Volume 21 Issue 7, July 2019

Volume 21 Issue 7

Cytoskeleton

Suppression of rhoGAPs by G-actin

See Diring et al.

Image: Jessica Diring (The Francis Crick Institute) and Jeroen Claus (Phospho Biomedical Animation). Cover Design: Lauren Heslop.

News & Views

  • News & Views |

    Tumour-secreted microvesicles carry bioactive molecules that can be transferred to recipient cells, impacting tumour progression. A study now shows that ARF6 drives miRNA loading into tumour microvesicles through interaction with pre-miRNA–Exportin-5 complexes, thus shedding light on specific cargo packaging mechanisms.

    • Gonçalo Rodrigues
    • , Haiying Zhang
    •  & David Lyden
  • News & Views |

    Different subclones cooperate to support tumour heterogeneity and growth, but the effect on metastasis is unclear. A new study now shows that, as non-cell-autonomous drivers, minor cancer cell subclones instigate growth at distant sites of otherwise non-metastatic cancer cells. This is mediated systemically by perturbation in the metastatic tissue.

    • Luigi Ombrato
    •  & Ilaria Malanchi
  • News & Views |

    The ability of cancer cells to adapt to external and internal stresses is critical for tumourigenesis. A new study now shows that the integrated stress response is critical for tumour cell adaptation to stress induced by c-MYC activation, providing mechanistic insights into tumour responses to intrinsic stresses with implications for cancer therapies.

    • Kirk A. Staschke
    •  & Ronald C. Wek

Review Articles

  • Review Article |

    In this Review, the authors survey key advances in stem cell research and describe the cell types that are currently being used in the clinic or are close to clinical trials.

    • Michele De Luca
    • , Alessandro Aiuti
    • , Giulio Cossu
    • , Malin Parmar
    • , Graziella Pellegrini
    •  & Pamela Gehron Robey

Articles

  • Article |

    Sigal et al. report that Rspo3 regulates Lgr5 cells in the gastric gland base, induces their differentiation into secretory cells and stimulates epithelial antimicrobial defence against H. pylori infection.

    • Michael Sigal
    • , Maria del Mar Reinés
    • , Stefanie Müllerke
    • , Cornelius Fischer
    • , Marta Kapalczynska
    • , Hilmar Berger
    • , Elvira R. M. Bakker
    • , Hans-Joachim Mollenkopf
    • , Michael E. Rothenberg
    • , Bertram Wiedenmann
    • , Sascha Sauer
    •  & Thomas F. Meyer
  • Article |

    Tian et al. report that the chromatin-related factor Whsc1 regulates the exit from pluripotency and germ layer specification of mouse embryonic stem cells by binding to enhancers of mesendodermal regulators.

    • Tian V. Tian
    • , Bruno Di Stefano
    • , Grégoire Stik
    • , Maria Vila-Casadesús
    • , José Luis Sardina
    • , Enrique Vidal
    • , Alessandro Dasti
    • , Carolina Segura-Morales
    • , Luisa De Andrés-Aguayo
    • , Antonio Gómez
    • , Johanna Goldmann
    • , Rudolf Jaenisch
    •  & Thomas Graf
  • Article |

    Clancy et al. delineate a pathway for pre-miRNA delivery into nascent extracellular vesicles released from tumour cells and show that shed vesicles contain machinery allowing cell-free pre-miRNA processing.

    • James W. Clancy
    • , Ye Zhang
    • , Colin Sheehan
    •  & Crislyn D’Souza-Schorey
  • Article |

    Janiszewska et al. show that minor subpopulations expressing IL11 and FIGF in breast cancer cells promote metastasis through altering local and systemic tumour microenvironments including neutrophils.

    • Michalina Janiszewska
    • , Doris P. Tabassum
    • , Zafira Castaño
    • , Simona Cristea
    • , Kimiyo N. Yamamoto
    • , Natalie L. Kingston
    • , Katherine C. Murphy
    • , Shaokun Shu
    • , Nicholas W. Harper
    • , Carlos Gil Del Alcazar
    • , Maša Alečković
    • , Muhammad B. Ekram
    • , Ofir Cohen
    • , Minsuk Kwak
    • , Yuanbo Qin
    • , Tyler Laszewski
    • , Adrienne Luoma
    • , Andriy Marusyk
    • , Kai W. Wucherpfennig
    • , Nikhil Wagle
    • , Rong Fan
    • , Franziska Michor
    • , Sandra S. McAllister
    •  & Kornelia Polyak
  • Article |

    Activating transcription factor 4 (ATF4) promotes MYC-driven tumour progression. Tameire et al. identify ATF4 and its target eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) as regulators of MYC-mediated amino acid biosynthesis and protein synthesis, thereby modulating tumour progression and survival in mice.

    • Feven Tameire
    • , Ioannis I. Verginadis
    • , Nektaria Maria Leli
    • , Christine Polte
    • , Crystal S. Conn
    • , Rani Ojha
    • , Carlo Salas Salinas
    • , Frank Chinga
    • , Alexandra. M. Monroy
    • , Weixuan Fu
    • , Paul Wang
    • , Andrew Kossenkov
    • , Jiangbin Ye
    • , Ravi K. Amaravadi
    • , Zoya Ignatova
    • , Serge Y. Fuchs
    • , J. Alan Diehl
    • , Davide Ruggero
    •  & Constantinos Koumenis

Technical Reports

  • Technical Report |

    Simunovic et al. use human embryonic stem cells to generate a three-dimensional model of a human pre-gastrulation epiblast and show that anterior–posterior symmetry breaking can be induced by BMP4 and WNT signalling.

    • Mijo Simunovic
    • , Jakob J. Metzger
    • , Fred Etoc
    • , Anna Yoney
    • , Albert Ruzo
    • , Iain Martyn
    • , Gist Croft
    • , Dong Shin You
    • , Ali H. Brivanlou
    •  & Eric D. Siggia

Amendments & Corrections