Latest Research

  • Article |

    Nakamura et al. find that the master transcriptional regulator of lysosomal biogenesis and autophagy TFEB is activated following LC3 lipidation during lysosomal damage and show the importance of this mechanism during kidney injury.

    • Shuhei Nakamura
    • , Saki Shigeyama
    • , Satoshi Minami
    • , Takayuki Shima
    • , Shiori Akayama
    • , Tomoki Matsuda
    • , Alessandra Esposito
    • , Gennaro Napolitano
    • , Akiko Kuma
    • , Tomoko Namba-Hamano
    • , Jun Nakamura
    • , Kenichi Yamamoto
    • , Miwa Sasai
    • , Ayaka Tokumura
    • , Mika Miyamoto
    • , Yukako Oe
    • , Toshiharu Fujita
    • , Seigo Terawaki
    • , Atsushi Takahashi
    • , Maho Hamasaki
    • , Masahiro Yamamoto
    • , Yukinori Okada
    • , Masaaki Komatsu
    • , Takeharu Nagai
    • , Yoshitsugu Takabatake
    • , Haoxing Xu
    • , Yoshitaka Isaka
    • , Andrea Ballabio
    •  & Tamotsu Yoshimori
  • Letter |

    Xu et al. report that nuclear SIRT1 is recognized as an autophagy substrate during senescence and also observe ageing of the immune system.

    • Caiyue Xu
    • , Lu Wang
    • , Parinaz Fozouni
    • , Gry Evjen
    • , Vemika Chandra
    • , Jing Jiang
    • , Congcong Lu
    • , Michael Nicastri
    • , Corey Bretz
    • , Jeffrey D. Winkler
    • , Ravi Amaravadi
    • , Benjamin A. Garcia
    • , Peter D. Adams
    • , Melanie Ott
    • , Wei Tong
    • , Terje Johansen
    • , Zhixun Dou
    •  & Shelley L. Berger
  • Letter |

    Phase separation concentrates mitochondrial RNA granules. Here Rey et al., show that mitochondrial RNA granules (MRGs) behaviour is consistent with liquid–liquid phase separation (LLPS) and their fusion coincides with mitochondrial remodelling.

    • Timo Rey
    • , Sofia Zaganelli
    • , Emilie Cuillery
    • , Evangelia Vartholomaiou
    • , Marie Croisier
    • , Jean-Claude Martinou
    •  & Suliana Manley
  • Article |

    Lynch et al. demonstrate that inhibiting CDK8 and CDK19 kinases increases Mediator-driven recruitment of RNA Pol II to promoters and enhancers, therefore stabilizing the naive transcriptional program.

    • Cian J. Lynch
    • , Raquel Bernad
    • , Ana Martínez-Val
    • , Marta N. Shahbazi
    • , Sandrina Nóbrega-Pereira
    • , Isabel Calvo
    • , Carmen Blanco-Aparicio
    • , Carolina Tarantino
    • , Elena Garreta
    • , Laia Richart-Ginés
    • , Noelia Alcazar
    • , Osvaldo Graña-Castro
    • , Gonzalo Gómez-Lopez
    • , Irene Aksoy
    • , Maribel Muñoz-Martín
    • , Sonia Martinez
    • , Sagrario Ortega
    • , Susana Prieto
    • , Elisabeth Simboeck
    • , Alain Camasses
    • , Camille Stephan-Otto Attolini
    • , Agustin F. Fernandez
    • , Marta I. Sierra
    • , Mario F. Fraga
    • , Joaquin Pastor
    • , Daniel Fisher
    • , Nuria Montserrat
    • , Pierre Savatier
    • , Javier Muñoz
    • , Magdalena Zernicka-Goetz
    •  & Manuel Serrano
  • Article |

    Paris et al. show that after injury or influenza infection alveolar type II cells signal via a STAT3–BDNF axis that activates the TrkB receptor on mesenchymal niche cells and enhances alveolar repair.

    • Andrew J. Paris
    • , Katharina E. Hayer
    • , Joseph H. Oved
    • , Daphne C. Avgousti
    • , Sushila A. Toulmin
    • , Jarod A. Zepp
    • , William J. Zacharias
    • , Jeremy B. Katzen
    • , Maria C. Basil
    • , Madison M. Kremp
    • , April R. Slamowitz
    • , Sowmya Jayachandran
    • , Aravind Sivakumar
    • , Ning Dai
    • , Ping Wang
    • , David B. Frank
    • , Laurence C. Eisenlohr
    • , Edward Cantu III
    • , Michael F. Beers
    • , Matthew D. Weitzman
    • , Edward E. Morrisey
    •  & G. Scott Worthen
  • Letter |

    Xu, Liu, Pen, Zhang et al. demonstrate that the SEL1L–HRD1 complex, which is part of the ERAD protein quality control machinery, safeguards haematopoietic stem cell identity and niche location by ensuring the haematopoietic stem cell surface expression of MPL.

    • Longyong Xu
    • , Xia Liu
    • , Fanglue Peng
    • , Weijie Zhang
    • , Liting Zheng
    • , Yao Ding
    • , Tianpeng Gu
    • , Kaosheng Lv
    • , Jin Wang
    • , Laura Ortinau
    • , Tianyuan Hu
    • , Xiangguo Shi
    • , Guojun Shi
    • , Ge Shang
    • , Shengyi Sun
    • , Takao Iwawaki
    • , Yewei Ji
    • , Wei Li
    • , Jeffrey M. Rosen
    • , Xiang H.-F. Zhang
    • , Dongsu Park
    • , Stanley Adoro
    • , Andre Catic
    • , Wei Tong
    • , Ling Qi
    • , Daisuke Nakada
    •  & Xi Chen
  • Article |

    Lauria et al. show that SMN, the loss of which causes spinal muscular atrophy (SMA), preferentially positions ribosomes within the first five codons of SMA-related mRNAs and enhances their translation.

    • Fabio Lauria
    • , Paola Bernabò
    • , Toma Tebaldi
    • , Ewout Joan Nicolaas Groen
    • , Elena Perenthaler
    • , Federica Maniscalco
    • , Annalisa Rossi
    • , Deborah Donzel
    • , Massimiliano Clamer
    • , Marta Marchioretto
    • , Neža Omersa
    • , Julia Orri
    • , Mauro Dalla Serra
    • , Gregor Anderluh
    • , Alessandro Quattrone
    • , Alberto Inga
    • , Thomas Henry Gillingwater
    •  & Gabriella Viero
  • Article |

    Hou et al. show that following hypoxia PD-L1 translocates into the nucleus to enhance transcription of GSDMC, which is then cleaved and activated by caspase-8 to cause pyroptosis in cancer cells.

    • Junwei Hou
    • , Rongce Zhao
    • , Weiya Xia
    • , Chiung-Wen Chang
    • , Yun You
    • , Jung-Mao Hsu
    • , Lei Nie
    • , Yeh Chen
    • , Yu-Chuan Wang
    • , Chunxiao Liu
    • , Wei-Jan Wang
    • , Yun Wu
    • , Baozhen Ke
    • , Jennifer L. Hsu
    • , Kebin Huang
    • , Zu Ye
    • , Yi Yang
    • , Xianghou Xia
    • , Yintao Li
    • , Chia-Wei Li
    • , Bin Shao
    • , John A. Tainer
    •  & Mien-Chie Hung
  • Letter |

    Wei et al. show that clusters of unphosphorylated RNA polymerase II seed the nucleation of phase-separated condensates of TAF15, which further recruit RNA polymerase II to amplify transcriptional activation.

    • Ming-Tzo Wei
    • , Yi-Che Chang
    • , Shunsuke F. Shimobayashi
    • , Yongdae Shin
    • , Amy R. Strom
    •  & Clifford P. Brangwynne
  • Article |

    Daneshvar et al. show that BRD3 and the lncRNA DIGIT form phase-separated condensates at genomic regions with H3K18ac to co-regulate the transcription of genes that drive endoderm differentiation.

    • Kaveh Daneshvar
    • , M. Behfar Ardehali
    • , Isaac A. Klein
    • , Fu-Kai Hsieh
    • , Arcadia J. Kratkiewicz
    • , Amin Mahpour
    • , Sabrina O. L. Cancelliere
    • , Chan Zhou
    • , Brett M. Cook
    • , Wenyang Li
    • , Joshua V. Pondick
    • , Sweta K. Gupta
    • , Sean P. Moran
    • , Richard A. Young
    • , Robert E. Kingston
    •  & Alan C. Mullen
  • Technical Report |

    Moghadam et al. developed a CRISPR transcriptional repressor to silence MyD88 expression in vivo to modulate immune response against AAV gene therapy and septicaemia.

    • Farzaneh Moghadam
    • , Ryan LeGraw
    • , Jeremy J. Velazquez
    • , Nan Cher Yeo
    • , Chenxi Xu
    • , Jin Park
    • , Alejandro Chavez
    • , Mo R. Ebrahimkhani
    •  & Samira Kiani
  • Letter |

    Two complementary studies from the laboratories of Riegman et al. and Katikaneni et al., respectively, identify a key role for controlled wave-like propagation of lipid peroxide signalling during wound detection in vivo and in ferroptotic cell death.

    • Michelle Riegman
    • , Liran Sagie
    • , Chen Galed
    • , Tom Levin
    • , Noah Steinberg
    • , Scott J. Dixon
    • , Ulrich Wiesner
    • , Michelle S. Bradbury
    • , Philipp Niethammer
    • , Assaf Zaritsky
    •  & Michael Overholtzer
  • Article |

    Here Miceli et al. show that shear stress on primary cilia induces mitochondrial biogenesis and metabolic reprogramming in kidney epithelial cells through lipophagy stimulation.

    • Caterina Miceli
    • , Federica Roccio
    • , Lucille Penalva-Mousset
    • , Martine Burtin
    • , Christine Leroy
    • , Ivan Nemazanyy
    • , Nicolas Kuperwasser
    • , Marco Pontoglio
    • , Gérard Friedlander
    • , Etienne Morel
    • , Fabiola Terzi
    • , Patrice Codogno
    •  & Nicolas Dupont
  • Letter |

    Two complementary studies from the laboratories of Riegman et al. and Katikaneni et al., respectively, identify a key role for controlled wave-like propagation of lipid peroxide signalling during wound detection in vivo, and in ferroptotic cell death.

    • Anushka Katikaneni
    • , Mark Jelcic
    • , Gary F. Gerlach
    • , Yanan Ma
    • , Michael Overholtzer
    •  & Philipp Niethammer
  • Publisher Correction |

    • Huilin Huang
    • , Hengyou Weng
    • , Wenju Sun
    • , Xi Qin
    • , Hailing Shi
    • , Huizhe Wu
    • , Boxuan Simen Zhao
    • , Ana Mesquita
    • , Chang Liu
    • , Celvie L. Yuan
    • , Yueh-Chiang Hu
    • , Stefan Hüttelmaier
    • , Jennifer R. Skibbe
    • , Rui Su
    • , Xiaolan Deng
    • , Lei Dong
    • , Miao Sun
    • , Chenying Li
    • , Sigrid Nachtergaele
    • , Yungui Wang
    • , Chao Hu
    • , Kyle Ferchen
    • , Kenneth D. Greis
    • , Xi Jiang
    • , Minjie Wei
    • , Lianghu Qu
    • , Jun-Lin Guan
    • , Chuan He
    • , Jianhua Yang
    •  & Jianjun Chen
  • Article |

    Moro et al. show that hypermethylation-induced silencing of the ubiquitin ligase FBXL7 rescues c-SRC from ubiquitin-mediated degradation and enhances epithelial-to-mesenchymal transition and metastasis.

    • Loredana Moro
    • , Daniele Simoneschi
    • , Emma Kurz
    • , Arnaldo A. Arbini
    • , Shaowen Jang
    • , Nicoletta Guaragnella
    • , Sergio Giannattasio
    • , Wei Wang
    • , Yu-An Chen
    • , Geoffrey Pires
    • , Andrew Dang
    • , Elizabeth Hernandez
    • , Payal Kapur
    • , Ankita Mishra
    • , Aristotelis Tsirigos
    • , George Miller
    • , Jer-Tsong Hsieh
    •  & Michele Pagano
  • Article |

    Ilina et al. investigate the balance between cell adhesion and matrix density on patterns of collective breast cancer cell invasion using three-dimensional models of the extracellular matrix, in vivo imaging and in silico modelling

    • Olga Ilina
    • , Pavlo G. Gritsenko
    • , Simon Syga
    • , Jürgen Lippoldt
    • , Caterina A. M. La Porta
    • , Oleksandr Chepizhko
    • , Steffen Grosser
    • , Manon Vullings
    • , Gert-Jan Bakker
    • , Jörn Starruß
    • , Peter Bult
    • , Stefano Zapperi
    • , Josef A. Käs
    • , Andreas Deutsch
    •  & Peter Friedl
  • Article |

    Gao et al. uncover p300-induced acetylation and HDAC2-mediated deacetylation of PD-L1, which modulate its nuclear translocation to affect the expression of immune genes and the efficacy of anti-PD-1 therapy.

    • Yang Gao
    • , Naoe Taira Nihira
    • , Xia Bu
    • , Chen Chu
    • , Jinfang Zhang
    • , Aleksandra Kolodziejczyk
    • , Yizeng Fan
    • , Ngai Ting Chan
    • , Leina Ma
    • , Jing Liu
    • , Dong Wang
    • , Xiaoming Dai
    • , Huadong Liu
    • , Masaya Ono
    • , Akira Nakanishi
    • , Hiroyuki Inuzuka
    • , Brian J. North
    • , Yu-Han Huang
    • , Samanta Sharma
    • , Yan Geng
    • , Wei Xu
    • , X. Shirley Liu
    • , Lei Li
    • , Yoshio Miki
    • , Piotr Sicinski
    • , Gordon J. Freeman
    •  & Wenyi Wei
  • Article |

    Nowosad et al. show that during amino acid starvation, the cell-cycle inhibitor p27 binds LAMTOR1 on lysosomes to inhibit mTOR and promote autophagy, linking cell division and cell growth machineries.

    • Ada Nowosad
    • , Pauline Jeannot
    • , Caroline Callot
    • , Justine Creff
    • , Renaud Thierry Perchey
    • , Carine Joffre
    • , Patrice Codogno
    • , Stephane Manenti
    •  & Arnaud Besson
  • Letter |

    Liu et al. characterize a mechanism of UFL1-mediated UFMylation of p53 at multiple lysine residues and show how this dampens MDM2-induced ubiquitination of p53 to enhance its stability and tumour-suppressive function.

    • Jiang Liu
    • , Di Guan
    • , Maogong Dong
    • , Jingjing Yang
    • , Haibin Wei
    • , Qian Liang
    • , Lizhi Song
    • , Lu Xu
    • , Junjie Bai
    • , Cui Liu
    • , Jian Mao
    • , Qian Zhang
    • , Junzhi Zhou
    • , Xiaoying Wu
    • , Miao Wang
    •  & Yu-Sheng Cong
  • Article |

    Kumar et al. show that mammalian Atg8 proteins along with IRGM regulate the lysosomal system via mTOR and TFEB, respectively, in the response to pathogens.

    • Suresh Kumar
    • , Ashish Jain
    • , Seong Won Choi
    • , Gustavo Peixoto Duarte da Silva
    • , Lee Allers
    • , Michal H. Mudd
    • , Ryan Scott Peters
    • , Jan Haug Anonsen
    • , Tor-Erik Rusten
    • , Michael Lazarou
    •  & Vojo Deretic
  • Article |

    Profiling phenotype switching in melanoma. Wouters et al. perform large-scale gene expression analysis in patient samples and identify transcriptional networks that modulate the intermediate cell state and ultimate mesenchymal switching in melanoma.

    • Jasper Wouters
    • , Zeynep Kalender-Atak
    • , Liesbeth Minnoye
    • , Katina I. Spanier
    • , Maxime De Waegeneer
    • , Carmen Bravo González-Blas
    • , David Mauduit
    • , Kristofer Davie
    • , Gert Hulselmans
    • , Ahmad Najem
    • , Michael Dewaele
    • , Dennis Pedri
    • , Florian Rambow
    • , Samira Makhzami
    • , Valerie Christiaens
    • , Frederik Ceyssens
    • , Ghanem Ghanem
    • , Jean-Christophe Marine
    • , Suresh Poovathingal
    •  & Stein Aerts
  • Article |

    Dhamija et al. profile 3,412 nonstop mutations from 62 tumour entities and as proof of concept demonstrate that six such mutations cause degradation and loss of the tumour suppressor SMAD4.

    • Sonam Dhamija
    • , Chul Min Yang
    • , Jeanette Seiler
    • , Ksenia Myacheva
    • , Maiwen Caudron-Herger
    • , Angela Wieland
    • , Mahmoud Abdelkarim
    • , Yogita Sharma
    • , Marisa Riester
    • , Matthias Groß
    • , Jochen Maurer
    •  & Sven Diederichs
  • Letter |

    Sato et al. demonstrate that IRF2, which negatively regulates interferon signalling, safeguards intestinal stem cells against non-infectious, sterile interferon stress by limiting their differentiation into secretory lineages.

    • Taku Sato
    • , Shun Ishikawa
    • , Jumpei Asano
    • , Hirona Yamamoto
    • , Masayuki Fujii
    • , Toshiro Sato
    • , Kouhei Yamamoto
    • , Keisuke Kitagaki
    • , Takumi Akashi
    • , Ryuichi Okamoto
    •  & Toshiaki Ohteki
  • Article |

    After lung injury, Kobayashi, Tata et al. find an intermediate cell state during the transition of alveolar type-2 into type-1 cells that is associated with senescence, controlled by TP53 and persists in fibrosis.

    • Yoshihiko Kobayashi
    • , Aleksandra Tata
    • , Arvind Konkimalla
    • , Hiroaki Katsura
    • , Rebecca F. Lee
    • , Jianhong Ou
    • , Nicholas E. Banovich
    • , Jonathan A. Kropski
    •  & Purushothama Rao Tata
  • Article |

    Vietri et al. show that the micronucleus fails to restrain ESCRT-III spreading due to its small size, resulting in aberrant accumulation of ESCRT-III to drive micronuclear collapse and DNA fragmentation.

    • Marina Vietri
    • , Sebastian W. Schultz
    • , Aurélie Bellanger
    • , Carl M. Jones
    • , Louise I. Petersen
    • , Camilla Raiborg
    • , Ellen Skarpen
    • , Christeen Ramane J. Pedurupillay
    • , Ingrid Kjos
    • , Eline Kip
    • , Romy Timmer
    • , Ashish Jain
    • , Philippe Collas
    • , Roland L. Knorr
    • , Sushma N. Grellscheid
    • , Halim Kusumaatmaja
    • , Andreas Brech
    • , Francesca Micci
    • , Harald Stenmark
    •  & Coen Campsteijn
  • Article |

    Burton et al. show that H3K9me3 deposition catalysed by SUV39H2 and regulated by pericentromeric RNAs in the mouse paternal pronucleus does not suppress gene expression, but bookmarks promoters for compaction.

    • Adam Burton
    • , Vincent Brochard
    • , Carmen Galan
    • , Elias R. Ruiz-Morales
    • , Quirze Rovira
    • , Diego Rodriguez-Terrones
    • , Kai Kruse
    • , Stéphanie Le Gras
    • , Vishnu S. Udayakumar
    • , Hang Gyeong Chin
    • , André Eid
    • , Xiaoyu Liu
    • , Chenfei Wang
    • , Shaorong Gao
    • , Sriharsa Pradhan
    • , Juan M. Vaquerizas
    • , Nathalie Beaujean
    • , Thomas Jenuwein
    •  & Maria-Elena Torres-Padilla
  • Article |

    Cao et al. show that SPIN90 enhances formation of Arp2/3-mediated unbranched filaments and promotes a formin-based cortex by recruiting mDia1 or forming a ternary SPIN90–Arp2/3–mDia1 complex.

    • Luyan Cao
    • , Amina Yonis
    • , Malti Vaghela
    • , Elias H. Barriga
    • , Priyamvada Chugh
    • , Matthew B. Smith
    • , Julien Maufront
    • , Geneviève Lavoie
    • , Antoine Méant
    • , Emma Ferber
    • , Miia Bovellan
    • , Art Alberts
    • , Aurélie Bertin
    • , Roberto Mayor
    • , Ewa K. Paluch
    • , Philippe P. Roux
    • , Antoine Jégou
    • , Guillaume Romet-Lemonne
    •  & Guillaume Charras
  • Letter |

    Hsu et al. find that the protein kinase Akt acts as a co-adaptor in the clathrin coat complex and is needed in conjunction with ACAP1 to bind to cargo proteins to promote their recycling.

    • Jia-Wei Hsu
    • , Ming Bai
    • , Kunhua Li
    • , Jia-Shu Yang
    • , Nam Chu
    • , Philip A. Cole
    • , Michael J. Eck
    • , Jian Li
    •  & Victor W. Hsu
  • Article |

    Sheikh et al. show that deficiency in the lysine acetyltransferase MOF causes aberrant accumulation of fatty acids in neural cells, which in turn triggers inflammation in nearby pericytes, resulting in brain haemorrhaging.

    • Bilal N. Sheikh
    • , Sukanya Guhathakurta
    • , Tsz Hong Tsang
    • , Marius Schwabenland
    • , Gina Renschler
    • , Benjamin Herquel
    • , Vivek Bhardwaj
    • , Herbert Holz
    • , Thomas Stehle
    • , Olga Bondareva
    • , Nadim Aizarani
    • , Omar Mossad
    • , Oliver Kretz
    • , Wilfried Reichardt
    • , Aindrila Chatterjee
    • , Laura J. Braun
    • , Julien Thevenon
    • , Herve Sartelet
    • , Thomas Blank
    • , Dominic Grün
    • , Dominik von Elverfeldt
    • , Tobias B. Huber
    • , Dietmar Vestweber
    • , Sergiy Avilov
    • , Marco Prinz
    • , Joerg M. Buescher
    •  & Asifa Akhtar
  • Article |

    Roider et al. combine scRNA-seq and transcriptome-informed flow cytometry, and uncover transcriptionally different malignant subclones with distinct drug responses and T-cell profiles in B-cell non-Hodgkin lymphoma.

    • Tobias Roider
    • , Julian Seufert
    • , Alexey Uvarovskii
    • , Felix Frauhammer
    • , Marie Bordas
    • , Nima Abedpour
    • , Marta Stolarczyk
    • , Jan-Philipp Mallm
    • , Sophie A. Herbst
    • , Peter-Martin Bruch
    • , Hyatt Balke-Want
    • , Michael Hundemer
    • , Karsten Rippe
    • , Benjamin Goeppert
    • , Martina Seiffert
    • , Benedikt Brors
    • , Gunhild Mechtersheimer
    • , Thorsten Zenz
    • , Martin Peifer
    • , Björn Chapuy
    • , Matthias Schlesner
    • , Carsten Müller-Tidow
    • , Stefan Fröhling
    • , Wolfgang Huber
    • , Simon Anders
    •  & Sascha Dietrich
  • Article |

    Bischof and colleagues report that AP-1 bookmarks prospective senescence enhancers for future activation to achieve a timely execution of the senescence programme.

    • Ricardo Iván Martínez-Zamudio
    • , Pierre-François Roux
    • , José Américo N.L.F. de Freitas
    • , Lucas Robinson
    • , Gregory Doré
    • , Bin Sun
    • , Dimitri Belenki
    • , Maja Milanovic
    • , Utz Herbig
    • , Clemens A. Schmitt
    • , Jesús Gil
    •  & Oliver Bischof
  • Publisher Correction |

    • Sarah Theresa Boyle
    • , Valentina Poltavets
    • , Jasreen Kular
    • , Natasha Theresa Pyne
    • , Jarrod John Sandow
    • , Alexander Charles Lewis
    • , Kendelle Joan Murphy
    • , Natasha Kolesnikoff
    • , Paul Andre Bartholomew Moretti
    • , Melinda Nay Tea
    • , Vinay Tergaonkar
    • , Paul Timpson
    • , Stuart Maxwell Pitson
    • , Andrew Ian Webb
    • , Robert John Whitfield
    • , Angel Francisco Lopez
    • , Marina Kochetkova
    •  & Michael Susithiran Samuel
  • Letter |

    Tumour fibroblasts influence oncolytic viral therapy. Arwert et al. show that transcytosis of cancer cells into fibroblasts activates STING and IRF3 to upregulate interferon-β1, eliciting a transcriptional program to reduce the effectiveness of oncolytic viral therapy.

    • Esther N. Arwert
    • , Emma L. Milford
    • , Antonio Rullan
    • , Stefanie Derzsi
    • , Steven Hooper
    • , Takuya Kato
    • , David Mansfield
    • , Alan Melcher
    • , Kevin J. Harrington
    •  & Erik Sahai
  • Article |

    Exon–intron-fused RAB22A regulates metastasis of osteosarcoma. Liao et al. show that protein products resulting from chromosomal translocations involving RAB22A mediate release of GTP-bound RhoA, induce its activation and promote lung metastasis of osteosarcoma.

    • Dan Liao
    • , Li Zhong
    • , Junqiang Yin
    • , Cuiling Zeng
    • , Xin Wang
    • , Xingchuan Huang
    • , Jinna Chen
    • , Hong Zhang
    • , Ruhua Zhang
    • , Xin-Yuan Guan
    • , Xintao Shuai
    • , Jianhua Sui
    • , Song Gao
    • , Wuguo Deng
    • , Yi-Xin Zeng
    • , Jing-Nan Shen
    • , Jian Chen
    •  & Tiebang Kang
  • Article |

    Baksh et al. show that oncogenic epidermal stem cells require extracellular serine to initiate squamous cell carcinoma via altering dioxygenases that remove H3K27me3.

    • Sanjeethan C. Baksh
    • , Pavlina K. Todorova
    • , Shiri Gur-Cohen
    • , Brian Hurwitz
    • , Yejing Ge
    • , Jesse S. S. Novak
    • , Matthew T. Tierney
    • , June dela Cruz-Racelis
    • , Elaine Fuchs
    •  & Lydia W. S. Finley
  • Article |

    Zhang et al. show that dynamin forms a helical structure with actin and, upon disruption, enhances branched actin polymerization, constituting a dynamic cycle to regulate actin cytoskeleton mechanical strength.

    • Ruihui Zhang
    • , Donghoon M. Lee
    • , John R. Jimah
    • , Nathalie Gerassimov
    • , Changsong Yang
    • , Sangjoon Kim
    • , Delgermaa Luvsanjav
    • , Jonathan Winkelman
    • , Marcel Mettlen
    • , Michael E. Abrams
    • , Raghav Kalia
    • , Peter Keene
    • , Pratima Pandey
    • , Benjamin Ravaux
    • , Ji Hoon Kim
    • , Jonathon A. Ditlev
    • , Guofeng Zhang
    • , Michael K. Rosen
    • , Adam Frost
    • , Neal M. Alto
    • , Margaret Gardel
    • , Sandra L. Schmid
    • , Tatyana M. Svitkina
    • , Jenny E. Hinshaw
    •  & Elizabeth H. Chen
  • Article |

    Boyle et al. show that ROCK upregulates PERK signalling in epithelia of breast cancer, thereby enhancing recruitment and function of cancer-associated fibroblasts through CRELD2 to promote tumourigenesis.

    • Sarah Theresa Boyle
    • , Valentina Poltavets
    • , Jasreen Kular
    • , Natasha Theresa Pyne
    • , Jarrod John Sandow
    • , Alexander Charles Lewis
    • , Kendelle Joan Murphy
    • , Natasha Kolesnikoff
    • , Paul Andre Bartholomew Moretti
    • , Melinda Nay Tea
    • , Vinay Tergaonkar
    • , Paul Timpson
    • , Stuart Maxwell Pitson
    • , Andrew Ian Webb
    • , Robert John Whitfield
    • , Angel Francisco Lopez
    • , Marina Kochetkova
    •  & Michael Susithiran Samuel