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cover image Video confocal analysis of a human osteocarcinoma cell stably expressing GFP–actin 12 h after infection with vaccinia virus. Consecutive video frames 10 s apart are false-coloured blue, green and red to facilitate visualization of the actin-based movement of the virus. The video sequence was recorded during the 1999 EMBO course on ‘Biophysical and mathematical approaches to cell biology’ at EMBL by E. Stelzer, F. Frischknecht and M. Way. [Cover design: Majo Xeridat] [article, p.441]