The endosomal sorting complex required for transport (ESCRT)-III is critical for membrane abscission; however, the mechanism underlying ESCRT-III-mediated membrane constriction remains elusive. A study of the dynamic assembly and disassembly of the ESCRT-III machinery in vitro and in vivo now suggests that the turnover of the observed spiralling filaments is critical for membrane abscission during cytokinesis.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Henne, W. M., Buchkovich, N. J. & Emr, S. D. Dev. Cell 21, 77–91 (2011).
Alonso, Y. A. M., Migliano, S. M. & Teis, D. FEBS J. 283, 3288–3302 (2016).
Schöneberg, J., Lee, I. H., Iwasa, J. H. & Hurley, J. H. Nat. Rev. Mol. Cell Biol. 18, 5–17 (2017).
Hurley, J. H. EMBO J. 34, 2398–2407 (2015).
Chiaruttini, N. et al. Cell 163, 866–879 (2015).
Mierzwa, B. E. et al. Nat. Cell Biol. 19, 787–798 (2017).
Lindås, A. C., Karlsson, E. A., Lindgren, M. T., Ettema, T. J. & Bernander, R. Proc. Natl Acad. Sci. USA 105, 18942–18946 (2008).
Szwedziak, P., Wang, Q., Bharat, T. A., Tsim, M. & Löwe, J. Elife 3, e04601 (2014).
Mingorance, J. et al. J. Biol. Chem. 280, 20909–20914 (2005).
Arumugam, S., Petrášek, Z. & Schwille, P. Proc. Natl Acad. Sci. USA 111, E1192–E1200 (2014).
Loose, M. & Mitchison, T. J. Nat. Cell Biol. 16, 38–46 (2014).
Ramirez, D. et al. Preprint at https://doi.org/10.1101/079533 (2016).
Bisson-Filho, A. W. et al. Science 355, 739–743 (2017).
Lan, G., Daniels, B. R., Dobrowsky, T. M., Wirtz, D. & Sun, S. X. Proc. Natl Acad. Sci. USA 106, 121–126 (2009).
Lansky, Z. et al. Cell 160, 1159–1168 (2015).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Franquelim, H., Schwille, P. Revolving around constriction by ESCRT-III. Nat Cell Biol 19, 754–756 (2017). https://doi.org/10.1038/ncb3569
Published:
Issue Date:
DOI: https://doi.org/10.1038/ncb3569