Artistic representation based on modelling of catenanes and rotaxanes.

Read our February issue

This month we have a Q+A with AP de Silva, a Thesis article on the marvellous (but misunderstood) mushroom and an In Your Element article focussing on methane hydrate.


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    The 2022 Nobel Prize in Chemistry has been awarded to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless for the development of click chemistry and bioorthogonal chemistry. In recognition of this award, Nature Portfolio presents a collection of research, review and opinion articles that focus on the origins, the development and the future directions inspired by the topic.

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  • X-ray diffraction is crucial for the phase elucidation of polycrystalline materials but remains challenging for complex multiphase systems. Now serial rotation electron diffraction has been shown to enable rapid, reliable and semiquantitative phase analysis of such systems, facilitating high-throughput screening of complex synthesis systems and providing new opportunities for materials development.

    • Yi Luo
    • Bin Wang
    • Xiaodong Zou
    Article Open Access
  • Neutral homoaromatic hydrocarbons—which possess an interrupted π-system yet display aromatic properties owing to through-space or through-bond interactions—have remained rare as they are typically unstable. Now a class of stable neutral homoaromatic homoannulenes has been synthesized, including one that acts as a photoswitch through a reversible [1, 11] sigmatropic rearrangement.

    • Trung Tran Ngoc
    • Niklas Grabicki
    • Johannes F. Teichert
    Article Open Access
  • Current strategies for photoinduced olefin metathesis lack wavelength tunability. Now, plasmonic nanoparticles have been used to activate latent ruthenium catalysts, enabling light-induced olefin metathesis in the infrared range with several advantages when compared with conventional heating. Implementing this approach in ring-opening metathesis polymerization resulted in photoresponsive polymer–nanoparticle composites with enhanced mechanical properties.

    • Nir Lemcoff
    • Noy B. Nechmad
    • Yossi Weizmann
  • Mechanochemical generation of dyes with different photophysical properties generally requires the use of discrete mechanophore derivatives with unique chemical structures. Now it has been shown that diverse donor–acceptor Stenhouse adducts can be produced via a mechanically gated chromogenic reaction, enabling mechanochemical multicolour lithography.

    • Anna C. Overholts
    • Wendy Granados Razo
    • Maxwell J. Robb
  • Cycloaddition reactions are among the most useful reactions in chemical synthesis, but biosynthetic enzymes with 2 + 2 cyclase activity have yet to be observed. Now it is shown that a β-barrel-fold protein catalyses competitive 2 + 2 and 4 + 2 cycloaddition reactions. This protein can be engineered to preferentially produce the exo-2 + 2, exo-4 + 2 or endo-4 + 2 product.

    • Hongbo Wang
    • Yike Zou
    • K. N. Houk
  • The direct conversion of sulfones to chiral sulfinyl compounds is one of the major challenges in the fields of asymmetric synthesis and organosulfur chemistry. Now, through incorporation of a cyano group into the sulfone, an organocatalytic asymmetric deoxygenation strategy has been developed that enables the synthesis of chiral sulfinyl compounds.

    • Shengli Huang
    • Zhen Zeng
    • Hailong Yan
    • Post-translational modification of proteins is widely used for studying biological processes; however, competing reactions can provide numerous challenges. Now, a visible-light photocatalytic diselenide contraction enables the highly chemoselective functionalization of selenopeptides and proteins under mild conditions.

      • Nicholas A. Fitzpatrick
      • Patricia Z. Musacchio
      News & Views
    • 2+2-cycloaddition reactions have long been considered key transformations in the biosynthesis of cyclobutane-containing natural products, but enzymes for these reactions have not yet been identified. Now, a 2+2 cyclase has been discovered, characterized and bioengineered to catalyse cycloadditions with different selectivity.

      • Bo Zhang
      • Hui Ming Ge
      News & Views
    • The selective removal of one oxygen atom from sulfones, without over-reduction to sulfide, is a challenging task. Now, through organocatalysis and incorporation of a cyano group into the sulfone, an asymmetric deoxygenation strategy has been developed, providing an efficient method for the synthesis of chiral sulfinyl compounds.

      • Elżbieta Wojaczyńska
      • Jacek Wojaczyński
      News & Views
    • Interlocking macrocyclic carbon nanomaterials is an exciting way to tune their molecular properties, but all-conjugated catenanes and rotaxanes are extremely challenging to make. Now, fully π-conjugated [2]- and [3]catenanes as well as a [3]rotaxane have been prepared through an ‘active metal template’ approach.

      • Satyajit Das
      • Fredrik Schaufelberger
      News & Views
    • Ribosomes cannot synthesize peptides using hydroxy acids to replace canonical amino acids as no codons encode hydroxy acid building blocks. Now, this challenge has been addressed by rewriting the genetic code, enabling the direct cellular biosynthesis of non-natural depsipeptides containing non-canonical amino acids.

      • Jian Li
      News & Views
  • Winter brings a spike in mortality rates, but rather than simply having more parties to divert our attention, Bruce Gibb suggests that perhaps we should be looking to the misunderstood mushroom to give us a boost.

    • Bruce C. Gibb
  • Methane hydrate clogs pipelines, is difficult to extract profitably, and exists in quantities sufficient to screw up Earth’s climate. Brett Thornton and Christian Stranne consider this confounding cage compound.

    • Brett F. Thornton
    • Christian Stranne
    In Your Element
  • Amilra Prasanna (AP) de Silva talks to Nature Chemistry about his path in chemistry, from photochemistry to sodium sensors to logic gates, through connections between people and between two places that share more than it may seem, Sri Lanka and Northern Ireland.

    • Anne Pichon
  • Carina Crucho and Maria Teresa Barros consider the rich chemistry of sucrose, a carbohydrate that makes life sweeter.

    • Carina I. C. Crucho
    • Maria Teresa Barros
    In Your Element
  • Introduced in response to growing numbers of scientists and conferences, posters gave an outlet to those not invited to give oral presentations. But why are poster sessions still the purview of students?

    • Michelle Francl
  • Abhik Ghosh explores the structure, chemistry and applications of corroles, a class of sterically constrained macrocyclic tetrapyrroles.

    • Abhik Ghosh
    In Your Element

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