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  • There is increasing interest in approaches that target and eliminate senescent cells. A study reports that the coatomer complex I (COPI) pathway is important for the survival of senescent cells, and suggests that targeting this pathway could hold therapeutic promise in the context of senescence-associated diseases.

    • Stella Victorelli
    • João F. Passos
    News & Views
  • Cell death is an important biological process whose experimental detection and measurement can be difficult, especially when examining many conditions in parallel. The interpretation of cell death data is complicated by the diversity of measurement techniques and lack of standardized methods in the field. Here, we offer tips to help interpret cell death experiments.

    • Scott J. Dixon
    • Michael J. Lee
  • Human embryology is flourishing thanks to an impetus provided by embryo models formed from stem cells. These scientific advances require meticulous experimental work and a refined ethical framework, but also sensible public communication. Securing public support is essential to achieve societal impact.

    • Nicolas C. Rivron
    • Alfonso Martinez-Arias
    • Kazuto Kato
  • The main barriers for intracellular receptors to sense circulating pathogen-associated molecular patterns (PAMPs) is how these PAMPs enter the cells. A study reveals that extracellular vesicles (EVs) bind lipopolysaccharide (LPS) via the lipid bilayer and mediates LPS intracellular transfer in a CD14-dependent endocytosis to activate noncanonical NLRP3 inflammasome and pyroptosis.

    • Yi Huang
    • Rongbin Zhou
    News & Views
  • Munk et al. show that exogenous NAD+, but not its precursors, induces metabolic changes in mitochondria affecting nucleotide metabolism with impacts on genomic DNA synthesis and genome integrity.

    • Sebastian Howen Nesgaard Munk
    • Joanna Maria Merchut-Maya
    • Apolinar Maya-Mendoza
    ArticleOpen Access
  • Cells use diverse mechanisms to rid themselves of dysfunctional or excess mitochondria. A study now shows that C. elegans sperm use a previously undescribed mechanism to rapidly expel single healthy mitochondria in membrane-bound structures called mitophers.

    • Diane C. Shakes
    News & Views
  • YTHDF family members are ‘readers’ of a common mRNA modification, but their effects on mRNA translation and stability have been disputed. A new study shows that YTHDF1 and YTHDF3 are post-translationally regulated through O-GlcNAcylation, unifying disparate results and pointing to environmental cues that could modulate YTHDF function.

    • Mary W. N. Burns
    • Jennifer J. Kohler
    News & Views
  • Conferences are often held at different venues and feature innovative scientific programs; however, their design rarely changes, and barriers that exclude marginalized scientists persist. We discuss why this is a problem and offer suggestions for people and organizations seeking to create more inclusive and sustainable scientific meetings.

    • Silke Blair Chalmers
    • Suzanne Madgwick
    • Felicity Mae Davis