Review Articles

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  • Yao et al. review functions of lncRNAs in controlling chromatin architecture, transcription and nuclear bodies in the nucleus and in modulating mRNA stability, translation and protein modifications in the cytoplasm.

    • Run-Wen Yao
    • Yang Wang
    • Ling-Ling Chen
    Review Article
  • Sylvain et al. review cellular functions of various RNA modifications and their roles in regulating cell fate in normal and cancer tissues.

    • Sylvain Delaunay
    • Michaela Frye
    Review Article
  • This Review describes non-redundant functions of the core transcription factors that mediate the epithelial–mesenchymal transition, and discusses the conflicting results regarding their roles in this process.

    • Marc P. Stemmler
    • Rebecca L. Eccles
    • Thomas Brabletz
    Review Article
  • Moreno-Layseca et al. discuss how integrins, key receptors that mediate cell adhesion to the extracellular matrix, are endocytosed and recycled to the cell surface to modulate cell and tissue behaviour.

    • Paulina Moreno-Layseca
    • Jaroslav Icha
    • Johanna Ivaska
    Review Article
  • In this Review Article, Chunduri and Storchová discuss how aneuploidy, often seen in cancer cells, affects gene expression, proliferation, proteotoxic stress and genomic stability, and how these changes relate to those in cancer.

    • Narendra Kumar Chunduri
    • Zuzana Storchová
    Review Article
  • Joungmok Kim and Kunliang Guan review the landmark discoveries in the mTOR field from the identification of rapamycin to the characterization of mTOR complex components, with an emphasis on the key players mediating amino acid signals to mTOR.

    • Joungmok Kim
    • Kun-Liang Guan
    Review Article
  • Lee and Schmitt discuss how the classical view of senescence as a static, terminally differentiated state has changed to that of a dynamic, reversible condition with diverse roles in tumour biology.

    • Soyoung Lee
    • Clemens A. Schmitt
    Review Article
  • In this Review, Horng and colleagues cover the emerging roles of cellular metabolism in guiding immune cell activation and cell fate decisions, and discuss how differential metabolic regulation allows for context specificity.

    • Jonathan Jung
    • Hu Zeng
    • Tiffany Horng
    Review Article
  • In this Review, Lawrence and Zoncu discuss the central role of the lysosome in cellular metabolism, including in macromolecular catabolism and nutrient recycling, and organelle crosstalk. They highlight the emerging function of the lysosome as a centre for nutrient sensing and metabolic signal transduction.

    • Rosalie E. Lawrence
    • Roberto Zoncu
    Review Article
  • In this Review, Schermelleh et al. give an overview of current super-resolution microscopy techniques and provide guidance on how best to use them to foster biological discovery.

    • Lothar Schermelleh
    • Alexia Ferrand
    • Gregor P. C. Drummen
    Review Article
  • Brunet and colleagues review emerging rejuvenation strategies that could counteract ageing features, and discuss their mechanisms of action and application against human ageing.

    • Salah Mahmoudi
    • Lucy Xu
    • Anne Brunet
    Review Article
  • In this Review, Leidal et al. discuss the role and regulation of autophagy in aging. They cover how autophagy promotes longevity and restricts cellular damage, and discuss autophagy modulators for the potential treatment of age-related diseases.

    • Andrew M. Leidal
    • Beth Levine
    • Jayanta Debnath
    Review Article
  • Goddard et al review recent advances in our understanding of dormant tumour cells, highlight their cross-talk with immune responses, and elaborate therapeutic implications to treat metastatic malignancies.

    • Erica T. Goddard
    • Ivana Bozic
    • Cyrus M. Ghajar
    Review Article
  • In this Review, Doherty and Baehrecke discuss the multiple roles of autophagy during cell survival and cell death. They cover the interplay between autophagy, apoptosis and necrosis, as well as engulfment and inflammation.

    • Johnna Doherty
    • Eric H. Baehrecke
    Review Article
  • In this Review, Tavernarakis and colleagues describe recent advances in delineating the molecular mechanisms that mediate mitophagy, and discuss the complex roles of this pathway in physiological and pathological contexts.

    • Konstantinos Palikaras
    • Eirini Lionaki
    • Nektarios Tavernarakis
    Review Article
  • Stefano Piccolo and co-authors review recent insights into how YAP and TAZ transcription factors respond to the tissue environment, and how they mediate altered cell behaviour. Feedback mechanisms and crosstalk with other pathways are discussed, as are outstanding questions in the field.

    • Antonio Totaro
    • Tito Panciera
    • Stefano Piccolo
    Review Article