Volume 17 Issue 2, February 2015

Volume 17 Issue 2

USP30 opposes parkin-mediated mitochondrial ubiquitylation.p160

News and Views

  • News & Views |

    Macrophages facilitate tumour progression, but it is unclear whether this capability is influenced by tumour-initiating cells. Glioblastoma stem cells are now shown to secrete periostin, a matrix protein that recruits protumoral macrophages and enhances glioblastoma progression in mice.

    • Mario Leonardo Squadrito
    •  & Michele De Palma
  • News & Views |

    The protrusion of cilia into extracellular space provides cells with sensors of localized environmental cues that include fluid flow, mechanical force and important growth factors such as Hedgehog. Live imaging has now captured the initial appearance of cilia during embryogenesis, and defined lineage-specific determinants that restrict extra-embryonal ciliogenesis.

    • Anna S. Nikonova
    •  & Erica A. Golemis