Volume 12 Issue 7, July 2010

Volume 12 Issue 7

Cell shape controls epidermal cell fate through actin-regulated SRF transcriptional activity.p711



News and Views

  • News & Views |

    Adherens junctions, the sites of cadherin-dependent cell–cell adhesion, are also important for dynamic tension sensing, force transduction and signalling. Different myosin motors contribute to adherens junction assembly and versatility in distinct ways.

    • Joshua C. Sandquist
    •  & William M. Bement
  • News & Views |

    Rab GTPases regulate the dynamics of transport carriers by participating in their translocation across the cytoplasm, and in their docking and fusion with acceptor compartments. An interaction between Golgi-associated Rab6 and myosin II has now been shown to regulate the fission of Rab6-positive carriers, illuminating a previously unappreciated role for Rab6 and the actomyosin system in carrier biogenesis.

    • Carmen Valente
    • , Roman Polishchuk
    •  & Maria Antonietta De Matteis
  • News & Views |

    Recognition of apoptotic cells by phagocytic cells in Caenorhabditis elegans has been something of a mystery. A secreted transthyretin-like protein, TTR-52, has been identified as a bridging molecule between apoptotic cells and CED-1 on the phagocytic cells that engulf them.

    • Rachael Rutkowski
    •  & Anton Gartner
  • News & Views |

    The importin-β-like transport receptors and RanGTP govern selective transport of proteins into the nucleus. It has now been shown that importin-β2 (alternatively called transportin1) also selectively targets the motor protein Kif17 to primary cilia. In analogy to the nucleus, RanGTP in the intraciliary compartment mediates dissociation of Kif17 from its transport receptor and thereby completes import.

    • Oliver J. Gruss
  • News & Views |

    Tumour suppressors of the Forkhead box O (FoxO) family are proposed to limit tumour growth through direct transcriptional regulation. Cytosolic FoxO1 can also suppress tumour growth by triggering autophagy and ultimately cell death in a transcription-independent manner.

    • René H. Medema
    •  & Marja Jäättelä

Research Highlights