The skin forms a protective, water-impermeable barrier consisting of heavily crosslinked epithelial cells. However, the specific role of stem cells in sustaining this barrier remains a contentious issue. A detailed analysis of the interfollicular epidermis now proposes a model for how a composite of cells with different properties are involved in its maintenance.
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Andersen, M., Jensen, K. Stem cell heterogeneity revealed. Nat Cell Biol 18, 587–589 (2016). https://doi.org/10.1038/ncb3368
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DOI: https://doi.org/10.1038/ncb3368