Review Articles

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  • Ferroptosis is a form of cell death that is characterized by morphological abnormalities of mitochondria and the overwhelming peroxidation of phospholipids. Certain tumours are susceptible to ferroptosis, which could be exploited to treat cancers.

    • Toshitaka Nakamura
    • Marcus Conrad
    Review Article
  • Granath-Panelo and Kajimura review emerging evidence of mitochondrial heterogeneity in different contexts and discuss how mitochondrial malleability contributes to cell fate determination and tissue remodelling.

    • Melia Granath-Panelo
    • Shingo Kajimura
    Review Article
  • Metastatic colonization involves cancer-cell-intrinsic mechanisms and microenvironmental interactions, and a better understanding of the factors that influence the final, post-extravasation phases is crucial for therapeutically targeting metatstasis.

    • Arthur W. Lambert
    • Yun Zhang
    • Robert A. Weinberg
    Review Article
  • Mathiowetz and Olzmann review our current understanding of the mechanisms of lipid droplet biogenesis and turnover, the transfer of lipids and metabolites at membrane contact sites, and the role of lipid droplets in regulating fatty acid flux in lipotoxicity and cell death.

    • Alyssa J. Mathiowetz
    • James A. Olzmann
    Review Article
  • In this Review, Dai, Stockwell, Kroemer, Tang and colleagues offer a comprehensive discussion of the molecular regulation of ferroptosis and highlight how this may be potentially leveraged for therapeutic benefit for disease treatment.

    • Enyong Dai
    • Xin Chen
    • Daolin Tang
    Review Article
  • The mechanisms controlling lysosome abundance in cells and how changes in lysosome pool size impact physiological and pathophysiological processes are discussed.

    • Anders P. Mutvei
    • Michal J. Nagiec
    • John Blenis
    Review Article
  • In this Review, Andrew Modzelewski, Johnny Gan Chong, Ting Wang and Lin He discuss how sequences introduced by transposon activities provide raw material for genome innovation and document the distinct evolutionary path of each species.

    • Andrew J. Modzelewski
    • Johnny Gan Chong
    • Lin He
    Review Article
  • In this Review, Polyak and colleagues discuss cellular and microenvironmental mechanisms that contribute to intratumour heterogeneity and how this affects immune escape and tumour progression.

    • Zheqi Li
    • Marco Seehawer
    • Kornelia Polyak
    Review Article
  • Le et al. review various technologies for imaging RNAs in fixed and live cells and the biological insights gained from these technologies.

    • Phuong Le
    • Noorsher Ahmed
    • Gene W. Yeo
    Review Article
  • Rossiello et al. review the contributions of telomere shortening and/or dysfunction to ageing and a broad spectrum of age-associated human diseases.

    • Francesca Rossiello
    • Diana Jurk
    • Fabrizio d’Adda di Fagagna
    Review Article
  • In this Review, Hurley and colleagues cover the most recent discoveries and the emerging molecular understanding of the mechanisms of autophagosome formation.

    • Chunmei Chang
    • Liv E. Jensen
    • James H. Hurley
    Review Article
  • Legube and Marnef review the association between R-loops and DNA repair. They discuss how R-loops are formed near DNA double-strand breaks (DSBs) and how R-loops affect transcription near DSBs and DSB repair processes.

    • Aline Marnef
    • Gaëlle Legube
    Review Article
  • Karoutas and Akhtar review the roles of the nuclear lamina in chromatin-related functions, including transcription, epigenetic regulation and chromatin architecture, and their abnormalities in diseases and ageing.

    • Adam Karoutas
    • Asifa Akhtar
    Review Article
  • Qi and colleagues review CRISPR-based epigenome engineering technologies to modulate histone and DNA modifications and to perturb DNA and RNA regulatory elements and chromatin organization.

    • Muneaki Nakamura
    • Yuchen Gao
    • Lei S. Qi
    Review Article
  • Groth and colleagues discuss recent advances in chromatin replication and maintenance across mitotic division, with emphasis on replication-coupled chromatin assembly and chromatin maturation post-replication.

    • Kathleen R. Stewart-Morgan
    • Nataliya Petryk
    • Anja Groth
    Review Article
  • Harnessing DNA repair pathways in genome editing In this Review, Yeh, Richardson and Corn discuss the DNA repair pathways that underlie genome editing and recent improvements and strategies to yield desired genomic alterations in cells and organisms.

    • Charles D. Yeh
    • Christopher D. Richardson
    • Jacob E. Corn
    Review Article