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  • Intrinsically disordered regions are a ubiquitous class of protein domains that lack a fixed 3D structure. Here, an evolutionarily conserved family of disordered CO2 sensors has been discovered, expanding the growing repertoire of disordered regions that respond to changes in the cellular environment.

    • Ryan J. Emenecker
    • Alex S. Holehouse
    News & Views
  • In Caenorhabditis elegans, RNAi-initiated gene silencing can persist for multiple generations. A study shows that this heritable silencing requires parallel contributions of both a nuclear transcriptional silencing pathway and perinuclear condensate-localized poly(UG)-tailed transcripts to produce abundant germline siRNAs in adult progeny.

    • Nicole M. Bush
    • Craig P. Hunter
    News & Views
  • After earning a PhD in Molecular Systems Biology from ETH Zurich and studying cancer metabolism as a postdoctoral fellow at MIT, Sarah-Maria Fendt started an independent research group in 2013 in a joint appointment at the Flemish Institute for Biotechnology (VIB) and the University of Leuven (KU Leuven) in Belgium.

    • Sarah-Maria Fendt
    Turning Points
  • Williams et al. report that, upon TORC1 inhibition in yeast, mRNA of the chaperone protein ADC17 is localized to cortical actin patches where its translation is enhanced upon stress.

    • Thomas David Williams
    • Roberta Cacioppo
    • Adrien Rousseau
    Article Open Access
  • Ouyang et al. show that the RNA helicase ZNFX-1 preserves heritable RNAi by maintaining a pool of small RNA-targeted transcripts in perinuclear condensates of the Caenorhabditis elegans germline, which serve as templates for small-RNA amplification in the next generation.

    • John Paul Tsu Ouyang
    • Wenyan Lucy Zhang
    • Geraldine Seydoux
    Article Open Access
  • Pride holds a special place in the hearts of lesbian, gay, bisexual, transgender, queer, intersex, asexual+ (LGBTQIA+) individuals as a time to celebrate the progress we have made, and advocate for the advances yet to come. Here, I highlight ways in which the scientific community has had a crucial role in driving this progress, and provide a personal perspective on the importance of being open and proud of my identity as a gay cell biologist.

    • Yee-Hung Mark Chan
    World View
  • Multiple methods for deriving human cortical organoids have been established in the past decade. A study now systematically compares patterning strategies and shows that combined WNT and dual SMAD inhibition is superior to dual SMAD inhibition alone in inducing robust cortical identity in 3D human pluripotent stem-cell aggregates.

    • Alexander Atamian
    • Marcella Birtele
    • Giorgia Quadrato
    News & Views
  • Human naive pluripotent stem cells are generally believed to possess an unrestricted capacity to differentiate into both embryonic and extraembryonic lineages. However, two new studies now uncover a role for the Polycomb repressive complex 2 (PRC2) as a lineage gatekeeper that shields the potency of these cells.

    • Sergi Aranda
    • Livia Condemi
    • Luciano Di Croce
    News & Views
  • Le et al. review various technologies for imaging RNAs in fixed and live cells and the biological insights gained from these technologies.

    • Phuong Le
    • Noorsher Ahmed
    • Gene W. Yeo
    Review Article
  • The lysosome is an essential organelle that degrades extra- and intra-cellular components and acts as a signaling hub. A study in Caenorhabditis elegans now shows that the lysosome mediates inter-tissue communication from periphery to neurons to regulate lifespan via fatty acid breakdown and secretion.

    • Jason Wayne Miklas
    • Anne Brunet
    News & Views