Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Xie et al. show that efficient miRNA biogenesis in Arabidopsis requires the assembly of pre-miRNA processing bodies mediated by SERRATE phase separation.
Phase separation concentrates mitochondrial RNA granules. Here Rey et al., show that mitochondrial RNA granules (MRGs) behaviour is consistent with liquid–liquid phase separation (LLPS) and their fusion coincides with mitochondrial remodelling.
Xu, Liu, Pen, Zhang et al. demonstrate that the SEL1L–HRD1 complex, which is part of the ERAD protein quality control machinery, safeguards haematopoietic stem cell identity and niche location by ensuring the haematopoietic stem cell surface expression of MPL.
Wei et al. show that clusters of unphosphorylated RNA polymerase II seed the nucleation of phase-separated condensates of TAF15, which further recruit RNA polymerase II to amplify transcriptional activation.
Two complementary studies from the laboratories of Riegman et al. and Katikaneni et al., respectively, identify a key role for controlled wave-like propagation of lipid peroxide signalling during wound detection in vivo and in ferroptotic cell death.
Two complementary studies from the laboratories of Riegman et al. and Katikaneni et al., respectively, identify a key role for controlled wave-like propagation of lipid peroxide signalling during wound detection in vivo, and in ferroptotic cell death.
Liu et al. characterize a mechanism of UFL1-mediated UFMylation of p53 at multiple lysine residues and show how this dampens MDM2-induced ubiquitination of p53 to enhance its stability and tumour-suppressive function.
Sato et al. demonstrate that IRF2, which negatively regulates interferon signalling, safeguards intestinal stem cells against non-infectious, sterile interferon stress by limiting their differentiation into secretory lineages.
Hsu et al. find that the protein kinase Akt acts as a co-adaptor in the clathrin coat complex and is needed in conjunction with ACAP1 to bind to cargo proteins to promote their recycling.
Tumour fibroblasts influence oncolytic viral therapy. Arwert et al. show that transcytosis of cancer cells into fibroblasts activates STING and IRF3 to upregulate interferon-β1, eliciting a transcriptional program to reduce the effectiveness of oncolytic viral therapy.
Borg et al. report that incorporation of the sperm-specific histone variant H3.10, which resists K27 methylation, causes H3K27me3 removal from sperm chromatin in plants, thus facilitating the expression of sperm-specific genes.
Three independent but complementary studies by the laboratories of Markus, Reck-Peterson and Yildiz identify a key role for LIS1 in modulating localization, activity and function of dynein in cells.
Martinez-Hoyer et al. identify recurrent TP53 or RUNX1 variants in patients with lenalidomide-resistant myelodysplastic syndromes that are associated with impaired RUNX1/GATA2-mediated megakaryocytic differentiation and cell death.
Hoffmann and colleagues report that the mammalian maternal-to-zygotic transition requires KDM4A-mediated removal of H3K9me3 from the broad H3K4me3 domains in oocytes.
Santoriello, Sporrij et al. show that the progesterone receptor associates with RNA helicase DDX21 during nucleotide depletion, promotes its binding on chromatin and rescues efficient transcription in melanoma cells.
Ubiquitin ligase Hrd1 is essential for endoplasmic-reticulum-associated protein degradation. Vasic et al. demonstrate that Hrd1 forms a retrotranslocation channel controlled by auto-ubiquitination and substrate binding.
Montagner et al. show that lung epithelial cells induce Sfrp2 expression and fibronectin fibril formation in disseminated breast cancer cells, thereby promoting their survival and latency in the lung.
Li et al. demonstrate the efficacy of correcting the mutated TERT promoter using a programmable base editing, highlighting its ability to induce senescence, arrest and regression in brain tumour models.
Lau et al. quantify endogenous concentrations of the chemokine Cxcl12 and its binding affinity for its cognate receptor Cxcr4 in zebrafish embryos, uncovering a negative-feedback loop governing directional cell migration in vivo.