throughput experimentation was developed. The computational model predicts binary reaction outcome, reaction yield and regioselectivity with low error margins, enabling the functionalization of complex molecules without de novo synthesis.

    • David F. Nippa
    • Kenneth Atz
    • Gisbert Schneider
    ArticleOpen Access
  • Long polyynes have fascinating properties but they are difficult to synthesize as a consequence of their high reactivity. Now, it has been shown that cobalt carbonyl complexes can be used as masked alkyne equivalents, enabling the preparation of stable polyyne polyrotaxanes with up to 34 contiguous triple bonds.

    • Connor W. Patrick
    • Yueze Gao
    • Harry L. Anderson
    ArticleOpen Access
  • The inherent rigidity of the azaarene ring structure has made it challenging to achieve remote stereocontrol through asymmetric catalysis on these substrates. Now, through a photoenzymatic process, an ene-reductase system facilitates the production of diverse azaarenes with distant γ-stereocentres, highlighting the potential of biocatalysts for stereoselectivity at remote sites.

    • Maolin Li
    • Wesley Harrison
    • Huimin Zhao
  • Asymmetric decarboxylation can transform abundant carboxylic acids into valuable chiral molecules but faces major limitations due to the challenging enantiocontrol of proton transfer. Now the use of Brønsted acid catalysis in conjunction with an anchoring group strategy has enabled the decarboxylative protonation of aminomalonic acids to access diverse amino acids.

    • Wei-Feng Zheng
    • Jingdan Chen
    • Zhongxing Huang
  • Alkene hydrofluoroalkylation offers a promising route to diverse fluoroalkylated compounds but current methods have limitations, such as needing expensive fluoroalkylating reagents. Now, leveraging iron photocatalysis and hydrogen-atom-transfer catalysis, a hydrofluoroalkylation method has been developed that utilizes feedstock chemicals such as trifluoroacetic acid as direct fluoroalkyl radical precursors, providing a redox-neutral, general protocol to introduce fluoroalkyl moieties.

    • Kang-Jie Bian
    • Yen-Chu Lu
    • Julian G. West
  • Didier Astruc surveys the numerous applications of ferrocene, from catalysis to materials and redox-related devices including biosensors and nanomedicine.

    • Didier Astruc
    In Your Element
  • Few explosives are better-known to non-chemists than trinitrotoluene (TNT). Thomas M. Klapötke reflects on the enduring appeal of TNT and whether its starring role as an explosive is nearing its end.

    • Thomas M. Klapötke
    In Your Element
  • Teaching the history of science along with the science itself can give students greater context about the topic they are learning and a wider perspective on how it has developed. Michelle Francl, who has wrestled with how much time to spend on teaching history in the chemistry classroom for years, considers how unconventional histories can shift the curriculum.

    • Michelle Francl
  • Clinton Veale and Fanie van Heerden discuss the story of natamycin. From its humble telluric origins in Pietermaritzburg, this unique antimicrobial agent has risen to become a mainstay of the food and beverages industry.

    • Clinton G. L. Veale
    • Fanie R. van Heerden
    In Your Element
  • There are lots of expectations for assistant professors, and many opportunities that are good for your career. Shira Joudan reflects on making a personalized reference document for how to decide which opportunities are best to pursue, and to which to say ‘no’.

    • Shira Joudan

Nature Careers

Science jobs