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Volume 21 Issue 3, March 2019

Mechanobiology

The Golgi links contractility to lipid synthesis

See Romani et al. and News & Views by Thery

Image: Image courtesy of Patrizia Romani and Sirio Dupont. Cover Design: Lauren Heslop.

News & Views

  • Healthy and malignant haematopoietic stem cells (HSCs) must overcome a variety of cell intrinsic and extrinsic stresses to maintain their functionality. Now, IRE1α –XBP1 signalling is shown to protect HSCs and to promote survival of, and confer competitive advantages to, NRAS-mutated pre-leukaemic cells.

    • Marina Scheller-Wendorff
    • Carsten Müller-Tidow
    News & Views

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  • Epithelial–mesenchymal transition (EMT) is crucial for development, and for dissemination and invasion of cancer cells. A study now identifies the apical–basolateral polarity status of epithelia as a checkpoint for EMT induction and tumour metastasis through aPKC–Par3-regulated degradation of the EMT transcription factor SNAI1.

    • Oana-Diana Persa
    • Carien M. Niessen
    News & Views
  • Cell metabolism ensures that cell dynamics and continued renewal are supported by a constant flow of matter that consumes energy. A new study shows that cell metabolism is sensitive to mechanical cues, revealing that the level of cell contraction modulates the production and storage of lipids, which could serve as fuel for energy production.

    • Manuel Théry
    • Mario Pende
    News & Views
  • Ancestral experience of mitochondrial stress is now found to render progeny of the roundworm Caenorhabditis elegans more resistant to the same insult for up to four generations. A DNA modification, N6-methyldeoxyadenine, is implicated in the inheritance of this stress adaptation.

    • Sarah-Lena Offenburger
    • Marcos Francisco Perez
    • Ben Lehner
    News & Views
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