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Rai et al. report that CAMSAPs can bind to minus ends of microtubules attached to γ-tubulin ring complex (γ-TuRC) and drive microtubule release. They show that CDK5RAP2, but not CLASP2, inhibits CAMSAP-mediated microtubule release from γ-TuRC.
De Jesus et al. describe the redox-mediated regulation of m6A writer methyltransferase 3, which blunts innate immune responses by modification of RNA sensor and editor component mRNAs during the onset of type 1 diabetes in β-cells.
Li, Guo, Wang and colleagues show that the ion channels TMEM63 in Drosophila and TMEM63A in mouse mediate lysosomal mechanosensitivity and modulate lysosomal morphology and function.
Dragwidge et al. report that the plant endocytic complex, the TSET–TPLATE complex, undergoes biomolecular condensation through interactions with plasma membrane phospholipids and recruits clathrin for endocytosis.
Newman et al. show that, upon mitochondrial DNA (mtDNA) replication stress, enlarged nucleoids are trafficked to endosomes. Endosomal rupture releases mtDNA into the cytoplasm, triggering cGAS–STING activation and innate immune signalling.
Yang et al. identify an essential role for ECSIT in promoting memory CD8+ T cell development by modulating fumarate synthesis and altering TCF-1 activity, thereby impacting host responses during viral infection and tumorigenesis.
Xu, Yu, Zhang, Ma, He and colleagues show that SHP-1 inhibition causes increased glycolysis and oxidative phosphorylation through PFKP in leukaemia stem cells, thereby promoting immunosurveillance and chemosensitivity in acute myeloid leukaemia.
Gross et al. show that Atg13 and Atg17 are dispensable for pexophagy during phosphate starvation in yeast. Instead, the metabolite sensor Pho81 binds the Atg1 kinase complex via Atg11 to promote Atg11 phosphorylation by Atg1 and pexophagy.
Villeneuve et al. report coordination of contractile forces during mammalian hair follicle development, with actomyosin contractility and mechanical forces from the epidermis and underlying tissue regulating placode invagination and Sox9 expression.
Son et al. show that AMPK- and PP2A-dependent p300 nucleocytoplasmic shuttling regulates mTORC1 activity in response to nutrient status. Models of Hutchinson–Gilford progeria syndrome display increased cytoplasmic p300 and mTORC1 hyperactivation.
Joyce, Pascual et al. identify luminal progenitors as likely cells-of-origin in BRCA2-mutant breast cancer, exhibiting dysregulated proteostasis and translation, which may be therapeutically targeted via mTORC1 inhibition.
Reverte-Salisa et al. show that, in preadipocytes, EPAC1 enhances brown adipose tissue growth and increases the function of thermogenic fat in obesogenic conditions. Activation of EPAC1 induces human brown adipocyte proliferation and differentiation.
Using modification-induced misincorporation tRNA sequencing, Gao and Behrens find that on differentiation, reduced mTORC1 signalling activates MAF1, which restricts RNA polymerase III to human tRNA housekeeping genes, to ensure that tRNA anticodon pools remain stable.
Bravo González-Blas et al. uncover enhancer-gene regulatory networks underlying hepatocyte identity and their zonation state by combining single-cell and spatial multiomics with massively parallel reporter assays and deep learning.
van der Weijden et al. perform genomic, proteomic and metabolic analyses and find that FOXO1-mediated fatty acid oxidation maintains mouse embryos in diapause.
Shao et al. report that FUS interacts with the transcriptional coactivator TAZ, maintaining liquid-like properties of TAZ biomolecular condensates and enhancing TAZ transcriptional activity.
Sissoko et al. show that CENP-T local concentration regulates its ability to recruit the outer kinetochore, which may restrict complete kinetochore formation to regions with higher-order inner kinetochore assemblies.
Cui, Guo, Liu et al. identify a bacterial species, Peptostreptococcusanaerobius, in the gut that produces a tryptophan metabolite and engages intracellular pathways to modulate ferroptosis-suppressor protein 1 activity, thereby suppressing ferroptosis and promoting colorectal cancer development.
Kang et al. find that vitamin B12 from gut bacteria modulates host neural function and behaviour in Caenorhabditis elegans: vitamin B12 rewires the methionine/S-adenosylmethionine cycle and choline metabolism, impacting free choline levels for neuronal acetylcholine synthesis.