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  • Mylvaganam et al. report that an apical spectrin network in endothelial cells can transmit mechanical forces in response to shear flow-induced stress, requiring hyaluronic acid and involving PIEZO1.

    • Sivakami Mylvaganam
    • Jonathan Plumb
    • Sergio Grinstein
  • Primary cilia transduce cues, including Hedgehog (Hh) signals, and possess doublet microtubules that interact with kinesin motors. The kinesin KIF7 is important for Hh signalling and binds to GLI transcription factors. Haque et al. reveal that, surprisingly, GLI proteins bind a DNA-like part of KIF7 to promote their accumulation at the ciliary tip.

    • Dhivya Kumar
    • Jeremy F. Reiter
    News & Views
  • Chen et al. report that following genotoxic stress, a nuclear PI3K binds p53 to generate a p53–phosphoinositide signalosome that recruits AKT and its activators, resulting in nuclear AKT activation and cell survival.

    • Mo Chen
    • Suyong Choi
    • Richard A. Anderson
  • Intrinsically disordered regions are a ubiquitous class of protein domains that lack a fixed 3D structure. Here, an evolutionarily conserved family of disordered CO2 sensors has been discovered, expanding the growing repertoire of disordered regions that respond to changes in the cellular environment.

    • Ryan J. Emenecker
    • Alex S. Holehouse
    News & Views
  • In Caenorhabditis elegans, RNAi-initiated gene silencing can persist for multiple generations. A study shows that this heritable silencing requires parallel contributions of both a nuclear transcriptional silencing pathway and perinuclear condensate-localized poly(UG)-tailed transcripts to produce abundant germline siRNAs in adult progeny.

    • Nicole M. Bush
    • Craig P. Hunter
    News & Views
  • After earning a PhD in Molecular Systems Biology from ETH Zurich and studying cancer metabolism as a postdoctoral fellow at MIT, Sarah-Maria Fendt started an independent research group in 2013 in a joint appointment at the Flemish Institute for Biotechnology (VIB) and the University of Leuven (KU Leuven) in Belgium.

    • Sarah-Maria Fendt
    Turning Points
  • Williams et al. report that, upon TORC1 inhibition in yeast, mRNA of the chaperone protein ADC17 is localized to cortical actin patches where its translation is enhanced upon stress.

    • Thomas David Williams
    • Roberta Cacioppo
    • Adrien Rousseau
    Article Open Access
  • Ouyang et al. show that the RNA helicase ZNFX-1 preserves heritable RNAi by maintaining a pool of small RNA-targeted transcripts in perinuclear condensates of the Caenorhabditis elegans germline, which serve as templates for small-RNA amplification in the next generation.

    • John Paul Tsu Ouyang
    • Wenyan Lucy Zhang
    • Geraldine Seydoux
    Article Open Access
  • Pride holds a special place in the hearts of lesbian, gay, bisexual, transgender, queer, intersex, asexual+ (LGBTQIA+) individuals as a time to celebrate the progress we have made, and advocate for the advances yet to come. Here, I highlight ways in which the scientific community has had a crucial role in driving this progress, and provide a personal perspective on the importance of being open and proud of my identity as a gay cell biologist.

    • Yee-Hung Mark Chan
    World View
  • Multiple methods for deriving human cortical organoids have been established in the past decade. A study now systematically compares patterning strategies and shows that combined WNT and dual SMAD inhibition is superior to dual SMAD inhibition alone in inducing robust cortical identity in 3D human pluripotent stem-cell aggregates.

    • Alexander Atamian
    • Marcella Birtele
    • Giorgia Quadrato
    News & Views
  • Human naive pluripotent stem cells are generally believed to possess an unrestricted capacity to differentiate into both embryonic and extraembryonic lineages. However, two new studies now uncover a role for the Polycomb repressive complex 2 (PRC2) as a lineage gatekeeper that shields the potency of these cells.

    • Sergi Aranda
    • Livia Condemi
    • Luciano Di Croce
    News & Views