Volume 17 Issue 10, October 2015

Volume 17 Issue 10

Both tissue-level and local stresses underlie germband extension in the Drosophila embryo.p1247

Obituary

News and Views

  • News & Views |

    Cellular senescence is often accompanied by the production of secreted proteins that mediate the diverse effects of senescence on the tissue microenvironment. The mammalian target of rapamycin (mTOR), a master regulator of protein synthesis, is now shown to control the senescence-associated secretory phenotype by modulating gene transcription and mRNA translation and stabilization.

    • Kosuke Tomimatsu
    •  & Masashi Narita
  • News & Views |

    Decreases in endoplasmic reticulum calcium content are sensed by resident STIM proteins, which can activate plasma membrane Orai channels to facilitate Ca2+ entry. The role of STIMATE, a previously unknown component of the store-operated calcium entry complex, has now been identified and defined.

    • Robert Hooper
    •  & Jonathan Soboloff

Articles

  • Article |

    Using single-cell profiling of Nanog and Oct4 protein levels in mouse embryonic stem cells, Schroeder and colleagues show that differences in Nanog levels are not correlated with differences in expression of other pluripotency factors and cell fate.

    • Adam Filipczyk
    • , Carsten Marr
    • , Simon Hastreiter
    • , Justin Feigelman
    • , Michael Schwarzfischer
    • , Philipp S. Hoppe
    • , Dirk Loeffler
    • , Konstantinos D. Kokkaliaris
    • , Max Endele
    • , Bernhard Schauberger
    • , Oliver Hilsenbeck
    • , Stavroula Skylaki
    • , Jan Hasenauer
    • , Konstantinos Anastassiadis
    • , Fabian J. Theis
    •  & Timm Schroeder
  • Article |

    Zhang et al.report that in response to ROS, ATM regulates peroxisome homeostasis through the phosphorylation of PEX5, which is then ubiquitylated and can be recognized by p62 to specifically activate pexophagy.

    • Jiangwei Zhang
    • , Durga Nand Tripathi
    • , Ji Jing
    • , Angela Alexander
    • , Jinhee Kim
    • , Reid T. Powell
    • , Ruhee Dere
    • , Jacqueline Tait-Mulder
    • , Ji-Hoon Lee
    • , Tanya T. Paull
    • , Raj K. Pandita
    • , Vijaya K. Charaka
    • , Tej K. Pandita
    • , Michael B. Kastan
    •  & Cheryl Lyn Walker
  • Article |

    Chen et al. produced a quadruple knockout of all the known BH3-only proteins in order to characterize their pro-apoptotic functions. They establish that NOXA is a direct activator of BAX/BAK and not merely a sensitizer as previously suggested.

    • Hui-Chen Chen
    • , Masayuki Kanai
    • , Akane Inoue-Yamauchi
    • , Ho-Chou Tu
    • , Yafen Huang
    • , Decheng Ren
    • , Hyungjin Kim
    • , Shugaku Takeda
    • , Denis E. Reyna
    • , Po M. Chan
    • , Yogesh Tengarai Ganesan
    • , Chung-Ping Liao
    • , Evripidis Gavathiotis
    • , James J. Hsieh
    •  & Emily H. Cheng
  • Article |

    Malumbres and colleagues reveal that mitotic arrest is accompanied by reduced mitochondrial mass and oxidative respiration resulting in activation of AMPK and induction of glycolysis to promote cell survival.

    • Elena Doménech
    • , Carolina Maestre
    • , Lorena Esteban-Martínez
    • , David Partida
    • , Rosa Pascual
    • , Gonzalo Fernández-Miranda
    • , Esther Seco
    • , Ramón Campos-Olivas
    • , Manuel Pérez
    • , Diego Megias
    • , Katherine Allen
    • , Miguel López
    • , Asish K. Saha
    • , Guillermo Velasco
    • , Eduardo Rial
    • , Raúl Méndez
    • , Patricia Boya
    • , María Salazar-Roa
    •  & Marcos Malumbres
  • Article |

    SDH inactivation is associated with cancer susceptibility. Cardaci et al. report a metabolic vulnerability in SDH-deficient cells, by showing that they depend on pyruvate carboxylation for the production of aspartate, proliferation and tumour growth.

    • Simone Cardaci
    • , Liang Zheng
    • , Gillian MacKay
    • , Niels J. F. van den Broek
    • , Elaine D. MacKenzie
    • , Colin Nixon
    • , David Stevenson
    • , Sergey Tumanov
    • , Vinay Bulusu
    • , Jurre J. Kamphorst
    • , Alexei Vazquez
    • , Stewart Fleming
    • , Francesca Schiavi
    • , Gabriela Kalna
    • , Karen Blyth
    • , Douglas Strathdee
    •  & Eyal Gottlieb
  • Article |

    The TERT promoter is mutated in many cancers. Li et al. show that non-canonical NF-κB signalling and ETS1/2 transcription factors are jointly needed to activate the C250T mutant TERT promoter, leading to telomerase activity and glioblastoma growth.

    • Yinghui Li
    • , Qi-Ling Zhou
    • , Wenjie Sun
    • , Prashant Chandrasekharan
    • , Hui Shan Cheng
    • , Zhe Ying
    • , Manikandan Lakshmanan
    • , Anandhkumar Raju
    • , Daniel G. Tenen
    • , Shi-Yuan Cheng
    • , Kai-Hsiang Chuang
    • , Jun Li
    • , Shyam Prabhakar
    • , Mengfeng Li
    •  & Vinay Tergaonkar

Letters

  • Letter |

    Through a proteomic analysis of ER–PM junctions, Zhou and colleagues and Wang and colleagues discover that the transmembrane protein STIMATE is a positive regulator of STIM localization and function, thereby stimulating Ca2+ influx.

    • Ji Jing
    • , Lian He
    • , Aomin Sun
    • , Ariel Quintana
    • , Yuehe Ding
    • , Guolin Ma
    • , Peng Tan
    • , Xiaowen Liang
    • , Xiaolu Zheng
    • , Liangyi Chen
    • , Xiaodong Shi
    • , Shenyuan L. Zhang
    • , Ling Zhong
    • , Yun Huang
    • , Meng-Qiu Dong
    • , Cheryl L. Walker
    • , Patrick G. Hogan
    • , Youjun Wang
    •  & Yubin Zhou
  • Letter |

    Lu and colleagues report that the O-GlcNAcylated MIF cytokine binds the extracellular domain of EGFR and prevents EGF-induced EGFR activation. Conversely, EGFR activation leads to MMP13-mediated MIF degradation and EGFR-induced tumorigenesis

    • Yanhua Zheng
    • , Xinjian Li
    • , Xu Qian
    • , Yugang Wang
    • , Jong-Ho Lee
    • , Yan Xia
    • , David H. Hawke
    • , Gang Zhang
    • , Jianxin Lyu
    •  & Zhimin Lu

Resource

Corrigendum

Erratum

  • Erratum |

    • Nicolás Herranz
    • , Suchira Gallage
    • , Massimiliano Mellone
    • , Torsten Wuestefeld
    • , Sabrina Klotz
    • , Christopher J. Hanley
    • , Selina Raguz
    • , Juan Carlos Acosta
    • , Andrew J. Innes
    • , Ana Banito
    • , Athena Georgilis
    • , Alex Montoya
    • , Katharina Wolter
    • , Gopuraja Dharmalingam
    • , Peter Faull
    • , Thomas Carroll
    • , Juan Pedro Martínez-Barbera
    • , Pedro Cutillas
    • , Florian Reisinger
    • , Mathias Heikenwalder
    • , Richard A. Miller
    • , Dominic Withers
    • , Lars Zender
    • , Gareth J. Thomas
    •  & Jesús Gil