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Volume 21 Issue 6, June 2019

Volume 21 Issue 6


ER–mitochondrial contacts sustain bioenergetics

See Carreras-Sureda et al. and News & Views by Graier

Image: Felipe G. Serrano, scientific designer ( Cover Design: Lauren Heslop.

News & Views

  • News & Views |

    Yap signalling is crucial for intestinal regeneration, but its role is largely dispensable in homeostasis. Two studies now reveal Yap-dependent mechanisms of intestinal regeneration and tissue organization: transient expansion of a rare cell type after damage in vivo and Notch–Dll activation for symmetry breaking in organoid development.

    • Vivian S. W. Li
  • News & Views |

    IRE1α is an endoplasmic reticulum (ER) transmembrane protein known for a crucial role in regulating the unfolding protein response. A study now shows that IRE1α interacts with the main ER Ca2+ channel InsP3Rs and facilitates the transfer of Ca2+ from the ER into mitochondria, thus driving cellular metabolism.

    • Roland Malli
    • Wolfgang F. Graier
  • News & Views |

    Centromere identity must be maintained through multiple generations. A new study reveals a Constitutive Centromere-Associated Network (CCAN)-dependent retention of CENP-A, a key epigenetic mark for centromeres, in centromeres during DNA replication and a replication-dependent error correction to eliminate ectopic CENP-A in chromosome arms.

    • Masatoshi Hara
    • Tatsuo Fukagawa
  • News & Views |

    Embryonic stem cells derived from the inner cell mass can differentiate to all embryonic lineages of any adult cell type and to a limited extent to extra-embryonic tissues. A study now allows the generation of pig and human stem cells with enhanced differentiation potential towards all embryonic and extra-embryonic fates, one step closer to the totipotent state of the fertilized egg.

    • Fred Etoc
    • Ali Brivanlou


Technical Reports

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