Articles

  • Article |

    Zhang et al. report that the lncRNA H19 stabilizes dystrophin by competing with the ubiquitin E3 ligase TRIM63 for association with dystrophin, thereby alleviating muscular dystrophies.

    • Yaohua Zhang
    • , Yajuan Li
    • , Qingsong Hu
    • , Yutao Xi
    • , Zhen Xing
    • , Zhao Zhang
    • , Lisa Huang
    • , Jianbo Wu
    • , Ke Liang
    • , Tina K. Nguyen
    • , Sergey D. Egranov
    • , Chengcao Sun
    • , Zilong Zhao
    • , David H. Hawke
    • , Jin Li
    • , Deqiang Sun
    • , Jean J. Kim
    • , Ping Zhang
    • , Jie Cheng
    • , Abid Farida
    • , Mien-Chie Hung
    • , Leng Han
    • , Radbod Darabi
    • , Chunru Lin
    •  & Liuqing Yang
  • Article |

    García-Prat, Perdiguero, Alonso-Martín et al. show that skeletal muscle contains a subpopulation of quiescent stem cells, maintained by FoxO signalling, that is preserved into late life but declines in advanced geriatric age.

    • Laura García-Prat
    • , Eusebio Perdiguero
    • , Sonia Alonso-Martín
    • , Stefania Dell’Orso
    • , Srikanth Ravichandran
    • , Stephen R. Brooks
    • , Aster H. Juan
    • , Silvia Campanario
    • , Kan Jiang
    • , Xiaotong Hong
    • , Laura Ortet
    • , Vanessa Ruiz-Bonilla
    • , Marta Flández
    • , Victoria Moiseeva
    • , Elena Rebollo
    • , Mercè Jardí
    • , Hong-Wei Sun
    • , Antonio Musarò
    • , Marco Sandri
    • , Antonio del Sol
    • , Vittorio Sartorelli
    •  & Pura Muñoz-Cánoves
  • Article |

    Saliakoura et al. find that PLCγ1 is suppressed in hypoxic KRAS-mutant lung cancer cells, which impairs Ca2+ entry into the mitochondria and promotes glycolysis to enhance tumour progression.

    • Maria Saliakoura
    • , Matteo Rossi Sebastiano
    • , Chiara Pozzato
    • , Florian H. Heidel
    • , Tina M. Schnöder
    • , Spasenija Savic Prince
    • , Lukas Bubendorf
    • , Paolo Pinton
    • , Ralph A. Schmid
    • , Johanna Baumgartner
    • , Stefan Freigang
    • , Sabina A. Berezowska
    • , Alessandro Rimessi
    •  & Georgia Konstantinidou
  • Article |

    Ros et al. show that the ER-resident chaperone calnexin (Cnx) and its partner ERp57 are trafficked to cell surface invadosomes and induce ECM degradation, promoting tumour invasiveness.

    • Manon Ros
    • , Anh Tuan Nguyen
    • , Joanne Chia
    • , Son Le Tran
    • , Xavier Le Guezennec
    • , Ruth McDowall
    • , Sergey Vakhrushev
    • , Henrik Clausen
    • , Martin James Humphries
    • , Frederic Saltel
    •  & Frederic André Bard
  • Article |

    Aharonov et al. use in vivo genetic approaches to show that ErBB2-mediated YAP activation initiates epithelial–mesenchymal transition-like processes and dedifferentiation of cardiomyocytes to drive heart regeneration.

    • Alla Aharonov
    • , Avraham Shakked
    • , Kfir Baruch Umansky
    • , Alon Savidor
    • , Alexander Genzelinakh
    • , David Kain
    • , Daria Lendengolts
    • , Or-Yam Revach
    • , Yuka Morikawa
    • , Jixin Dong
    • , Yishai Levin
    • , Benjamin Geiger
    • , James F. Martin
    •  & Eldad Tzahor
  • Article |

    Cassandras et al. show that Gli1-expressing mesenchymal stromal cells promote metaplastic differentiation of airway progenitors into basal cells by antagonizing BMP signalling in lung fibrosis.

    • Monica Cassandras
    • , Chaoqun Wang
    • , Jaymin Kathiriya
    • , Tatsuya Tsukui
    • , Peri Matatia
    • , Michael Matthay
    • , Paul Wolters
    • , Ari Molofsky
    • , Dean Sheppard
    • , Hal Chapman
    •  & Tien Peng
  • Article |

    Gao et al. identify a piRNA, CHAPIR, that targets the m6A methylation of PARP10 and promotes the GSK3β-induced accumulation of nuclear NFATC4, thereby modulating cardiac hypertrophy and heart function upon pressure overload.

    • Xiang-Qian Gao
    • , Yu-Hui Zhang
    • , Fang Liu
    • , Murugavel Ponnusamy
    • , Xue-Mei Zhao
    • , Lu-Yu Zhou
    • , Mei Zhai
    • , Cui-Yun Liu
    • , Xin-Min Li
    • , Man Wang
    • , Chan Shan
    • , Pei-Pei Shan
    • , Yin Wang
    • , Yan-Han Dong
    • , Li-Li Qian
    • , Tao Yu
    • , Jie Ju
    • , Tao Wang
    • , Kai Wang
    • , Xin-Zhe Chen
    • , Yun-Hong Wang
    • , Jian Zhang
    • , Pei-Feng Li
    •  & Kun Wang
  • Article |

    LRRC31 links DNA repair and radiation efficacy Chen et al. perform a genome-wide CRIPSR screen and identify LRRC31, which interacts with Ku70/80 to suppress DNA repair and enhances the efficacy of radiation therapy in breast cancer brain metastasis.

    • Yanke Chen
    • , Ting Jiang
    • , Hongyi Zhang
    • , Xingchun Gou
    • , Cong Han
    • , Jianhui Wang
    • , Ann T. Chen
    • , Jun Ma
    • , Jun Liu
    • , Zeming Chen
    • , Xintao Jing
    • , Hong Lei
    • , Zhenzhen Wang
    • , Youmei Bao
    • , Mehdi Baqri
    • , Yong Zhu
    • , Ranjit S. Bindra
    • , James E. Hansen
    • , Jun Dou
    • , Chen Huang
    •  & Jiangbing Zhou
  • Article |

    Nakamura et al. find that the master transcriptional regulator of lysosomal biogenesis and autophagy TFEB is activated following LC3 lipidation during lysosomal damage and show the importance of this mechanism during kidney injury.

    • Shuhei Nakamura
    • , Saki Shigeyama
    • , Satoshi Minami
    • , Takayuki Shima
    • , Shiori Akayama
    • , Tomoki Matsuda
    • , Alessandra Esposito
    • , Gennaro Napolitano
    • , Akiko Kuma
    • , Tomoko Namba-Hamano
    • , Jun Nakamura
    • , Kenichi Yamamoto
    • , Miwa Sasai
    • , Ayaka Tokumura
    • , Mika Miyamoto
    • , Yukako Oe
    • , Toshiharu Fujita
    • , Seigo Terawaki
    • , Atsushi Takahashi
    • , Maho Hamasaki
    • , Masahiro Yamamoto
    • , Yukinori Okada
    • , Masaaki Komatsu
    • , Takeharu Nagai
    • , Yoshitsugu Takabatake
    • , Haoxing Xu
    • , Yoshitaka Isaka
    • , Andrea Ballabio
    •  & Tamotsu Yoshimori
  • Article |

    Lynch et al. demonstrate that inhibiting CDK8 and CDK19 kinases increases Mediator-driven recruitment of RNA Pol II to promoters and enhancers, therefore stabilizing the naive transcriptional program.

    • Cian J. Lynch
    • , Raquel Bernad
    • , Ana Martínez-Val
    • , Marta N. Shahbazi
    • , Sandrina Nóbrega-Pereira
    • , Isabel Calvo
    • , Carmen Blanco-Aparicio
    • , Carolina Tarantino
    • , Elena Garreta
    • , Laia Richart-Ginés
    • , Noelia Alcazar
    • , Osvaldo Graña-Castro
    • , Gonzalo Gómez-Lopez
    • , Irene Aksoy
    • , Maribel Muñoz-Martín
    • , Sonia Martinez
    • , Sagrario Ortega
    • , Susana Prieto
    • , Elisabeth Simboeck
    • , Alain Camasses
    • , Camille Stephan-Otto Attolini
    • , Agustin F. Fernandez
    • , Marta I. Sierra
    • , Mario F. Fraga
    • , Joaquin Pastor
    • , Daniel Fisher
    • , Nuria Montserrat
    • , Pierre Savatier
    • , Javier Muñoz
    • , Magdalena Zernicka-Goetz
    •  & Manuel Serrano
  • Article |

    Paris et al. show that after injury or influenza infection alveolar type II cells signal via a STAT3–BDNF axis that activates the TrkB receptor on mesenchymal niche cells and enhances alveolar repair.

    • Andrew J. Paris
    • , Katharina E. Hayer
    • , Joseph H. Oved
    • , Daphne C. Avgousti
    • , Sushila A. Toulmin
    • , Jarod A. Zepp
    • , William J. Zacharias
    • , Jeremy B. Katzen
    • , Maria C. Basil
    • , Madison M. Kremp
    • , April R. Slamowitz
    • , Sowmya Jayachandran
    • , Aravind Sivakumar
    • , Ning Dai
    • , Ping Wang
    • , David B. Frank
    • , Laurence C. Eisenlohr
    • , Edward Cantu III
    • , Michael F. Beers
    • , Matthew D. Weitzman
    • , Edward E. Morrisey
    •  & G. Scott Worthen
  • Article |

    Lauria et al. show that SMN, the loss of which causes spinal muscular atrophy (SMA), preferentially positions ribosomes within the first five codons of SMA-related mRNAs and enhances their translation.

    • Fabio Lauria
    • , Paola Bernabò
    • , Toma Tebaldi
    • , Ewout Joan Nicolaas Groen
    • , Elena Perenthaler
    • , Federica Maniscalco
    • , Annalisa Rossi
    • , Deborah Donzel
    • , Massimiliano Clamer
    • , Marta Marchioretto
    • , Neža Omersa
    • , Julia Orri
    • , Mauro Dalla Serra
    • , Gregor Anderluh
    • , Alessandro Quattrone
    • , Alberto Inga
    • , Thomas Henry Gillingwater
    •  & Gabriella Viero
  • Article |

    Hou et al. show that following hypoxia PD-L1 translocates into the nucleus to enhance transcription of GSDMC, which is then cleaved and activated by caspase-8 to cause pyroptosis in cancer cells.

    • Junwei Hou
    • , Rongce Zhao
    • , Weiya Xia
    • , Chiung-Wen Chang
    • , Yun You
    • , Jung-Mao Hsu
    • , Lei Nie
    • , Yeh Chen
    • , Yu-Chuan Wang
    • , Chunxiao Liu
    • , Wei-Jan Wang
    • , Yun Wu
    • , Baozhen Ke
    • , Jennifer L. Hsu
    • , Kebin Huang
    • , Zu Ye
    • , Yi Yang
    • , Xianghou Xia
    • , Yintao Li
    • , Chia-Wei Li
    • , Bin Shao
    • , John A. Tainer
    •  & Mien-Chie Hung
  • Article |

    Daneshvar et al. show that BRD3 and the lncRNA DIGIT form phase-separated condensates at genomic regions with H3K18ac to co-regulate the transcription of genes that drive endoderm differentiation.

    • Kaveh Daneshvar
    • , M. Behfar Ardehali
    • , Isaac A. Klein
    • , Fu-Kai Hsieh
    • , Arcadia J. Kratkiewicz
    • , Amin Mahpour
    • , Sabrina O. L. Cancelliere
    • , Chan Zhou
    • , Brett M. Cook
    • , Wenyang Li
    • , Joshua V. Pondick
    • , Sweta K. Gupta
    • , Sean P. Moran
    • , Richard A. Young
    • , Robert E. Kingston
    •  & Alan C. Mullen
  • Article |

    Here Miceli et al. show that shear stress on primary cilia induces mitochondrial biogenesis and metabolic reprogramming in kidney epithelial cells through lipophagy stimulation.

    • Caterina Miceli
    • , Federica Roccio
    • , Lucille Penalva-Mousset
    • , Martine Burtin
    • , Christine Leroy
    • , Ivan Nemazanyy
    • , Nicolas Kuperwasser
    • , Marco Pontoglio
    • , Gérard Friedlander
    • , Etienne Morel
    • , Fabiola Terzi
    • , Patrice Codogno
    •  & Nicolas Dupont
  • Article |

    Moro et al. show that hypermethylation-induced silencing of the ubiquitin ligase FBXL7 rescues c-SRC from ubiquitin-mediated degradation and enhances epithelial-to-mesenchymal transition and metastasis.

    • Loredana Moro
    • , Daniele Simoneschi
    • , Emma Kurz
    • , Arnaldo A. Arbini
    • , Shaowen Jang
    • , Nicoletta Guaragnella
    • , Sergio Giannattasio
    • , Wei Wang
    • , Yu-An Chen
    • , Geoffrey Pires
    • , Andrew Dang
    • , Elizabeth Hernandez
    • , Payal Kapur
    • , Ankita Mishra
    • , Aristotelis Tsirigos
    • , George Miller
    • , Jer-Tsong Hsieh
    •  & Michele Pagano
  • Article |

    Ilina et al. investigate the balance between cell adhesion and matrix density on patterns of collective breast cancer cell invasion using three-dimensional models of the extracellular matrix, in vivo imaging and in silico modelling

    • Olga Ilina
    • , Pavlo G. Gritsenko
    • , Simon Syga
    • , Jürgen Lippoldt
    • , Caterina A. M. La Porta
    • , Oleksandr Chepizhko
    • , Steffen Grosser
    • , Manon Vullings
    • , Gert-Jan Bakker
    • , Jörn Starruß
    • , Peter Bult
    • , Stefano Zapperi
    • , Josef A. Käs
    • , Andreas Deutsch
    •  & Peter Friedl
  • Article |

    Gao et al. uncover p300-induced acetylation and HDAC2-mediated deacetylation of PD-L1, which modulate its nuclear translocation to affect the expression of immune genes and the efficacy of anti-PD-1 therapy.

    • Yang Gao
    • , Naoe Taira Nihira
    • , Xia Bu
    • , Chen Chu
    • , Jinfang Zhang
    • , Aleksandra Kolodziejczyk
    • , Yizeng Fan
    • , Ngai Ting Chan
    • , Leina Ma
    • , Jing Liu
    • , Dong Wang
    • , Xiaoming Dai
    • , Huadong Liu
    • , Masaya Ono
    • , Akira Nakanishi
    • , Hiroyuki Inuzuka
    • , Brian J. North
    • , Yu-Han Huang
    • , Samanta Sharma
    • , Yan Geng
    • , Wei Xu
    • , X. Shirley Liu
    • , Lei Li
    • , Yoshio Miki
    • , Piotr Sicinski
    • , Gordon J. Freeman
    •  & Wenyi Wei
  • Article |

    Nowosad et al. show that during amino acid starvation, the cell-cycle inhibitor p27 binds LAMTOR1 on lysosomes to inhibit mTOR and promote autophagy, linking cell division and cell growth machineries.

    • Ada Nowosad
    • , Pauline Jeannot
    • , Caroline Callot
    • , Justine Creff
    • , Renaud Thierry Perchey
    • , Carine Joffre
    • , Patrice Codogno
    • , Stephane Manenti
    •  & Arnaud Besson
  • Article |

    Kumar et al. show that mammalian Atg8 proteins along with IRGM regulate the lysosomal system via mTOR and TFEB, respectively, in the response to pathogens.

    • Suresh Kumar
    • , Ashish Jain
    • , Seong Won Choi
    • , Gustavo Peixoto Duarte da Silva
    • , Lee Allers
    • , Michal H. Mudd
    • , Ryan Scott Peters
    • , Jan Haug Anonsen
    • , Tor-Erik Rusten
    • , Michael Lazarou
    •  & Vojo Deretic
  • Article |

    Profiling phenotype switching in melanoma. Wouters et al. perform large-scale gene expression analysis in patient samples and identify transcriptional networks that modulate the intermediate cell state and ultimate mesenchymal switching in melanoma.

    • Jasper Wouters
    • , Zeynep Kalender-Atak
    • , Liesbeth Minnoye
    • , Katina I. Spanier
    • , Maxime De Waegeneer
    • , Carmen Bravo González-Blas
    • , David Mauduit
    • , Kristofer Davie
    • , Gert Hulselmans
    • , Ahmad Najem
    • , Michael Dewaele
    • , Dennis Pedri
    • , Florian Rambow
    • , Samira Makhzami
    • , Valerie Christiaens
    • , Frederik Ceyssens
    • , Ghanem Ghanem
    • , Jean-Christophe Marine
    • , Suresh Poovathingal
    •  & Stein Aerts
  • Article |

    Dhamija et al. profile 3,412 nonstop mutations from 62 tumour entities and as proof of concept demonstrate that six such mutations cause degradation and loss of the tumour suppressor SMAD4.

    • Sonam Dhamija
    • , Chul Min Yang
    • , Jeanette Seiler
    • , Ksenia Myacheva
    • , Maiwen Caudron-Herger
    • , Angela Wieland
    • , Mahmoud Abdelkarim
    • , Yogita Sharma
    • , Marisa Riester
    • , Matthias Groß
    • , Jochen Maurer
    •  & Sven Diederichs
  • Article |

    After lung injury, Kobayashi, Tata et al. find an intermediate cell state during the transition of alveolar type-2 into type-1 cells that is associated with senescence, controlled by TP53 and persists in fibrosis.

    • Yoshihiko Kobayashi
    • , Aleksandra Tata
    • , Arvind Konkimalla
    • , Hiroaki Katsura
    • , Rebecca F. Lee
    • , Jianhong Ou
    • , Nicholas E. Banovich
    • , Jonathan A. Kropski
    •  & Purushothama Rao Tata
  • Article |

    Vietri et al. show that the micronucleus fails to restrain ESCRT-III spreading due to its small size, resulting in aberrant accumulation of ESCRT-III to drive micronuclear collapse and DNA fragmentation.

    • Marina Vietri
    • , Sebastian W. Schultz
    • , Aurélie Bellanger
    • , Carl M. Jones
    • , Louise I. Petersen
    • , Camilla Raiborg
    • , Ellen Skarpen
    • , Christeen Ramane J. Pedurupillay
    • , Ingrid Kjos
    • , Eline Kip
    • , Romy Timmer
    • , Ashish Jain
    • , Philippe Collas
    • , Roland L. Knorr
    • , Sushma N. Grellscheid
    • , Halim Kusumaatmaja
    • , Andreas Brech
    • , Francesca Micci
    • , Harald Stenmark
    •  & Coen Campsteijn
  • Article |

    Burton et al. show that H3K9me3 deposition catalysed by SUV39H2 and regulated by pericentromeric RNAs in the mouse paternal pronucleus does not suppress gene expression, but bookmarks promoters for compaction.

    • Adam Burton
    • , Vincent Brochard
    • , Carmen Galan
    • , Elias R. Ruiz-Morales
    • , Quirze Rovira
    • , Diego Rodriguez-Terrones
    • , Kai Kruse
    • , Stéphanie Le Gras
    • , Vishnu S. Udayakumar
    • , Hang Gyeong Chin
    • , André Eid
    • , Xiaoyu Liu
    • , Chenfei Wang
    • , Shaorong Gao
    • , Sriharsa Pradhan
    • , Juan M. Vaquerizas
    • , Nathalie Beaujean
    • , Thomas Jenuwein
    •  & Maria-Elena Torres-Padilla
  • Article |

    Cao et al. show that SPIN90 enhances formation of Arp2/3-mediated unbranched filaments and promotes a formin-based cortex by recruiting mDia1 or forming a ternary SPIN90–Arp2/3–mDia1 complex.

    • Luyan Cao
    • , Amina Yonis
    • , Malti Vaghela
    • , Elias H. Barriga
    • , Priyamvada Chugh
    • , Matthew B. Smith
    • , Julien Maufront
    • , Geneviève Lavoie
    • , Antoine Méant
    • , Emma Ferber
    • , Miia Bovellan
    • , Art Alberts
    • , Aurélie Bertin
    • , Roberto Mayor
    • , Ewa K. Paluch
    • , Philippe P. Roux
    • , Antoine Jégou
    • , Guillaume Romet-Lemonne
    •  & Guillaume Charras
  • Article |

    Sheikh et al. show that deficiency in the lysine acetyltransferase MOF causes aberrant accumulation of fatty acids in neural cells, which in turn triggers inflammation in nearby pericytes, resulting in brain haemorrhaging.

    • Bilal N. Sheikh
    • , Sukanya Guhathakurta
    • , Tsz Hong Tsang
    • , Marius Schwabenland
    • , Gina Renschler
    • , Benjamin Herquel
    • , Vivek Bhardwaj
    • , Herbert Holz
    • , Thomas Stehle
    • , Olga Bondareva
    • , Nadim Aizarani
    • , Omar Mossad
    • , Oliver Kretz
    • , Wilfried Reichardt
    • , Aindrila Chatterjee
    • , Laura J. Braun
    • , Julien Thevenon
    • , Herve Sartelet
    • , Thomas Blank
    • , Dominic Grün
    • , Dominik von Elverfeldt
    • , Tobias B. Huber
    • , Dietmar Vestweber
    • , Sergiy Avilov
    • , Marco Prinz
    • , Joerg M. Buescher
    •  & Asifa Akhtar
  • Article |

    Roider et al. combine scRNA-seq and transcriptome-informed flow cytometry, and uncover transcriptionally different malignant subclones with distinct drug responses and T-cell profiles in B-cell non-Hodgkin lymphoma.

    • Tobias Roider
    • , Julian Seufert
    • , Alexey Uvarovskii
    • , Felix Frauhammer
    • , Marie Bordas
    • , Nima Abedpour
    • , Marta Stolarczyk
    • , Jan-Philipp Mallm
    • , Sophie A. Herbst
    • , Peter-Martin Bruch
    • , Hyatt Balke-Want
    • , Michael Hundemer
    • , Karsten Rippe
    • , Benjamin Goeppert
    • , Martina Seiffert
    • , Benedikt Brors
    • , Gunhild Mechtersheimer
    • , Thorsten Zenz
    • , Martin Peifer
    • , Björn Chapuy
    • , Matthias Schlesner
    • , Carsten Müller-Tidow
    • , Stefan Fröhling
    • , Wolfgang Huber
    • , Simon Anders
    •  & Sascha Dietrich
  • Article |

    Bischof and colleagues report that AP-1 bookmarks prospective senescence enhancers for future activation to achieve a timely execution of the senescence programme.

    • Ricardo Iván Martínez-Zamudio
    • , Pierre-François Roux
    • , José Américo N.L.F. de Freitas
    • , Lucas Robinson
    • , Gregory Doré
    • , Bin Sun
    • , Dimitri Belenki
    • , Maja Milanovic
    • , Utz Herbig
    • , Clemens A. Schmitt
    • , Jesús Gil
    •  & Oliver Bischof
  • Article |

    Exon–intron-fused RAB22A regulates metastasis of osteosarcoma. Liao et al. show that protein products resulting from chromosomal translocations involving RAB22A mediate release of GTP-bound RhoA, induce its activation and promote lung metastasis of osteosarcoma.

    • Dan Liao
    • , Li Zhong
    • , Junqiang Yin
    • , Cuiling Zeng
    • , Xin Wang
    • , Xingchuan Huang
    • , Jinna Chen
    • , Hong Zhang
    • , Ruhua Zhang
    • , Xin-Yuan Guan
    • , Xintao Shuai
    • , Jianhua Sui
    • , Song Gao
    • , Wuguo Deng
    • , Yi-Xin Zeng
    • , Jing-Nan Shen
    • , Jian Chen
    •  & Tiebang Kang
  • Article |

    Baksh et al. show that oncogenic epidermal stem cells require extracellular serine to initiate squamous cell carcinoma via altering dioxygenases that remove H3K27me3.

    • Sanjeethan C. Baksh
    • , Pavlina K. Todorova
    • , Shiri Gur-Cohen
    • , Brian Hurwitz
    • , Yejing Ge
    • , Jesse S. S. Novak
    • , Matthew T. Tierney
    • , June dela Cruz-Racelis
    • , Elaine Fuchs
    •  & Lydia W. S. Finley
  • Article |

    Zhang et al. show that dynamin forms a helical structure with actin and, upon disruption, enhances branched actin polymerization, constituting a dynamic cycle to regulate actin cytoskeleton mechanical strength.

    • Ruihui Zhang
    • , Donghoon M. Lee
    • , John R. Jimah
    • , Nathalie Gerassimov
    • , Changsong Yang
    • , Sangjoon Kim
    • , Delgermaa Luvsanjav
    • , Jonathan Winkelman
    • , Marcel Mettlen
    • , Michael E. Abrams
    • , Raghav Kalia
    • , Peter Keene
    • , Pratima Pandey
    • , Benjamin Ravaux
    • , Ji Hoon Kim
    • , Jonathon A. Ditlev
    • , Guofeng Zhang
    • , Michael K. Rosen
    • , Adam Frost
    • , Neal M. Alto
    • , Margaret Gardel
    • , Sandra L. Schmid
    • , Tatyana M. Svitkina
    • , Jenny E. Hinshaw
    •  & Elizabeth H. Chen
  • Article |

    Boyle et al. show that ROCK upregulates PERK signalling in epithelia of breast cancer, thereby enhancing recruitment and function of cancer-associated fibroblasts through CRELD2 to promote tumourigenesis.

    • Sarah Theresa Boyle
    • , Valentina Poltavets
    • , Jasreen Kular
    • , Natasha Theresa Pyne
    • , Jarrod John Sandow
    • , Alexander Charles Lewis
    • , Kendelle Joan Murphy
    • , Natasha Kolesnikoff
    • , Paul Andre Bartholomew Moretti
    • , Melinda Nay Tea
    • , Vinay Tergaonkar
    • , Paul Timpson
    • , Stuart Maxwell Pitson
    • , Andrew Ian Webb
    • , Robert John Whitfield
    • , Angel Francisco Lopez
    • , Marina Kochetkova
    •  & Michael Susithiran Samuel
  • Article |

    Bi et al. reveal a coordinated function for GATA3 and AP1 in altering enhancer landscapes, thereby promoting a basal/mesenchymal phenotype and endocrine resistance in breast cancer.

    • Mingjun Bi
    • , Zhao Zhang
    • , Yi-Zhou Jiang
    • , Pengya Xue
    • , Hu Wang
    • , Zhao Lai
    • , Xiaoyong Fu
    • , Carmine De Angelis
    • , Yue Gong
    • , Zhen Gao
    • , Jianhua Ruan
    • , Victor X. Jin
    • , Elisabetta Marangoni
    • , Elodie Montaudon
    • , Christopher K. Glass
    • , Wei Li
    • , Tim Hui-Ming Huang
    • , Zhi-Ming Shao
    • , Rachel Schiff
    • , Lizhen Chen
    •  & Zhijie Liu
  • Article |

    Adam, Yang et al. show that the transcription factors NFIB and NFIX promote stemness by establishing chromatin accessibility and regulating the super-enhancers that govern bulge stem cell identity.

    • Rene C. Adam
    • , Hanseul Yang
    • , Yejing Ge
    • , Nicole R. Infarinato
    • , Shiri Gur-Cohen
    • , Yuxuan Miao
    • , Ping Wang
    • , Yilin Zhao
    • , Catherine P. Lu
    • , Jeong E. Kim
    • , Joo Y. Ko
    • , Seung S. Paik
    • , Richard M. Gronostajski
    • , Jaehwan Kim
    • , James G. Krueger
    • , Deyou Zheng
    •  & Elaine Fuchs
  • Article |

    Yu, Zhou, Cao, He et al. show that BMP4 reconfigures the nuclear architecture during the transition from primed to naive pluripotency by targeting Zbtb7a and Zbtb7b, which encode proteins that mediate the opening of naive chromatin loci.

    • Shengyong Yu
    • , Chunhua Zhou
    • , Shangtao Cao
    • , Jiangping He
    • , Baomei Cai
    • , Kaixin Wu
    • , Yue Qin
    • , Xingnan Huang
    • , Lizhan Xiao
    • , Jing Ye
    • , Shuyang Xu
    • , Wenxiu Xie
    • , Junqi Kuang
    • , Shilong Chu
    • , Jing Guo
    • , He Liu
    • , Wei Pang
    • , Lin Guo
    • , Mengying Zeng
    • , Xiaoshan Wang
    • , Rongping Luo
    • , Chen Li
    • , Guoqing Zhao
    • , Bo Wang
    • , Linlin Wu
    • , Jiekai Chen
    • , Jing Liu
    •  & Duanqing Pei
  • Article |

    Dong, Hao, Zhang, Zhu, Cheng et al. use single-cell RNA sequencing to characterize 28 haematopoietic cell populations and subsequently follow the fate and kinetics of HSCs upon transplantation in the mouse.

    • Fang Dong
    • , Sha Hao
    • , Sen Zhang
    • , Caiying Zhu
    • , Hui Cheng
    • , Zining Yang
    • , Fiona K. Hamey
    • , Xiaofang Wang
    • , Ai Gao
    • , Fengjiao Wang
    • , Yun Gao
    • , Ji Dong
    • , Chenchen Wang
    • , Jinyong Wang
    • , Yu Lan
    • , Bing Liu
    • , Hideo Ema
    • , Fuchou Tang
    • , Berthold Göttgens
    • , Ping Zhu
    •  & Tao Cheng
  • Article |

    Neagu, van Genderen and Escudero et al. show that simultaneous inhibition of WNT and MEK signalling maintains a naive-primed intermediate pluripotency state in vitro, which displays features of the mouse embryonic rosette.

    • Alex Neagu
    • , Emiel van Genderen
    • , Irene Escudero
    • , Lucas Verwegen
    • , Dorota Kurek
    • , Johannes Lehmann
    • , Jente Stel
    • , René A. M. Dirks
    • , Guido van Mierlo
    • , Alex Maas
    • , Cindy Eleveld
    • , Yang Ge
    • , Alexander. T. den Dekker
    • , Rutger W. W. Brouwer
    • , Wilfred F. J. van IJcken
    • , Miha Modic
    • , Micha Drukker
    • , Joop H. Jansen
    • , Nicolas C. Rivron
    • , Esther B. Baart
    • , Hendrik Marks
    •  & Derk ten Berge
  • Article |

    Huang et al. show that, in response to chemotherapy, PTEN directly interacts with NLRP3 in myeloid cells to enhance inflammasome activation and antitumour immune responses.

    • Yi Huang
    • , Huanyu Wang
    • , Yize Hao
    • , Hualong Lin
    • , Menghao Dong
    • , Jin Ye
    • , Lei Song
    • , Yunzhi Wang
    • , Qingqing Li
    • , Benjie Shan
    • , Yizhou Jiang
    • , Hongqi Li
    • , Zhiming Shao
    • , Guido Kroemer
    • , Huafeng Zhang
    • , Li Bai
    • , Tengchuan Jin
    • , Chao Wang
    • , Yuting Ma
    • , Yongping Cai
    • , Chen Ding
    • , Suling Liu
    • , Yueyin Pan
    • , Wei Jiang
    •  & Rongbin Zhou
  • Article |

    Li et al. show that hepatocyte-specific loss of Fbp1 in mice leads to steatosis and senescence in hepatic stellate cells, thereby disrupting metabolism and facilitating liver tumorigenesis.

    • Fuming Li
    • , Peiwei Huangyang
    • , Michelle Burrows
    • , Kathy Guo
    • , Romain Riscal
    • , Jason Godfrey
    • , Kyoung Eun Lee
    • , Nan Lin
    • , Pearl Lee
    • , Ian A. Blair
    • , Brian Keith
    • , Bo Li
    •  & M. Celeste Simon
  • Article |

    Dawson et al. characterize a macrophage population associated with mammary ducts that are long lived, derive from embryonic precursors and have multiple roles in pregnancy, lactation, involution and cancer.

    • Caleb A. Dawson
    • , Bhupinder Pal
    • , François Vaillant
    • , Luke C. Gandolfo
    • , Zhaoyuan Liu
    • , Camille Bleriot
    • , Florent Ginhoux
    • , Gordon K. Smyth
    • , Geoffrey J. Lindeman
    • , Scott N. Mueller
    • , Anne C. Rios
    •  & Jane E. Visvader
  • Article |

    Lis1 regulates dynein activity. Three independent but complementary studies by the laboratories of Markus, Reck-Peterson and Yildiz identify a key role for Lis1 in modulating localization, activity and function of dynein in cells.

    • Mohamed M. Elshenawy
    • , Emre Kusakci
    • , Sara Volz
    • , Janina Baumbach
    • , Simon L. Bullock
    •  & Ahmet Yildiz
  • Article |

    Targeting resistant stem cells in leukaemia, Perry et al. show that doxorubicin at low doses decreases Akt-mediated β-catenin activity, downregulates expression of multiple immune-checkpoint genes and dampens tumorigenesis of leukaemia stem cells.

    • John M. Perry
    • , Fang Tao
    • , Anuradha Roy
    • , Tara Lin
    • , Xi C. He
    • , Shiyuan Chen
    • , Xiuling Lu
    • , Jacqelyn Nemechek
    • , Linhao Ruan
    • , Xiazhen Yu
    • , Debra Dukes
    • , Andrea Moran
    • , Jennifer Pace
    • , Kealan Schroeder
    • , Meng Zhao
    • , Aparna Venkatraman
    • , Pengxu Qian
    • , Zhenrui Li
    • , Mark Hembree
    • , Ariel Paulson
    • , Zhiquan He
    • , Dong Xu
    • , Thanh-Huyen Tran
    • , Prashant Deshmukh
    • , Chi Thanh Nguyen
    • , Rajeswari M. Kasi
    • , Robin Ryan
    • , Melinda Broward
    • , Sheng Ding
    • , Erin Guest
    • , Keith August
    • , Alan S. Gamis
    • , Andrew Godwin
    • , G. Sitta Sittampalam
    • , Scott J. Weir
    •  & Linheng Li