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Volume 21 Issue 5, May 2019

Volume 21 Issue 5

Cytoskeleton

Actin and myosin II promote mitochondrial fission

See Yang and Svitkina.

Image: Image courtesy of Changsong Yang and Tatyana M. Svitkina, University of Pennsylvania. Cover Design: Lauren Heslop.

Editorial

  • Editorial |

    RNA molecules are more than messengers between DNA and protein and exhibit rich regulatory functions in development and disease. In this issue, we present a Focus on regulatory RNAs with specially commissioned Review articles that discuss recent advances in this fast-growing area.

News & Views

  • News & Views |

    Components of the spliceosome are frequently mutated in haematopoietic malignancies. Identification of mis-spliced genes promoting transformation will uncover novel targeted therapies. Now, a long isoform of IRAK4 is shown to be upregulated in a subset of acute myeloid leukaemia patients, conferring susceptibility for IRAK4 inhibition therapy.

    • Maria Guillamot
    • Iannis Aifantis
  • News & Views |

    Rag GTPases play a crucial role in mTORC1 activation by promoting its recruitment to the lysosomal surface in a nutrient-dependent manner. A study now identifies a family of lysosomal G-protein-coupled receptors as modulators of Rag GTPases localization and activation, adding one more component to the fast-growing mTOR regulatory network.

    • Rosa Puertollano
  • News & Views |

    Haematopoietic stem cells (HSCs) are maintained in vivo by intrinsic programs and extrinsic niche signals. Ex vivo expansion of HSCs is limited, owing to reduced stem cell maintenance factors. A study now shows that rejuvenated niche cells can be obtained by transcriptional rewiring of specific genes that maintain and expand HSCs ex vivo.

    • Aparna Venkatraman
    • Linheng Li

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