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Inter-organ regulation of haem homeostasis

Nature Cell Biology volume 19, pages 756–758 (2017)Cite this article

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Haem is an iron-containing cofactor required for life. Many cellular processes rely on haem and failure to maintain iron homeostasis results in numerous pathological conditions. A study now identifies a Caenorhabditis elegans inter-organ signalling pathway in which secreted intestinal HRG-7 and neuronally secreted BMP signals coordinate animal haem homeostasis.

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Figure 1: New players in the proposed C. elegans haem homeostasis pathway.

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  1. Department of Pathology, University of Washington, 1959 NE Pacific Street, Seattle, 98195, Washington, USA

    Jason N. Pitt & Matt Kaeberlein

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  1. Jason N. Pitt
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  2. Matt Kaeberlein
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Correspondence to Matt Kaeberlein.

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The authors declare no competing financial interests.

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Pitt, J., Kaeberlein, M. Inter-organ regulation of haem homeostasis. Nat Cell Biol 19, 756–758 (2017). https://doi.org/10.1038/ncb3568

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