Deup1 mediates deuterosome formation and large-scale centriole amplification in multiciliated cells.p1434

Low gene expression noise ensures robust spindle assembly checkpoint signalling.p1328

miR-205 modulates neonatal hair follicle stem cells.p1153

Wnt signalling provides direction in planar cell polarity.p1045

A vesicle-based actin network positions the spindle asymmetrically in mouse oocytes.p937

Factors deposited in the basement membrane of mature endothelium induce quiescence of disseminated tumour cells, whereas neovascular tips deposit discrete factors that promote micrometastatic outgrowth.p807

TFEB promotes mobilization of lipid stores.p647

Bmi1-expressing cells ensure the maintenance and regeneration of keratinized cells in the murine lingual epithelium.p511

Polycomb Cbx proteins modulate self-renewal and differentiation in haematopoietic stem cells. [article p353]

α-catenin mutant cells lose adhesion and detach from each other in the follicular epithelium of the Drosophila egg chamber. [article p261]

Reactive oxygen species are required for tadpole tail regeneration. [letter p222]

Understanding how the deregulation of normal cell biological processes leads to malignant transformation and cancer progression is a major area of research. The Review in this issue is the first in a series of specially commissioned articles discussing current topics and recent advances in this field.