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Fujita et al. show that endfoot regeneration of radial glia cells after division retains them in the ventricular zone in early development, independently of spindle orientation, but is lost during late neurogenesis.
Baccin, Al-Sabah, Velten et al. use single-cell and spatially resolved transcriptomics to map the cellular, molecular and spatial organization of the endosteal, sinusoidal and arteriolar bone marrow niches.
Ling and Sauka-Spengler reveal chromatin and transcriptional landscapes that regulate the early specification of vagal neural crest cells during the development of the enteric nervous system in chicken.
Mercey et al. demonstrate that without deuterosomes, multiciliated cells still develop the proper number of centrioles with normal step-wise kinetics, independent of the growing platform.
The T-box factors Eomes and Brachyury activate mesoderm and endoderm programs by establishing accessible chromatin at mesoderm and endoderm enhancers, and bind and repress enhancers of pluripotency and neuroectoderm genes.
Zhu et al. show that, in response to growth factors, TBKBP1 recruits TBK1 to promote its activation by PKCθ, thereby facilitating mTORC1 activation, tumour-mediated immunosuppression and tumourigenesis.
Chen et al. show that, after serum or lysophosphatidic acid stimulation, RhoA dissociates rhophilin and NF2/Kibra from STRIPAK to control MST1, MST2 and MAP4Ks to regulate Hippo signalling.
Cai et al. show that YAP forms liquid-like condensates in the nucleus that compartmentalize YAP’s DNA binding cofactors and transcription co-activators to induce transcription of YAP-specific proliferation genes.
Perry and Morioka et al. show that the chloride transporter SLC12A2 regulates apoptotic cell uptake by phagocytes and, together with SLC12 kinases WNK1, OSR1 and SPAK, this pathway maintains an anti-inflammatory gene signature.
Pei et al. show that rhythmic redox signalling controls CLOCK through endogenous H2O2 oscillations via reversible oxidative modifications, and that p66Shc modulates the rhythm of H2O2 levels.
Using single-cell transcriptomics and in vivo injury models, Harvey et al. identify a Tppp3+Pdgfra+ stem cell population in the tendon sheath and demonstrate the role of PDGFRα signalling in regeneration and fibrosis.
Translational reprogramming during asparagine restriction, via activated MAPK signalling and enhanced translation of activating transcription factor 4 (ATF4) mRNA in melanoma and pancreatic cancer cells, provide a survival advantage.
Yvernogeau, Gautier, Petit et al. demonstrate the existence of a haemogenic endothelium capable of de novo haematopoietic stem and progenitor cell generation in the forming bone marrow of chicken and mouse fetuses and newborns.
Abramo et al. show that during mitosis, condensin-mediated loops are lost by telophase and a transient chromosome folding intermediate is formed that lacks cohesin-generated loops.
By measuring metabolic and biosynthetic activity with cell cycle progression, Litsios et el. uncover pulses in protein production rate that do not scale with cell size but drive cell cycle entry in budding yeast.
Saçma, Pospiech and co-workers show that sinusoidal niches are uniquely preserved on ageing, that they are the predominant niche for label-retaining (LR)-HSCs in aged mice and display higher reconstitution capacity compared with non-LR HSCs.
Wang et al. identify ZNFX1 as a mitochondria-localised sensor that recognizes viral dsRNA and induces a type I interferon response, thereby restricting virus infection.
Rodrigues et al. show that exosomal CEMIP derived from brain metastatic cells elicits vascular remodelling and inflammation and supports subsequent metastatic colonization in the brain microenvironment.
Shen et al. show that PTENα/β stability is regulated through a ubiquitin-dependent mechanism mediated by USP9X and FBXW11 to modulate H3K4 trimethylation through WDR5 and promote tumour development.