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Volume 7 Issue 9, September 2005

Release of phospho-caveolin-1 (red) from focal adhesions (vinculin in green) stimulates integrin-mediated internalization of membrane microdomains.

Volume 7 Issue 9

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Editorial

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  • How proteins exit the Golgi apparatus on their way to the plasma membrane is poorly understood. Protein kinase D (PKD) is known to regulate this process, but its downstream targets have remained elusive. New work now identifies a previously known player in Golgi dynamics — phosphatidylinositol 4-kinase IIIβ — as a physiological PKD substrate.

    • Yashoda Ghanekar
    • Martin Lowe
    News & Views

  • Myosin-V transports intracellular cargo along an actin filament, using a 'hand-over-hand' mechanism that moves it forward in 36-nm steps before dissociating. To achieve long run lengths, the stepping of the two myosin heads must be coordinated. Recent evidence favours the idea that this coordination is achieved by intramolecular strain between the heads, so that myosin prefers to pick up its trailing head first to search for a new actin-binding site, and move cargo forward on the actin.

    • Kathleen M. Trybus
    News & Views

  • The human genome encodes at least 70 Rab GTPases and more than 50 putative Rab GTPase-activating proteins (GAPs). An elegant scheme to rapidly identify the Rab target for each of these GAPs has led to the identification of a potent Rab GAP for Rab5.

    • Suzanne Pfeffer
    News & Views

  • Asymmetric cell division is a fundamental process by which cells give rise to progenies with different fates. Although this mechanism is well studied in the worm and fly, mammalian asymmetric cell division is poorly understood. The finding that Gβγ and AGS3 can control mitotic spindle orientation and progenitor cell fates during mouse cortical development suggests evolutionarily conserved roles in asymmetric cell division.

    • Chay T. Kuo
    • Yuh-Nung Jan
    News & Views
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