Volume 6 Issue 6, June 2004

Volume 6 Issue 6

Formation of myosin-X-induced filopodia depends on integrins. GFPmyosin (green) caused a remarkable induction of filopodia in an integrin dependent manner. Actin staining is shown in red. Cover design: Lawrence Keogh



  • Commentary |

    Generating and maintaining features that distinguish one organelle from another is essential for accurate membrane traffic. Recent work has revealed that organelles express 'identity' by the local generation of activated GTP-binding proteins and lipid species. These recruiting determinants are then recognized by cytosolic proteins that facilitate the formation and delivery of vesicles at the correct compartment.

    • Sean Munro

News and Views

  • News & Views |

    Sister chromatid segregation in anaphase of mitosis is initiated through cleavage of cohesin by the protease separase. Two studies now show that this view is valid for most chromosomal DNA, but not for the highly repetitive ribosomal DNA (rDNA) and telomeres. The disjunction of these regions of the chromosome occurs in mid-anaphase, long after cohesin cleavage, and is regulated by the conserved phosphatase Cdc14.

    • Gislene Pereira
    •  & Elmar Schiebel
  • News & Views |

    Synaptic vesicle exocytosis, a finely tuned process that results in rapid neurotransmitter release, is still not fully understood. Studies in a simple reconstituted lipid bilayer system have now definitively demonstrated that synaptotagmin has a key role in calcium-mediated exocytosis and have also revealed additional aspects of exocytic fusion.

    • Jacopo Meldolesi
    •  & Evelina Chieregatti
  • News & Views |

    Metalloproteases are required for the invasive nature of cancer cells. Surprisingly, the cytosolic molecular chaperone Hsp90 is now shown to promote maturation of the extracellular metalloprotease MMP2. This finding extends the multiplicity of roles assigned to the Hsp90 family to a new function outside the cell.

    • Didier Picard

Book Review

Historical Perspective


Meeting Report

News and Views




  • Focus |

    Focus on membrane traffic

    This section contains all material on the topic of membrane traffic published in Nature Cell Biology to date including original research papers, Reviews, Perspectives, Commentaries and News and Views. View the current focus issue from June 2004, and an earlier focus issue from October 1999.