Volume 6 Issue 2, February 2004

Volume 6 Issue 2

The tumour suppressor RASSF1A localizes to microtubules. Cells expressing HA-tagged RASSF1A (green), were co-stained with anti-b-tubulin (red). cover design: James McQuat

Editorial

Book Review

Meeting Report

News and Views

  • News & Views |

    In the post-genome era, there is increasing interest in developing quantitative models of cell function at the molecular level. Although data describing the role of individual proteins in cell behaviour remain rate-limiting for such efforts, large-scale screening approaches are providing results that can be used to map the protein–protein interactions of a living biological system.

    • Matthew S. Hayden
    •  & Sankar Ghosh
  • News & Views |

    Genotoxic stress induces a survival response by releasing the transcription factor NF-κB from its inhibitor IκBα. In response to DNA damage, this initially requires the nuclear modification of the IκB kinase regulator NEMO/IKKγ by SUMO and ubiquitin.

    • Ronald T. Hay
  • News & Views |

    Specific gene expression patterns must be tightly regulated for eukaryotic cells to acquire unique structural and functional features. A key step is transcriptional initiation, during which epigenetic activators are thought to facilitate the process by establishing and maintaining transcription-competent chromatin structures. Accumulating evidence shows that an epigenetic regulator can also control the next step — transcriptional elongation.

    • Tilman Sanchez-Elsner
    •  & Frank Sauer
  • News & Views |

    The kinetochore attaches the centromeric region of chromosomes to spindle microtubules, allowing equatorial chromosome segregation during mitosis. Proteomic analyses suggest that the kinetochore is a supramolecular complex containing more than 65 proteins that surpasses the size of a ribosome. From within this complex web, stable protein sub-complexes have been extracted, revealing the building blocks for kinetochore assembly.

    • Vivien Measday
    •  & Philip Hieter

Article

  • Article |

    • Tewis Bouwmeester
    • , Angela Bauch
    • , Heinz Ruffner
    • , Pierre-Olivier Angrand
    • , Giovanna Bergamini
    • , Karen Croughton
    • , Cristina Cruciat
    • , Dirk Eberhard
    • , Julien Gagneur
    • , Sonja Ghidelli
    • , Carsten Hopf
    • , Bettina Huhse
    • , Raffaella Mangano
    • , Anne-Marie Michon
    • , Markus Schirle
    • , Judith Schlegl
    • , Markus Schwab
    • , Martin A. Stein
    • , Andreas Bauer
    • , Georg Casari
    • , Gerard Drewes
    • , Anne-Claude Gavin
    • , David B. Jackson
    • , Gerard Joberty
    • , Gitte Neubauer
    • , Jens Rick
    • , Bernhard Kuster
    •  & Giulio Superti-Furga

Letters

Brief Communication