Volume 2 Issue 10, October 2000

Volume 2 Issue 10

Drosophila wing imaginal disc. Several clones of cells lacking the schnurri product are shown by the absence of green fluorescent protein expression. In these mutant cells, expression of brinker is strongly upregulated, whereas spalt expression (as indicated by blue colouration) is lost. [Cover design: Majo Xeridat] [article, p745]

Articles

Brief Communications

Editorial

Letters to Editor

  • Letters to Editor |

    • John C. Reed
    • , Shigemi Matsuyama
    • , Quinn L. Deveraux
    • , Juan Llopis
    •  & Roger Tsien

News and Views

  • News & Views |

    Regulated ubiquitin/proteasome-dependent processing controls transcription by triggering the release of dormant transcriptional activators from the endoplasmic reticulum. This intersection of transcription and proteolysis has important implications for gene control, proteasome–substrate interactions and signal integration.

    • William P. Tansey
  • News & Views |

    Combined efforts of developmental biologists and cancer geneticists have outlined the canonical Wnt/Wingless (Wg) signalling pathway as we currently know it. At the heart of the pathway is the molecule β-catenin/Armadillo. Recent work has shown that the tumour suppressor adenomatous polyposis coli (APC) acts to shuttle β-catenin from the nucleus to the cytoplasm.

    • Hans Clevers
  • News & Views |

    Moving proteins between cellular locations is proving to be a tightly regulated process, and provides an important mechanism for controlling protein function. The tumour-suppressor protein p53 has been shown to use microtubules to aid nuclear localization, a finding that raises interesting questions about the action of microtubule-disrupting chemotherapeutic drugs.

    • Karen H. Vousden
    •  & George F. Vande Woude
  • News & Views |

    Protein kinases play an integral role in the regulation of virtually every major cellular and developmental process, and an understanding of how protein kinases function in vivo is therefore of central importance to cell biology. Newly developed protein-kinase inhibitors provide powerful tools for understanding the functions of kinases in vivo.

    • Doug Kellogg
  • News & Views |

    The catenin p120 protein functions as a traffic light at the crossroads between cell–cell adhesion and cell migration. It can influence the choice between sessile and migratory behaviour by interfering with the function of RHO proteins.

    • Vania Braga

Meeting Report

Book Reviews

Review