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    Inaugurated in 2018, the Human BioMolecular Atlas Program (HuBMAP) endeavours to construct comprehensive spatial maps that feature a range of biomolecules such as RNA, proteins, and metabolites in human organs at single-cell resolution.

    Image: Heidi Schlehlein

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    Stem cell models of development, regeneration, and disease are quickly advancing. New technologies and concepts are continuously combined with existing knowledge to create more realistic systems to improve our understanding of these intricate processes. In this collection, we highlight papers published in 2022-2023 across Nature Portfolio journals on topics including embryonic development and stem cells, reproductive biology, synthetic tissues and embryo models, clinical and translational research and tissue stem cells.

    Image: Jean-Baptiste Sibarita, Virgile Viasnoff, and Anne Beghin

  • Collection |

    Cancer is a leading cause of death, accounting for nearly one in six deaths worldwide. Many cancers can be cured, especially if detected early and treated effectively.

    Image: Kateryna Lon/ Science Photo Library/ Getty Images

  • Collection |

    Selected, recent articles from across the Nature Portfolio that document the recent progress in understanding the biology of EV-mediated cell–cell communication and advances in clinical translation of EVs.

    Image: Vicky Summersby

  • Collection |

    One of the fundamental biological processes in life is the cell cycle leading from DNA replication to cell division. While it has been studied for decades and our knowledge has matured, sophisticated experimental approaches have rejuvenated the field. In addition, cell cycle regulators have emerged as cancer therapy targets. This collection showcases ground-breaking cell cycle papers and reviews, ranging from basic discoveries to clinical applications.

    Image: Nicolas Plachta, NCB (2022)

  • Collection |

    Research interest is growing in profiling noncoding RNAs and understanding their biological functions in health and disease contexts.

    Image: Jeren (France) / Getty Images

  • Collection |

    This Collection showcases recent articles from Nature Cell Biology, Nature Metabolism and Nature Reviews Molecular Cell Biology covering cellular to systemic metabolic regulation. This selection accompanies the Nature Conference “Metabolic Communication Across Biological Scales” and provides a resource about current trends and directions in this field.

    Image: V. Summersby

  • Collection |

    Recent technological progress has facilitated the study of how embryos develop, how embryonic cells transition between different states, how adult stem cells are maintained and differentiate, at unprecedented resolution.

    Image: Deepti L Kumar and Tony DeFalco

  • Collection |

    This collection of primary research articles, reviews and protocols focuses on an emerging topic of mechanobiology, highlighting the broad involvement of mechanical forces in different biological contexts, their roles in development, physiology and disease, and how these forces are sensed and transduced to produce biologically-relevant responses. The collection also showcases new technical approaches to modulate mechanobiology, which in the future could be used to control cell fate and behaviour for therapeutic benefits.

    Image: Vicky Summersby

  • Collection |

    The 2020 Nobel Prize in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer Doudna for their pioneering work in gene-editing.

    Image: Springer Nature/The Nobel Foundation/Imagesource

  • Collection |

    New technologies to study stem cells have increased our knowledge about their physiological roles and contributions to development, ageing, regeneration and disease. This collection showcases research articles, reviews and protocols from across the Nature journals to highlight the striking advances made in basic and translational stem cell research.

    Image: Benedetta Artegiani and Delilah Hendriks, Hubrecht Institute, Utrecht, The Netherlands.