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Volume 22 Issue 2, February 2020

Volume 22 Issue 2

RNA

piRNAs regulate fertility via epigenetic silencing

See Barucci et al..

Image: [Image courtesy of Eric Cornes, Institut Pasteur, Paris]. Cover Design: [Lauren Heslop].

News & Views

  • News & Views |

    A mechanism of secretory autophagy explains aspects of the packaging of proteins and RNA into extracellular vesicles and paves the way to a better understanding of their biological roles and medical applications.

    • Janusz Rak
  • News & Views |

    Understanding the metabolic rewiring of pancreatic ductal adenocarcinoma is an emerging strategy for identifying cancer-associated liabilities and improving treatment. A new study now elucidates the function of the transaminase BCAT2 in the early stages of tumor development, providing insights that could stimulate novel therapeutic strategies.

    • Mattia Falcone
    • Oliver D. K. Maddocks
  • News & Views |

    The ribosome decodes messenger RNAs and constructs proteins based on the genetic blueprint. Ribosomes also associate with non-coding RNAs, such as PIWI-interacting RNA (piRNA) precursors, during the meiotic pachytene stage. Intriguingly, the ribosome mediates pachytene piRNA biogenesis by guiding endonucleolytic cleavage of piRNA precursors.

    • Yuanhui Mao
    • Shu-Bing Qian

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