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  • Nature Cell Biology is proud to support fundamental cell biological studies. We look forward to continuing to publish impactful research that advances our understanding of cells in basic and applied contexts.

    Editorial
  • Efstathiou et al. describe an Argonaute-dependent endoplasmic reticulum (ER)-associated RNA silencing pathway that acts together with ER-associated protein degradation to preserve ER homeostasis and function.

    • Sotirios Efstathiou
    • Franziska Ottens
    • Thorsten Hoppe
    Article Open Access
  • Zhang et al. have data suggesting that, in the chicken embryo, monocytes foster a pro-angiogenic microenvironment in advance of angiogenesis by depositing migrasomes enriched in angiogenic factors.

    • Cuifang Zhang
    • Tianqi Li
    • Li Yu
    Article
  • The onset of differentiation has been assumed to follow withdrawal from the cell cycle. A new study shows that keratinocytes initiate differentiation before exiting the cell cycle, allowing the skin to respond rapidly to damage.

    • Albert Herms
    • Philip H. Jones
    News & Views
  • Several new technologies have used synthetic RNAs that leverage the cell’s RNA splicing machinery to drive the expression of gene products. A new study now reports a technique to dynamically and non-invasively monitor gene expression by embedding reporters within introns contained in the parent gene.

    • Salima Benbarche
    • Omar Abdel-Wahab
    News & Views
  • FG-nucleoporins of the nuclear pore complexes form a permeability barrier between the nucleus and the cytosol. FG-nucleoporins contain disordered regions and are prone to aggregation. Two studies identify the chaperone DNAJB6 as a key factor that prevents aggregation of FG-nucleoporins and assists in the biogenesis of nuclear pore complexes.

    • Janine Kirstein
    News & Views
  • PTEN, a tumour suppressor, also regulates T cell activation. A new study reports that PTEN acts as a cell-intrinsic rheostat linking TCR- and IL-23-mediated signalling to regulate development of type-17 innate-like T cells in the thymus. This work may have important implications for treating autoimmune and inflammatory diseases.

    • Nikolaos Patsoukis
    • Vassiliki A. Boussiotis
    News & Views
  • Publicly shared metabolomics data may contain key answers to central questions in cell biology, but re-use of the data is complicated by the lack of standardized experimental and computational methods in the field. This Comment provides some tips to help ensure that shared metabolomics data are re-used appropriately.

    • Ethan Stancliffe
    • Gary J. Patti
    Comment
  • In tumours, cancer cells can overcome energy stress via differential regulation of non-canonical ‘moonlighting’ functions of metabolic enzymes. A study now shows that the metabolic phosphatase fructose-1,6-bisphosphatase 1 (FBP1) can act as a nuclear protein phosphatase and reveals how this process is inhibited in cancer cells.

    • Scott A. Gerber
    • Arminja N. Kettenbach
    News & Views
  • For the past 40 years, minimal reconstituted systems have helped cell biologists to understand the mechanisms that underlie membrane traffic. Having progressed from minimal synthetic and cell-derived ensembles to direct comparison with living systems, reconstitution is poised for ever more precise and informative understanding of membrane biology.

    • Jeanne C. Stachowiak
    • Tomas Kirchhausen
    Comment