Volume 19

  • No. 12 December 2017

    Membrane traffic. TBC1D23 is an adaptor protein required for the delivery of endosome-derived vesicles to the trans-Golgi.

    [letter p1424]

  • No. 11 November 2017

    Stem cells. Synthetic hydrogels support the expansion of viable human intestinal organoids from pluripotent stem cells and can be used as injectable vehicles for organoid engraftment and wound healing.p1326

  • No. 10 October 2017

    Cilia. Mapping the ciliary transition zone using STORM imaging defines the architecture of its key components.p1178

  • No. 9 September 2017

    Cell death. Caspase-independent cell death stimulates NF-κB activity through IAP down-regulation to enhance anti-tumour effects.

    [article p1116]

  • No. 8 August 2017

    Stem cells. Bone marrow adipocytes express high levels of SCF, which is essential for haematopoietic regeneration.p891

  • No. 7 July 2017

    Adult stem cells and cancer. Lgr5+ cells in the oxyntic stomach function as reserve stem cells during regeneration and as cells-of-origin of gastric cancer.

    [article p774]

  • No. 6 June 2017

    Cancer. Normal mammary stem cells and breast cancer stem cells evade the suppressive effects of macrophage-derived interferon through elevated expression of miR-199a, allowing the preservation of stem cell properties and the acquisition of tumour-initiating abilities.p711

  • No. 5 May 2017

    Metabolism. Bacteria–host interactions regulate metabolism through nuclear receptor and Hedgehog signalling.

    [letter p550]

  • No. 4 April 2017

    Stem cells. This multi-scale, single-cell study reveals that human haematopoietic stem cells continuously commit to individual blood cell lineages without passing through discrete progenitor stages. [article p271]

  • No. 3 March 2017

    Mechanotransduction across heterotypic adhesions between cancer cells and cancer-associated fibroblasts (CAFs) is required for CAFs to lead cancer cell invasion.

    [article p224]

  • No. 2 February 2017

    Hypoxia in the primary tumour microenvironment leads to upregulation of a dormancy signature in the tumour cells that persists after their dissemination to distant sites, permitting them to evade therapy.p120

  • No. 1 January 2017

    In vivo multicolour cell fate mapping allows detailed insights into early clonal events that regulate haematopoietic development in zebrafish.

    [article p17]