There are lots of expectations for assistant professors, and many opportunities that are good for your career. Shira Joudan reflects on making a personalized reference document for how to decide which opportunities are best to pursue, and to which to say ‘no’.

Fires are relatively common yet underreported occurrences in chemical laboratories, but their consequences can be devastating. Here we describe our first-hand experience of a savage laboratory fire, highlighting the detrimental effects that it had on the research group and the lessons learned.

Critical realism distinguishes the ‘real’ world from the ‘observable’ one, which scientists explore as actors rather than as passive, neutral observers. Through this lens, it is clear that a diverse community that interrogates the world from different angles is an asset to the practice of chemistry itself.

Critical race theory — an academic framework that serves to understand systemic racism in the USA and beyond — can help inform endeavours to advance justice and equity in the chemistry community.

The reversible N–H activation and catalytic transformations of ammonia are a challenge. Now, a hidden frustrated Lewis pair is shown to activate non-aqueous ammonia thermoneutrally and split the N–H bond reversibly at ambient temperature. The N–H-activated ammonia was also utilized as an atom-economical nitrogen source for catalytic NH₃ transfer reactions.

Although amorphous calcium carbonate represents an important biomineralization precursor, its structure has been difficult to understand. Now, amorphous calcium carbonate’s structure is shown to arise from the different bridging modes available to the calcium ions. This effective multi-well potential that drives calcium arrangements creates a geometric incompatibility between preferred Ca–Ca distances and frustrates crystallization.

Understanding of the molecular mechanisms underlying the maturation of protein condensates into amyloid fibrils associated with neurodegenerative diseases has so far remained elusive. Now it has been shown that in condensates formed by the low-complexity domain of the amyotrophic lateral sclerosis-associated protein hnRNPA1, fibril formation is promoted at the interface, which provides a potential therapeutic target for counteracting aberrant protein aggregation.

While aromaticity is a useful concept for assessing the reactivity of organic compounds, the connection between aromaticity and on-surface chemistry remains largely unexplored. Now, scanning probe experiments on cyclization reactions of porphyrins on Au(111) show that the peripheral carbon atoms outside of the aromatic 18-π electron pathway exhibit a higher reactivity.

Covalent organic frameworks offer a highly tunable class of materials for a range of applications, although their dynamic structural transformations are challenging to analyse. Now single-crystal X-ray diffraction is shown to demonstrate single-crystal-to-single-crystal transformations of the imine linkages, showing a well-defined interpenetrating topology and affording structures that have high positive thermal expansion and anhydrous proton-conduction properties.

Shifts in temperature alter the structure and dynamics of macromolecules. Now, infra-red laser-induced temperature jump is combined with X-ray crystallography to observe protein structural dynamics in real time. Using this method, motions related to the catalytic cycle of lysozyme, a model enzyme, are visualized at atomic resolution and across broad timescales.

Few explosives are better-known to non-chemists than trinitrotoluene (TNT). Thomas M. Klapötke reflects on the enduring appeal of TNT and whether its starring role as an explosive is nearing its end.

Teaching the history of science along with the science itself can give students greater context about the topic they are learning and a wider perspective on how it has developed. Michelle Francl, who has wrestled with how much time to spend on teaching history in the chemistry classroom for years, considers how unconventional histories can shift the curriculum.

Clinton Veale and Fanie van Heerden discuss the story of natamycin. From its humble telluric origins in Pietermaritzburg, this unique antimicrobial agent has risen to become a mainstay of the food and beverages industry.

There are lots of expectations for assistant professors, and many opportunities that are good for your career. Shira Joudan reflects on making a personalized reference document for how to decide which opportunities are best to pursue, and to which to say ‘no’.

Different roles require different types of intelligences, and trainee chemists are often tested on their linguistic and logical–mathematical intelligences at the expense of other types. Bruce Gibb describes the types of intelligences that chemists use, and suggests ways to teach and test them.

Fiona C. Meldrum and Helmut Cölfen chalk up some of the myriad forms and uses of calcium carbonate to burnish a ‘dull’ reputation.