Volume 17 Issue 9, September 2015

Volume 17 Issue 9

YAP and TAZ cooperate with AP-1 to regulate gene expression that controls cell proliferation and oncogenic growth.

[resource p1218]

Perspective

  • Perspective |

    Microtubule polymerization is initiated by γ-tubulin containing complexes. Petry and Vale discuss factors involved in localizing and activating γ-tubulin at different locations in the cell.

    • Sabine Petry
    •  & Ronald D. Vale

News and Views

  • News & Views |

    Compared with most intracellular vesicles, the autophagosome is formed by an unusual event of vesicle budding involving an elusive sequence of membrane expansions that ends with a double membrane vesicle. It is now shown that actin polymerization inside the forming autophagosome is a driving force for the expansion and assembly of a functional autophagosome.

    • Petter Holland
    •  & Anne Simonsen
  • News & Views |

    A new study suggests that fumarase, a metabolic enzyme normally associated with ATP production in mitochondria, is recruited to sites of DNA damage where it produces fumarate to inhibit histone demethylation and promote repair of DNA double strand breaks.

    • Susan P. Lees-Miller

Articles

  • Article |

    By analysing inducible knockout mice, Scherer and colleagues report that the adipogenic transcription factor C/EBPα is dispensable for white adipogenesis in mouse embryos, but not in adults.

    • Qiong A. Wang
    • , Caroline Tao
    • , Lei Jiang
    • , Mengle Shao
    • , Risheng Ye
    • , Yi Zhu
    • , Ruth Gordillo
    • , Aktar Ali
    • , Yun Lian
    • , William L. Holland
    • , Rana K. Gupta
    •  & Philipp E. Scherer
  • Article |

    Using light- and electron microscopy, Khodjakov, Mogilner and colleagues find that the shape of the kinetochore undergoes dramatic changes during mitosis. Computational analysis suggests that this facilitates correct chromosome attachment.

    • Valentin Magidson
    • , Raja Paul
    • , Nachen Yang
    • , Jeffrey G. Ault
    • , Christopher B. O’Connell
    • , Irina Tikhonenko
    • , Bruce F. McEwen
    • , Alex Mogilner
    •  & Alexey Khodjakov
  • Article |

    Anastasiadis and colleagues report the presence of two spatially and functionally distinct E-cadherin-based junctional complexes, which influence cell behaviour either by regulating miRNA processing or by promoting p120 catenin and Src signalling.

    • Antonis Kourtidis
    • , Siu P. Ngok
    • , Pamela Pulimeno
    • , Ryan W. Feathers
    • , Lomeli R. Carpio
    • , Tiffany R. Baker
    • , Jennifer M. Carr
    • , Irene K. Yan
    • , Sahra Borges
    • , Edith A. Perez
    • , Peter Storz
    • , John A. Copland
    • , Tushar Patel
    • , E. Aubrey Thompson
    • , Sandra Citi
    •  & Panos Z. Anastasiadis
  • Article |

    By screening 85 deubiquitylation enzymes, Zhang and colleagues identify OTUD3 as an enzyme that upregulates PTEN levels by deubiquitylation and acts as a tumour suppressor in synergy with another PTEN DUB, USP13.

    • Lin Yuan
    • , Yanrong Lv
    • , Hongchang Li
    • , Haidong Gao
    • , Shanshan Song
    • , Yuan Zhang
    • , Guichun Xing
    • , Xiangzhen Kong
    • , Lijing Wang
    • , Yang Li
    • , Tao Zhou
    • , Daming Gao
    • , Zhi-Xiong Xiao
    • , Yuxin Yin
    • , Wenyi Wei
    • , Fuchu He
    •  & Lingqiang Zhang
  • Article |

    Procopio et al. report that combined loss of p53 and the CSL transcriptional regulator leads to stromal and cancer cell expansion by bypassing the fibroblast senescence caused by CSL deficiency and promoting cancer-associated fibroblast activation.

    • Maria-Giuseppina Procopio
    • , Csaba Laszlo
    • , Dania Al Labban
    • , Dong Eun Kim
    • , Pino Bordignon
    • , Seung-Hee Jo
    • , Sandro Goruppi
    • , Elena Menietti
    • , Paola Ostano
    • , Ugo Ala
    • , Paolo Provero
    • , Wolfram Hoetzenecker
    • , Victor Neel
    • , Witold W. Kilarski
    • , Melody A. Swartz
    • , Cathrin Brisken
    • , Karine Lefort
    •  & G. Paolo Dotto
  • Article |

    Gil and colleagues report that mTOR affects the tumour-related effects of the senescence-associated secretory phenotype (SASP), by inhibiting the translation of the MAPKAPK2 kinase and thereby preventing the ZFP36L1-mediated SASP mRNA decay.

    • Nicolás Herranz
    • , Suchira Gallage
    • , Massimiliano Mellone
    • , Torsten Wuestefeld
    • , Sabrina Klotz
    • , Christopher J. Hanley
    • , Selina Raguz
    • , Juan Carlos Acosta
    • , Andrew J. Innes
    • , Ana Banito
    • , Athena Georgilis
    • , Alex Montoya
    • , Katharina Wolter
    • , Gopuraja Dharmalingam
    • , Peter Faull
    • , Thomas Carroll
    • , Juan Pedro Martínez-Barbera
    • , Pedro Cutillas
    • , Florian Reisinger
    • , Mathias Heikenwalder
    • , Richard A. Miller
    • , Dominic Withers
    • , Lars Zender
    • , Gareth J. Thomas
    •  & Jesús Gil

Resource

  • Resource |

    Piccolo and colleagues report that the YAP/TAZ factors form ternary complexes with TEAD and AP-1 factors to drive a transcriptional program that promotes cell proliferation and tumour growth.

    • Francesca Zanconato
    • , Mattia Forcato
    • , Giusy Battilana
    • , Luca Azzolin
    • , Erika Quaranta
    • , Beatrice Bodega
    • , Antonio Rosato
    • , Silvio Bicciato
    • , Michelangelo Cordenonsi
    •  & Stefano Piccolo

Corrigendum

  • Corrigendum |

    • Jing Liu
    • , Qingkai Han
    • , Tianran Peng
    • , Meixiu Peng
    • , Bei Wei
    • , Dongwei Li
    • , Xiaoshan Wang
    • , Shengyong Yu
    • , Jiaqi Yang
    • , Shangtao Cao
    • , Kaimeng Huang
    • , Andrew Paul Hutchins
    • , He Liu
    • , Junqi Kuang
    • , Zhiwei Zhou
    • , Jing Chen
    • , Haoyu Wu
    • , Lin Guo
    • , Yongqiang Chen
    • , You Chen
    • , Xuejia Li
    • , Hongling Wu
    • , Baojian Liao
    • , Wei He
    • , Hong Song
    • , Hongjie Yao
    • , Guangjin Pan
    • , Jiekai Chen
    •  & Duanqing Pei