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  • Kara McKinley is an assistant professor of stem-cell and regenerative biology at Harvard University. In addition to advancing our understanding of endometrial regeneration, she has tackled the gender bias in the academic job market by founding the ‘Leading Edge Fellows’ program. Nature Cell Biology contacted her to discuss her career and goals for our research community.

    • Melina Casadio
    Q&A
  • The Institute of Molecular and Cell Biology (IMCB) in Singapore has helped the local scientific community to grow. Nature Cell Biology spoke to Wanjin Hong (executive director at A*STAR’s IMCB) and Guillaume Thibault (associate professor affiliated with Nanyang Technological University Singapore, National University of Singapore and A*STAR’s IMCB), who have dedicated parts of their careers to the growth of cell biology research in Singapore, about the history and directions of cell biological research programs in Singapore.

    • Melina Casadio
    Q&A
  • Extramitochondrial coenzyme Q (CoQ) can function as a potent anti-ferroptosis radical trapper. However, it is largely unknown how CoQ is transported from mitochondria to the plasma membrane. A study now suggests that PARL-mediated STARD7 processing is responsible for the cellular distribution of CoQ.

    • Deguang Liang
    • Xuejun Jiang
    News & Views
  • Tight regulation of the activity of EWS–ETS fusion proteins is essential for the growth of Ewing sarcomas. Two new studies show that the transcriptional repressor ETV6 is essential for tumour growth, acting to restrain fusion-protein-mediated gene activation, and revealing the importance of tissue-specific transcription factors to oncogenesis.

    • April A. Apfelbaum
    • Elizabeth R. Lawlor
    News & Views
  • Alternative splicing of eukaryotic messenger RNA transcripts often leads to the production of several mature RNAs — including linear RNAs and circular RNAs (circRNAs) — from a single gene locus. The names given to circRNAs are often ambiguous and lack consistency across studies. This Comment calls on the community to embrace a common nomenclature for naming circRNAs to ensure clarity and reproducibility.

    • Ling-Ling Chen
    • Albrecht Bindereif
    • Fangqing Zhao
    Comment
  • End-binding proteins attach to the dynamic plus-ends of microtubules in order to regulate microtubule polymerization and the transport of other plus-end tracking proteins (+TIPs). Three new studies dissect the multivalent interactions that constitute distinct +TIP networks and reveal that they give rise to liquid-like biomolecular condensates.

    • Bernardo Gouveia
    • Sabine Petry
    News & Views
  • The bone marrow is the daily production site for hundreds of billions of blood cells. A new study adds evidence that, during ageing, signals emanating from bone-marrow stromal cells shift to produce inflammatory factors that skew blood-cell output, driving age-related tissue deterioration.

    • Thomas H. Ambrosi
    • Charles K. F. Chan
    News & Views
  • Tumour-initiating cells are resistant to challenging growth conditions during the initiation of pancreatic cancer, but how transformed cells acquire a stress-resistant, tumour-initiating state remains unclear. Here, the authors identify a signalling cascade in which LPAR4 induces fibronectin production, cancer stemness and a tumour-initiating niche.

    • Frank Arnold
    • Mara H. Sherman
    News & Views