Volume 17 Issue 6, June 2015

Volume 17 Issue 6

Liver pre-metastatic niche, resulting from fibronectin overexpression by hepatic stellate cells in response to TGFβ produced by von Kupffer cells activated by pancreatic tumour-derived exosomes.p816

News and Views

  • News & Views |

    Control of stem cell activity is essential for accurate regeneration. Pathogen- or chemical-induced intestinal damage is now shown to recruit haemocytes expressing bone morphogenetic protein signals that stimulate proliferation of intestinal stem cells and subsequently induce their quiescence, in conjunction with muscle-derived bone morphogenetic proteins. A temporal switch in expression of Type I receptors enables this two-phase response.

    • Lesley N. Weaver
    •  & Daniela Drummond-Barbosa
  • News & Views |

    Cancer cells are known to secrete exosomes with pro-metastatic effects. Pancreatic-cancer-derived exosomes are now shown to promote liver metastasis by eliciting pre-metastatic niche formation through a multi-step process. This involves uptake of exosome-derived factors by liver Kupffer cells and hepatic stellate cell activation to generate a fibrotic microenvironment with immune cell infiltrates that favours metastasis.

    • Yun Zhang
    •  & Xiao-Fan Wang
  • News & Views |

    A major controversy in the field of chromosome research has been whether condensin is required for achieving the highly compacted state of chromatin fibres in mitosis and meiosis. Through genetic experiments in mouse oocytes, condensin is now found to be indispensable for meiotic chromosome assembly by mediating chromosome compaction and disentanglement of sister chromatids and by conferring rigidity to chromosomes.

    • Kota Nagasaka
    •  & Toru Hirota

Articles

  • Article |

    Qin, Pei and colleagues report that autophagy is induced early during somatic cell reprogramming into induced pluripotent stem cells. mTORC1 and autophagy control reprogramming efficiency by modulating mitochondrial architecture and p62 levels.

    • Yasong Wu
    • , Yuan Li
    • , Hui Zhang
    • , Yinghua Huang
    • , Ping Zhao
    • , Yujia Tang
    • , Xiaohui Qiu
    • , Yue Ying
    • , Wen Li
    • , Su Ni
    • , Meng Zhang
    • , Longqi Liu
    • , Yan Xu
    • , Qiang Zhuang
    • , Zhiwei Luo
    • , Christina Benda
    • , Hong Song
    • , Baohua Liu
    • , Liangxue Lai
    • , Xingguo Liu
    • , Hung-Fat Tse
    • , Xichen Bao
    • , Wai-Yee Chan
    • , Miguel A. Esteban
    • , Baoming Qin
    •  & Duanqing Pei
  • Article |

    By inactivating condensin I or II before the first meiotic division in mouse oocytes, Nasmyth and colleagues demonstrate that condensin is needed for chromatin thread formation and chromosome rigidity.

    • Martin Houlard
    • , Jonathan Godwin
    • , Jean Metson
    • , Jibak Lee
    • , Tatsuya Hirano
    •  & Kim Nasmyth
  • Article |

    Gutkind and colleagues delineate a tumour suppressive signalling pathway involving the Gαs G protein and the PKA kinase, which inhibits pro-tumorigenic Yap and Shh signalling in epidermal stem cells.

    • Ramiro Iglesias-Bartolome
    • , Daniela Torres
    • , Romina Marone
    • , Xiaodong Feng
    • , Daniel Martin
    • , May Simaan
    • , Min Chen
    • , Lee S. Weinstein
    • , Susan S. Taylor
    • , Alfredo A. Molinolo
    •  & J. Silvio Gutkind
  • Article |

    Roose and colleagues report that the RasGRP1 and SOS1 guanine nucleotide exchange factors have opposing roles downstream of the EGFR, with RasGRP1 restricting SOS1-induced KRAS-ERK activation and suppressing intestinal tumorigenesis.

    • Philippe Depeille
    • , Linda M. Henricks
    • , Robert A. H. van de Ven
    • , Ed Lemmens
    • , Chih-Yang Wang
    • , Mary Matli
    • , Zena Werb
    • , Kevin M. Haigis
    • , David Donner
    • , Robert Warren
    •  & Jeroen P. Roose
  • Article |

    Lyden and colleagues report that pancreatic cancer-derived exosomes induce a pre-metastatic niche in the liver by promoting TGFβ secretion from Kupffer cells, leading to fibronectin production in hepatic stellate cells and macrophage recruitment.

    • Bruno Costa-Silva
    • , Nicole M. Aiello
    • , Allyson J. Ocean
    • , Swarnima Singh
    • , Haiying Zhang
    • , Basant Kumar Thakur
    • , Annette Becker
    • , Ayuko Hoshino
    • , Milica Tešić Mark
    • , Henrik Molina
    • , Jenny Xiang
    • , Tuo Zhang
    • , Till-Martin Theilen
    • , Guillermo García-Santos
    • , Caitlin Williams
    • , Yonathan Ararso
    • , Yujie Huang
    • , Gonçalo Rodrigues
    • , Tang-Long Shen
    • , Knut Jørgen Labori
    • , Inger Marie Bowitz Lothe
    • , Elin H. Kure
    • , Jonathan Hernandez
    • , Alexandre Doussot
    • , Saya H. Ebbesen
    • , Paul M. Grandgenett
    • , Michael A. Hollingsworth
    • , Maneesh Jain
    • , Kavita Mallya
    • , Surinder K. Batra
    • , William R. Jarnagin
    • , Robert E. Schwartz
    • , Irina Matei
    • , Héctor Peinado
    • , Ben Z. Stanger
    • , Jacqueline Bromberg
    •  & David Lyden

Corrigenda