An artistic representation of diene monomers and oligomers undergoing stereocontrolled ADMET through reaction with a Ru catalyst

Read our January issue

This month we have a Thesis on poster sessions at conferences, an In Your Element article focussing on sucrose and the usual fantastic mix of News and Views and Articles.


  • A Nobel medal in the foreground with some beakers and flasks in the background.

    The 2022 Nobel Prize in Chemistry has been awarded to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless for the development of click chemistry and bioorthogonal chemistry. In recognition of this award, Nature Portfolio presents a collection of research, review and opinion articles that focus on the origins, the development and the future directions inspired by the topic.

  • Nature Synthesis is open for submissions of original research articles. The journal will publish research, reviews and opinion articles on chemical and materials synthesis as well as enabling technological innovations.

  • COVID-19 and impact on peer review

    The COVID-19 pandemic is causing significant disruption and we are very aware that many researchers will have difficulty in meeting the standard timelines for our peer-review process. Please let us know if you need additional time. Our systems will continue to remind you of the original deadlines but we will be highly flexible as required.

Nature Chemistry is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

Our Open Access option complies with funder and institutional requirements.


  • X-ray diffraction is crucial for the phase elucidation of polycrystalline materials but remains challenging for complex multiphase systems. Now serial rotation electron diffraction has been shown to enable rapid, reliable and semiquantitative phase analysis of such systems, facilitating high-throughput screening of complex synthesis systems and providing new opportunities for materials development.

    • Yi Luo
    • Bin Wang
    • Xiaodong Zou
    Article Open Access
  • Neutral homoaromatic hydrocarbons—which possess an interrupted π-system yet display aromatic properties owing to through-space or through-bond interactions—have remained rare as they are typically unstable. Now a class of stable neutral homoaromatic homoannulenes has been synthesized, including one that acts as a photoswitch through a reversible [1, 11] sigmatropic rearrangement.

    • Trung Tran Ngoc
    • Niklas Grabicki
    • Johannes F. Teichert
    Article Open Access
  • Current strategies for photoinduced olefin metathesis lack wavelength tunability. Now, plasmonic nanoparticles have been used to activate latent ruthenium catalysts, enabling light-induced olefin metathesis in the infrared range with several advantages when compared with conventional heating. Implementing this approach in ring-opening metathesis polymerization resulted in photoresponsive polymer–nanoparticle composites with enhanced mechanical properties.

    • Nir Lemcoff
    • Noy B. Nechmad
    • Yossi Weizmann
  • Mechanochemical generation of dyes with different photophysical properties generally requires the use of discrete mechanophore derivatives with unique chemical structures. Now it has been shown that diverse donor–acceptor Stenhouse adducts can be produced via a mechanically gated chromogenic reaction, enabling mechanochemical multicolour lithography.

    • Anna C. Overholts
    • Wendy Granados Razo
    • Maxwell J. Robb
  • Cycloaddition reactions are among the most useful reactions in chemical synthesis, but biosynthetic enzymes with 2 + 2 cyclase activity have yet to be observed. Now it is shown that a β-barrel-fold protein catalyses competitive 2 + 2 and 4 + 2 cycloaddition reactions. This protein can be engineered to preferentially produce the exo-2 + 2, exo-4 + 2 or endo-4 + 2 product.

    • Hongbo Wang
    • Yike Zou
    • K. N. Houk
  • The direct conversion of sulfones to chiral sulfinyl compounds is one of the major challenges in the fields of asymmetric synthesis and organosulfur chemistry. Now, through incorporation of a cyano group into the sulfone, an organocatalytic asymmetric deoxygenation strategy has been developed that enables the synthesis of chiral sulfinyl compounds.

    • Shengli Huang
    • Zhen Zeng
    • Hailong Yan
    • 2+2-cycloaddition reactions have long been considered key transformations in the biosynthesis of cyclobutane-containing natural products, but enzymes for these reactions have not yet been identified. Now, a 2+2 cyclase has been discovered, characterized and bioengineered to catalyse cycloadditions with different selectivity.

      • Bo Zhang
      • Hui Ming Ge
      News & Views
    • The selective removal of one oxygen atom from sulfones, without over-reduction to sulfide, is a challenging task. Now, through organocatalysis and incorporation of a cyano group into the sulfone, an asymmetric deoxygenation strategy has been developed, providing an efficient method for the synthesis of chiral sulfinyl compounds.

      • Elżbieta Wojaczyńska
      • Jacek Wojaczyński
      News & Views
    • Interlocking macrocyclic carbon nanomaterials is an exciting way to tune their molecular properties, but all-conjugated catenanes and rotaxanes are extremely challenging to make. Now, fully π-conjugated [2]- and [3]catenanes as well as a [3]rotaxane have been prepared through an ‘active metal template’ approach.

      • Satyajit Das
      • Fredrik Schaufelberger
      News & Views
    • Ribosomes cannot synthesize peptides using hydroxy acids to replace canonical amino acids as no codons encode hydroxy acid building blocks. Now, this challenge has been addressed by rewriting the genetic code, enabling the direct cellular biosynthesis of non-natural depsipeptides containing non-canonical amino acids.

      • Jian Li
      News & Views
    • Molecular computing programmed with complementary nucleic acid strands allows the construction of sophisticated biomolecular circuits. Now, systems with partially complementary strands have been shown to enable more compact and faster molecular circuits, and may illuminate biological processes.

      • Philip Petersen
      • Grigory Tikhomirov
      News & Views
  • Methane hydrate clogs pipelines, is difficult to extract profitably, and exists in quantities sufficient to screw up Earth’s climate. Brett Thornton and Christian Stranne consider this confounding cage compound.

    • Brett F. Thornton
    • Christian Stranne
    In Your Element
  • Amilra Prasanna (AP) de Silva talks to Nature Chemistry about his path in chemistry, from photochemistry to sodium sensors to logic gates, through connections between people and between two places that share more than it may seem, Sri Lanka and Northern Ireland.

    • Anne Pichon
  • Carina Crucho and Maria Teresa Barros consider the rich chemistry of sucrose, a carbohydrate that makes life sweeter.

    • Carina I. C. Crucho
    • Maria Teresa Barros
    In Your Element
  • Introduced in response to growing numbers of scientists and conferences, posters gave an outlet to those not invited to give oral presentations. But why are poster sessions still the purview of students?

    • Michelle Francl
  • Abhik Ghosh explores the structure, chemistry and applications of corroles, a class of sterically constrained macrocyclic tetrapyrroles.

    • Abhik Ghosh
    In Your Element
  • Sit back and settle in for a tour of the chemical analysis instruments aboard the James Webb Space Telescope and the techniques being used to explore the planets beyond our Solar System.

    • Bruce C. Gibb

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